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Pss Germinal center

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By Xiujuan Hou rheumatology
Gabriela Hernández-Molina, Gilberto Vargas-Alarcón, Jose M Rodríguez-Pérez, Nancy Martínez-Rodríguez, Guadalupe Lima, Jorge Sánchez-Guerrero
To compare the distribution of HLA-A, B, DRB1 and DQB1 alleles among Mexican patients with primary Sjögren Syndrome (pSS), secondary SS (sSS), connective tissue disease (CTD) without (w/o) SS and historical ethnically healthy controls. We included 28 pSS, 30 sSS, 96 CTD w/o SS patients and 234 controls. HLA-A, B, DRB1 and DQB1 were amplified and sequenced using the Allele SEQR Sequenced Based Typing Kits and analyzed on the ABI Prism*3130 DNA Analyzer using the Assign software. Gene frequencies were obtained by direct counting...
April 2015: Rheumatology International
Svein Joar Johnsen, Ellen Berget, Malin Viktoria Jonsson, Lars Helgeland, Roald Omdal, Roland Jonsson
OBJECTIVE: Germinal center (GC)-like structures have previously been observed in minor salivary glands (MSG) of patients with primary Sjögren syndrome (pSS). The aim of our study was to explore the prevalence and features of GC-like structures and B cell clonality in patients with pSS with and without lymphoma. METHODS: Based on a nationwide survey in Norway, we included 21 patients with pSS and with a concomitant lymphoma from whom MSG and/or lymphoma biopsies were available...
November 2014: Journal of Rheumatology
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