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dentin bonding

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By Zhongjie Li A learning dentist and dental scientist, who collect, select and dialect up-to-date evidences and research conclusions
B M Priyadarshini, S T Selvan, T B Lu, H Xie, J Neo, A S Fawzy
In this study, we are introducing a new drug-delivery approach to demineralized dentin substrates through microsized dentinal tubules in the form of drug-loaded nanocapsules. Chlorhexidine (CHX) is widely used in adhesive dentistry due to its nonspecific matrix metalloproteinase inhibitory effect and antibacterial activities. Poly(ε-caprolactone) nanocapsules (nano-PCL) loaded with CHX were fabricated by interfacial polymer deposition at PCL/CHX ratios of 125:10, 125:25, and 125:50. Unloaded nanocapsules (blank) were fabricated as control...
August 2016: Journal of Dental Research
Jianfeng Zhou, Ayaka Chiba, Debora L S Scheffel, Josimeri Hebling, Kelli Agee, Junji Tagami, Jianquo Tan, Dalia Abuelenain, Manar Abu Nawareg, Ali H Hassan, Lorenzo Breschi, Franklin R Tay, David H Pashley
OBJECTIVE: To determine if acid-etched, cross-linked dentin can be dehydrated without lowering bond strength below that of cross-linked wet-bonded dentin in vitro. METHODS: Using extracted human third molars, control acid-etched dentin was bonded with Single Bond Plus, using either the wet- or dry-bonding technique. Experimental acid-etched dentin was treated with 5mass% grape seed extract (GSE) in different solvents for 1min before undergoing wet vs dry resin-dentin bonding with Single Bond Plus...
September 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Neslihan Tekçe, Safa Tuncer, Mustafa Demirci, Sibel Balci
The aim of this study was to evaluate the effects of matrix metalloproteinases (MMPs) inhibitors on the microtensile bond strength (μTBS) and the adhesive-dentin interface of two universal dentin bonding agents, Single Bond Universal and All Bond Universal, after 12 months of water storage. Seventy extracted, caries-free, human third molars were used in this study. Of these, 50 were used for μTBS testing and 20 were used for scanning electron microscopy. The two bonding agents were applied to flat dentin surfaces in five different ways: self-etch mode, etch-and-rinse mode with 37% phosphoric acid, etch-and-rinse mode with phosphoric acid containing 1% benzalkonium chloride, etch-and-rinse mode with phosphoric acid and 2% chlorhexidine, and etch-and-rinse mode with 0...
November 2016: Scanning
Anders Hedenbjörk Lager
Dental caries is a common disease all over the world, despite the fact that it can be both effectively prevented and treated. It is driven by acids produced by oral microorganisms as a consequence of their metabolism of dietary carbohydrates. Given enough acid challenge, eventually the tooth enamel barrier will be broken down, and the carious lesion will extend into underlying hard tissue, forming a macroscopic cavity in the dentine. In comparison to biofilm on enamel, a dentine carious lesion provides a vastly different environment for the residing microorganisms...
2014: Swedish Dental Journal. Supplement
Eduardo Mahn, Valentin Rousson, Siegward Heintze
PURPOSE: To meta-analyze the literature on the clinical performance of Class V restorations to assess the factors that influence retention, marginal integrity, and marginal discoloration of cervical lesions restored with composite resins, glass-ionomer-cement-based materials [glass-ionomer cement (GIC) and resin-modified glass ionomers (RMGICs)], and polyacid-modified resin composites (PMRC). MATERIALS AND METHODS: The English literature was searched (MEDLINE and SCOPUS) for prospective clinical trials on cervical restorations with an observation period of at least 18 months...
August 2015: Journal of Adhesive Dentistry
Masaya Suzuki, Yoshihisa Taira, Chikage Kato, Koichi Shinkai, Yoshiroh Katoh
OBJECTIVES: This study examines the wound healing process in exposed rat pulp when capped with experimental adhesive resin systems. METHODS: Experimental adhesive resin system for direct pulp capping was composed of primer-I (PI), -II (PII), and -III (PIII) and an experimental bonding agent (EBA). PI was Clearfil(®) SE Bond(®)/Primer (CSP) containing 5.0 wt% CaCl2, PII was PI containing 10 wt% nanofiller (Aerosil(®) 380), and PIII was CSP containing 5.0 wt% of compounds of equal moles of synthetic peptides (pA and pB) derived from dentin matrix protein 1...
January 2016: Journal of Dentistry
Gregg P Kotchey, Yong Zhao, Valerian E Kagan, Alexander Star
As a result of their unique electronic, optical, and mechanical properties, carbon nanotubes (CNTs) have been implemented in therapeutic and imaging applications. In an idealized situation, CNTs would be disposed of after they transport their theranostic payloads. Biodegradation represents an attractive pathway for the elimination of CNT carriers post-delivery and may be integral in catalyzing the release of the cargo from the delivery vehicle. Accordingly, recent research efforts have focused on peroxidase-driven biodegradation of CNTs...
December 2013: Advanced Drug Delivery Reviews
Paulo Antônio Martins-Júnior, Marcos Augusto Sá, Alesandra Corte Reis, Celso Martins Queiroz-Junior, Marcelo Vidigal Caliari, Mauro Martins Teixeira, Luiz Orlando Ladeira, Vanessa Pinho, Anderson José Ferreira
OBJECTIVES: The objectives of this study were to assess the effects of hyaluronic acid (HY), multi-walled carbon nanotubes (MWCNT), and MWCNT functionalized with HY (HY-MWCNT) on the resolution of neutrophilic inflammation in the pleural cavity of LPS-challenged mice and to assess the influence of these materials in the inflammatory process of bone repair of tooth sockets of rats. MATERIALS AND METHODS: C57Bl/6 mice were intra-pleurally injected with HY, MWCNT, HY-MWCNT, phosphate-buffered saline (PBS), or LPS...
September 2016: Clinical Oral Investigations
N Takahashi
Recent advances in molecular biology have facilitated analyses of the oral microbiome ("Who are they?"); however, its functions (e.g., metabolic activities) are poorly understood ("What are they doing?"). This review aims to summarize our current understanding of the metabolism of the oral microbiome. Saccharolytic bacteria-including Streptococcus, Actinomyces, and Lactobacillus species-degrade carbohydrates into organic acids via the Embden-Meyerhof-Parnas pathway and several of its branch pathways, resulting in dental caries, while alkalization and acid neutralization via the arginine deiminase system, urease, and so on, counteract acidification...
December 2015: Journal of Dental Research
Asbjørn Jokstad
OBJECTIVES: To critically appraise experimental ex vivo research that has focused on secondary caries, and to offer possible explanations for the seemingly poor correlation to clinical observations. METHODS: The literature relating to the etiopathogenesis or prevention of secondary caries gained from experimental ex vivo research was reviewed, with particular emphasis on microleakage and artificial caries-like lesions. RESULTS: It is doubtful whether a caries wall lesion can exist independently of an outer enamel caries lesion...
January 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Tirthankar Mohanty, Jonathan Sjögren, Fredrik Kahn, Anas H A Abu-Humaidan, Niels Fisker, Kristian Assing, Matthias Mörgelin, Anders A Bengtsson, Niels Borregaard, Ole E Sørensen
Neutrophils are essential for host defense at the oral mucosa and neutropenia or functional neutrophil defects lead to disordered oral homeostasis. We found that neutrophils from the oral mucosa harvested from morning saliva had released neutrophil extracellular traps (undergone NETosis) in vivo. The NETosis was mediated through intracellular signals elicited by binding of sialyl Lewis(X) present on salival mucins to l-selectin on neutrophils. This led to rapid loss of nuclear membrane and intracellular release of granule proteins with subsequent neutrophil extracellular trap (NET) release independent of elastase and reduced NAD phosphate-oxidase activation...
October 29, 2015: Blood
Ning Zhang, Mary A S Melo, Chen Chen, Jason Liu, Michael D Weir, Yuxing Bai, Hockin H K Xu
OBJECTIVES: The objectives of this study were to: (1) develop a novel adhesive for prevention of tooth root caries and secondary caries by possessing a combination of protein-repellent, antibacterial, and remineralization capabilities for the first time; and (2) investigate the effects of 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM), and nanoparticles of amorphous calcium phosphate (NACP) on dentin bond strength, protein-repellent properties, and dental plaque microcosm biofilm response...
September 2015: Dental Materials: Official Publication of the Academy of Dental Materials
Alessandra Reis, Alessandro Dourado Loguercio, Marcos Schroeder, Issis Luque-Martinez, Danielle Masterson, Lucianne Cople Maia
OBJECTIVES: A systematic review and meta-analysis were performed on the risk and intensity of postoperative sensitivity (POS) in posterior resin composite restorations bonded with self-etch (SE) and etch-and-rinse (ER) adhesives. SOURCE: A comprehensive search was performed in the MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO and Cochrane Library and SIGLE without restrictions. The abstracts of the annual conference of the IADR (1990-2014), unpublished and ongoing trials registry were also searched...
September 2015: Dental Materials: Official Publication of the Academy of Dental Materials
Álfheiður Ástvaldsdóttir, Jessica Dagerhamn, Jan W V van Dijken, Aron Naimi-Akbar, Gunilla Sandborgh-Englund, Sofia Tranæus, Mikael Nilsson
OBJECTIVE: To conduct a systematic review of the literature on the longevity of posterior resin composite restorations in adults. MATERIAL AND METHODS: A systematic literature search was conducted according to pre-determined criteria for inclusion and exclusion. The studies selected were prospective clinical trials with a minimum follow-up time of 4 years, 40 restorations per experimental group and an annual attrition rate of less than 5%. Initially, abstracts and full-text articles were assessed independently and the assessment was subsequently agreed on by five reviewers...
August 2015: Journal of Dentistry
F Song, H Koo, D Ren
Adhesion of microbes, such as bacteria and fungi, to surfaces and the subsequent formation of biofilms cause multidrug-tolerant infections in humans and fouling of medical devices. To address these challenges, it is important to understand how material properties affect microbe-surface interactions and engineer better nonfouling materials. Here we review the recent progresses in this field and discuss the main challenges and opportunities. In particular, we focus on bacterial biofilms and review the effects of surface energy, charge, topography, and stiffness of substratum material on bacterial adhesion...
August 2015: Journal of Dental Research
Ahmed Almahdy, Garrit Koller, Frederic Festy, Jörg W Bartsch, Timothy F Watson, Avijit Banerjee
OBJECTIVES: To evaluate the effect of adding a matrix metalloproteinase (MMP) inhibitor (BB94, Batimastat) to the primer of a three-step etch and rinse adhesive system on caries-affected dentin (CaD) MMP activity, and to assess the effect of such an inclusion on the chemical content of the CaD-adhesive interface. METHODS: Caries-infected dentin (CiD) was excavated selectively from freshly extracted human carious teeth using a chemo-mechanical agent. Each tooth was sectioned into three slabs through the CaD retained cavity...
May 2015: Dental Materials: Official Publication of the Academy of Dental Materials
Camila Sabatini, David H Pashley
PURPOSE: This systematic review provides an overview of the different mechanisms proposed to regulate the degradation of dentin matrices by host-derived dentin proteases, particularly as it relates to their role in dental adhesion. Significant developments have taken place over the last few years that have contributed to a better understanding of all the factors affecting the durability of adhesive resin restorations. The complexity of dentin-resin interfaces mandates a thorough understanding of all the mechanical, physical and biochemical aspects that play a role in the formation of hybrid layers...
August 2014: American Journal of Dentistry
Wellington Luiz de Oliveira da Rosa, Evandro Piva, Adriana Fernandes da Silva
OBJECTIVES: A systematic review was conducted to determine whether the etch-and-rinse or self-etching mode is the best protocol for dentin and enamel adhesion by universal adhesives. DATA: This report followed the PRISMA Statement. A total of 10 articles were included in the meta-analysis. SOURCES: Two reviewers performed a literature search up to October 2014 in eight databases: PubMed, Web of Science, Scopus, BBO, SciELO, LILACS, IBECS and The Cochrane Library...
July 2015: Journal of Dentistry
D Khvostenko, S Salehi, S E Naleway, T J Hilton, J L Ferracane, J C Mitchell, J J Kruzic
OBJECTIVES: Secondary caries is the most common reason for composite restoration replacement and usually forms between dentin and the filling. The objective of this study was to investigate the combined effect of cyclic loading and bacterial exposure on bacterial penetration into gaps at the interface between dentin and resin composite restorative material using a novel bioreactor system and test specimen design. METHODS: Human molars were machined into 3mm thick disks with 2mm deep × 5 mm diameter cavity preparations into which composite restorations were placed...
June 2015: Dental Materials: Official Publication of the Academy of Dental Materials
Thiago Henrique Scarabello Stape, Leo Tjäderhane, Marcelo Rocha Marques, Flávio Henrique Baggio Aguiar, Luís Roberto Marcondes Martins
OBJECTIVES: This study examined the effect of a dimethyl sulfoxide (DMSO) wet bonding technique on the resin infiltration depths at the bonded interface and dentin bond strength of different adhesive systems. METHODS: Flat dentin surfaces of 48 human third molars were treated with 50% DMSO (experimental groups) or with distilled water (controls) before bonding using an etch-and-rinse (SBMP: Scotchbond Multi-Purpose, 3M ESPE) or a self-etch (Clearfil: Clearfil SE Bond, Kuraray) adhesive system...
June 2015: Dental Materials: Official Publication of the Academy of Dental Materials
2015-04-27 18:29:54
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