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By Paul Foster MD
Gary W Small, Prabha Siddarth, Zhaoping Li, Karen J Miller, Linda Ercoli, Natacha D Emerson, Jacqueline Martinez, Koon-Pong Wong, Jie Liu, David A Merrill, Stephen T Chen, Susanne M Henning, Nagichettiar Satyamurthy, Sung-Cheng Huang, David Heber, Jorge R Barrio
OBJECTIVE: Because curcumin's anti-inflammatory properties may protect the brain from neurodegeneration, we studied its effect on memory in non-demented adults and explored its impact on brain amyloid and tau accumulation using 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile positron emission tomography (FDDNP-PET). METHODS: Forty subjects (age 51-84 years) were randomized to a bioavailable form of curcumin (Theracurmin® containing 90 mg of curcumin twice daily [N = 21]) or placebo (N = 19) for 18 months...
March 2018: American Journal of Geriatric Psychiatry
Yogheswaran Gopalan, Ibrahim Lutfi Shuaib, Enrico Magosso, Mukhtar Alam Ansari, Mohd Rizal Abu Bakar, Jia Woei Wong, Nurzalina Abdul Karim Khan, Wei Chuen Liong, Kalyana Sundram, Bee Hong Ng, Chinna Karuthan, Kah Hay Yuen
BACKGROUND AND PURPOSE: Previous cell-based and animal studies showed mixed tocotrienols are neuroprotective, but the effect is yet to be proven in humans. Thus, the present study aimed to evaluate the protective activity of mixed tocotrienols in humans with white matter lesions (WMLs). WMLs are regarded as manifestations of cerebral small vessel disease, reflecting varying degrees of neurodegeneration and tissue damage with potential as a surrogate end point in clinical trials. METHODS: A total of 121 volunteers aged ≥35 years with cardiovascular risk factors and MRI-confirmed WMLs were randomized to receive 200 mg mixed tocotrienols or placebo twice a day for 2 years...
May 2014: Stroke; a Journal of Cerebral Circulation
Susan E Power, Eibhlís M O'Connor, R Paul Ross, Catherine Stanton, Paul W O'Toole, Gerald F Fitzgerald, Ian B Jeffery
PURPOSE: Ageing is associated with loss of cognitive function and an increased risk of dementia which is expected to place growing demands on health and long-term care providers. Among multiple causative factors, evidence suggests that cognitive impairment in older subjects may be influenced by diet. The objective of this study was to examine the association between dietary patterns, dietary glycaemic load (GL) and cognition in older Irish adults. METHODS: Community-dwelling subjects (n 208; 94 males and 114 females; aged 64-93 years) were analysed...
June 2015: European Journal of Nutrition
Martha Clare Morris, Christine C Tangney
This is a qualitative review of the evidence linking dietary fat composition to the risk of developing dementia. The review considers laboratory and animal studies that identify underlying mechanisms as well as prospective epidemiologic studies linking biochemical or dietary fatty acids to cognitive decline or incident dementia. Several lines of evidence provide support for the hypothesis that high saturated or trans fatty acids increase the risk of dementia and high polyunsaturated or monounsaturated fatty acids decrease risk...
September 2014: Neurobiology of Aging
Christy C Tangney, Hong Li, Yamin Wang, Lisa Barnes, Julie A Schneider, David A Bennett, Martha C Morris
OBJECTIVES: We examined whether accordance to the DASH (Dietary Approach to Stop Hypertension) and Mediterranean diets is associated with slower cognitive decline in a prospective Chicago cohort study of older persons, the Memory and Aging Project. METHODS: The sample comprised 826 Memory and Aging Project participants (aged 81.5 ± 7.1 years) who completed a 144-item food frequency questionnaire at baseline and 2 or more cognitive assessments over 4.1 years. Dietary scores were computed for accordance to the DASH diet (0-10) and the Mediterranean diet (MedDietScore) (0-55)...
October 14, 2014: Neurology
Melanie-Jayne R Howes, Monique S J Simmonds
PURPOSE OF REVIEW: Intake of dietary phytochemicals has frequently been associated with health benefits. Noninfectious diseases including cardiovascular disease (CVD), cancer and diabetes are major causes of death, whereas dementia cases are also increasing to 'epidemic' proportion. This review will focus on recent progress on mechanisms underlying the potential role of dietary phytochemicals in CVD, diabetes, cancer and dementia, with consideration of the latest clinical data. RECENT FINDINGS: The association of tea (Camellia sinensis), particularly catechins, with reported mechanistic effects for CVD, diabetes, cancer and cognition contributes to our understanding of the suggested benefits of tea consumption on health from limited and inconclusive clinical trial and epidemiological data...
November 2014: Current Opinion in Clinical Nutrition and Metabolic Care
Bo Qin, Brenda L Plassman, Lloyd J Edwards, Barry M Popkin, Linda S Adair, Michelle A Mendez
Modifiable lifestyle changes, including dietary changes, could translate into a great reduction in the global burden of cognitive impairment and dementia. Few studies evaluated the benefits of fish intake for delaying cognitive decline, and no studies were conducted in a Chinese population, which may differ with respect to types, amounts, and correlates of fish consumption compared with Western populations. We hypothesized that higher consumption of fish would predict slower decline in cognitive function, independent of a wide range of potential confounders...
October 2014: Journal of Nutrition
John E Lewis, H Reginald McDaniel, Marc E Agronin, David A Loewenstein, Jorge Riveros, Rafael Mestre, Mairelys Martinez, Niurka Colina, Dahlia Abreu, Janet Konefal, Judi M Woolger, Karriem H Ali
Alzheimer's disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minimal amelioration of disease symptoms and/or restoration of lost cognitive functioning. The effect of improved nutrition, particularly with dietary supplements, on cognitive functioning may offer an alternative strategy compared to standard treatment...
2013: Journal of Alzheimer's Disease: JAD
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