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4 papers 100 to 500 followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
Louise E Glover, Brittelle E Bowers, Bejan Saeedi, Stefan F Ehrentraut, Eric L Campbell, Amanda J Bayless, Evgenia Dobrinskikh, Agnieszka A Kendrick, Caleb J Kelly, Adrianne Burgess, Lauren Miller, Douglas J Kominsky, Paul Jedlicka, Sean P Colgan
Mucosal surfaces of the lower gastrointestinal tract are subject to frequent, pronounced fluctuations in oxygen tension, particularly during inflammation. Adaptive responses to hypoxia are orchestrated largely by the hypoxia-inducible transcription factors (HIFs). As HIF-1α and HIF-2α are coexpressed in mucosal epithelia that constitute the barrier between the lumen and the underlying immune milieu, we sought to define the discrete contribution of HIF-1 and HIF-2 transactivation pathways to intestinal epithelial cell homeostasis...
December 3, 2013: Proceedings of the National Academy of Sciences of the United States of America
Jia Liu, Lu-ning Wang
BACKGROUND: Neurodegenerative movement disorders mainly include Parkinson's disease (PD), atypical parkinsonisms, Huntington's disease (HD), and Friedreich's ataxia (FA). With mitochondrial dysfunction observed in these diseases, mitochondrial enhancement such as creatine, coenzyme Q10 (CoQ10) and its analogues (idebenone and mitoquinone) has been regarded as a potential treatment. AIM: In this paper, we systematically analysed and summarized the efficacy of mitochondrial enhancement in improving motor and other symptoms in neurodegenerative movement disorders...
January 2014: CNS Drugs
In Kyoon Lyoo, Sujung Yoon, Tae-Suk Kim, Jaeuk Hwang, Jieun E Kim, Wangyoun Won, Sujin Bae, Perry F Renshaw
OBJECTIVE: Antidepressants targeting monoaminergic neurotransmitter systems, despite their immediate effects at the synaptic level, usually require several weeks of administration to achieve clinical efficacy. The authors propose a strategy of adding creatine monohydrate (creatine) to a selective serotonin reuptake inhibitor (SSRI) in the treatment of patients with major depressive disorder. Such augmentation may lead to a more rapid onset of antidepressant effects and a greater treatment response, potentially by restoring brain bioenergetics at the cellular level...
September 2012: American Journal of Psychiatry
Patricia J Allen
Athletes, body builders, and military personnel use dietary creatine as an ergogenic aid to boost physical performance in sports involving short bursts of high-intensity muscle activity. Lesser known is the essential role creatine, a natural regulator of energy homeostasis, plays in brain function and development. Creatine supplementation has shown promise as a safe, effective, and tolerable adjunct to medication for the treatment of brain-related disorders linked with dysfunctional energy metabolism, such as Huntington's Disease and Parkinson's Disease...
May 2012: Neuroscience and Biobehavioral Reviews
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