Maurice W Dysken, Mary Sano, Sanjay Asthana, Julia E Vertrees, Muralidhar Pallaki, Maria Llorente, Susan Love, Gerard D Schellenberg, J Riley McCarten, Julie Malphurs, Susana Prieto, Peijun Chen, David J Loreck, George Trapp, Rajbir S Bakshi, Jacobo E Mintzer, Judith L Heidebrink, Ana Vidal-Cardona, Lillian M Arroyo, Angel R Cruz, Sally Zachariah, Neil W Kowall, Mohit P Chopra, Suzanne Craft, Stephen Thielke, Carolyn L Turvey, Catherine Woodman, Kimberly A Monnell, Kimberly Gordon, Julie Tomaska, Yoav Segal, Peter N Peduzzi, Peter D Guarino
IMPORTANCE: Although vitamin E and memantine have been shown to have beneficial effects in moderately severe Alzheimer disease (AD), evidence is limited in mild to moderate AD. OBJECTIVE: To determine if vitamin E (alpha tocopherol), memantine, or both slow progression of mild to moderate AD in patients taking an acetylcholinesterase inhibitor. DESIGN, SETTING, AND PARTICIPANTS: Double-blind, placebo-controlled, parallel-group, randomized clinical trial involving 613 patients with mild to moderate AD initiated in August 2007 and concluded in September 2012 at 14 Veterans Affairs medical centers...
January 1, 2014: JAMA