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By Kathryn Freyfogle Nephrologist
John Knight, Muh Geot Wong, Vlado Perkovic
PURPOSE OF REVIEW: Because advanced chronic kidney disease (CKD) is often an exclusion criterion for large randomized trials of the management of hypertension, clinical decision making for these patients has relied on a few small, specific studies and much extrapolation. Several blood pressure treatment guidelines have recently been reissued. This review explores the applicability of the revised recommendations to CKD. RECENT FINDINGS: Many new publications are meta-analyses, guidelines and debates about guidelines...
November 2014: Current Opinion in Nephrology and Hypertension
Donald G Klepser, Dean S Collier, Gary L Cochran
BACKGROUND: Proton pump inhibitors (PPI) are a widely-used class of drugs for the treatment of gastro-esophageal reflux disease and other acid-related disorders of the gastrointestinal tract. As a class, PPIs have demonstrated a favorable safety profile. However, case reports have suggested that this class of drugs may be linked to acute kidney injury, which may in turn lead to chronic injury or failure. The objective of this study was to determine if an association between PPIs and kidney failure exists and to estimate an effect size for the relationship between PPI use and renal disease...
July 16, 2013: BMC Nephrology
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