Alyssa H Silver, Nora Esteban-Cruciani, Gabriella Azzarone, Lindsey C Douglas, Diana S Lee, Sheila Liewehr, Joanne M Nazif, Ilir Agalliu, Susan Villegas, Hai Jung H Rhim, Michael L Rinke, Katherine O'Connor
BACKGROUND AND OBJECTIVES: Bronchiolitis, the most common reason for hospitalization in children younger than 1 year in the United States, has no proven therapies effective beyond supportive care. We aimed to investigate the effect of nebulized 3% hypertonic saline (HS) compared with nebulized normal saline (NS) on length of stay (LOS) in infants hospitalized with bronchiolitis. METHODS: We conducted a prospective, randomized, double-blind, controlled trial in an urban tertiary care children's hospital in 227 infants younger than 12 months old admitted with a diagnosis of bronchiolitis (190 completed the study); 113 infants were randomized to HS (93 completed the study), and 114 to NS (97 completed the study)...
December 2015: Pediatrics