Keith A Vossel, Maria C Tartaglia, Haakon B Nygaard, Adam Z Zeman, Bruce L Miller
Epileptic activity is frequently associated with Alzheimer's disease; this association has therapeutic implications, because epileptic activity can occur at early disease stages and might contribute to pathogenesis. In clinical practice, seizures in patients with Alzheimer's disease can easily go unrecognised because they usually present as non-motor seizures, and can overlap with other symptoms of the disease. In patients with Alzheimer's disease, seizures can hasten cognitive decline, highlighting the clinical relevance of early recognition and treatment...
April 2017: Lancet Neurology
Hiral Shah, Emiliano Albanese, Cynthia Duggan, Igor Rudan, Kenneth M Langa, Maria C Carrillo, Kit Yee Chan, Yves Joanette, Martin Prince, Martin Rossor, Shekhar Saxena, Heather M Snyder, Reisa Sperling, Mathew Varghese, Huali Wang, Marc Wortmann, Tarun Dua
At the First WHO Ministerial Conference on Global Action Against Dementia in March, 2015, 160 delegates, including representatives from 80 WHO Member States and four UN agencies, agreed on a call for action to reduce the global burden of dementia by fostering a collective effort to advance research. To drive this effort, we completed a globally representative research prioritisation exercise using an adapted version of the Child Health and Nutrition Research Initiative method. We elicited 863 research questions from 201 participants and consolidated these questions into 59 thematic research avenues, which were scored anonymously by 162 researchers and stakeholders from 39 countries according to five criteria...
November 2016: Lancet Neurology
Douglas R Galasko, Elaine Peskind, Christopher M Clark, Joseph F Quinn, John M Ringman, Gregory A Jicha, Carl Cotman, Barbara Cottrell, Thomas J Montine, Ronald G Thomas, Paul Aisen
OBJECTIVE: To evaluate whether antioxidant supplements presumed to target specific cellular compartments affected cerebrospinal fluid (CSF) biomarkers. DESIGN: Double-blind, placebo-controlled clinical trial. SETTING: Academic medical centers. PARTICIPANTS: Subjects with mild to moderate Alzheimer disease. INTERVENTION: Random assignment to treatment for 16 weeks with 800 IU/d of vitamin E (α-tocopherol) plus 500 mg/d of vitamin C plus 900 mg/d of α-lipoic acid (E/C/ALA); 400 mg of coenzyme Q 3 times/d; or placebo...
July 2012: Archives of Neurology
Victor I Reus, Laura J Fochtmann, A Evan Eyler, Donald M Hilty, Marcela Horvitz-Lennon, Michael D Jibson, Oscar L Lopez, Jane Mahoney, Jagoda Pasic, Zaldy S Tan, Cheryl D Wills, Richard Rhoads, Joel Yager
No abstract text is available yet for this article.
May 1, 2016: American Journal of Psychiatry
Lynne Shinto
No abstract text is available yet for this article.
May 31, 2016: Neurology
Yogheswaran Gopalan, Ibrahim Lutfi Shuaib, Enrico Magosso, Mukhtar Alam Ansari, Mohd Rizal Abu Bakar, Jia Woei Wong, Nurzalina Abdul Karim Khan, Wei Chuen Liong, Kalyana Sundram, Bee Hong Ng, Chinna Karuthan, Kah Hay Yuen
BACKGROUND AND PURPOSE: Previous cell-based and animal studies showed mixed tocotrienols are neuroprotective, but the effect is yet to be proven in humans. Thus, the present study aimed to evaluate the protective activity of mixed tocotrienols in humans with white matter lesions (WMLs). WMLs are regarded as manifestations of cerebral small vessel disease, reflecting varying degrees of neurodegeneration and tissue damage with potential as a surrogate end point in clinical trials. METHODS: A total of 121 volunteers aged ≥35 years with cardiovascular risk factors and MRI-confirmed WMLs were randomized to receive 200 mg mixed tocotrienols or placebo twice a day for 2 years...
May 2014: Stroke; a Journal of Cerebral Circulation
F Mangialasche, E Westman, M Kivipelto, J-S Muehlboeck, R Cecchetti, M Baglioni, R Tarducci, G Gobbi, P Floridi, H Soininen, I Kłoszewska, M Tsolaki, B Vellas, C Spenger, S Lovestone, L-O Wahlund, A Simmons, P Mecocci
BACKGROUND: The aim of this study was to evaluate the accuracy of combined structural magnetic resonance imaging (MRI) measures and plasma levels of vitamin E forms, including all eight natural vitamin E congeners (four tocopherols and four tocotrienols) and markers of vitamin E oxidative/nitrosative damage, in differentiating individuals with Alzheimer's disease (AD) and mild cognitive impairment (MCI) from cognitively intact control (CTL) subjects. METHODS: Overall, 81 patients with AD, 86 with MCI and 86 CTL individuals were enrolled from the longitudinal multicentre AddNeuroMed study...
June 2013: Journal of Internal Medicine
Francesca Mangialasche, Alina Solomon, Ingemar Kåreholt, Babak Hooshmand, Roberta Cecchetti, Laura Fratiglioni, Hilkka Soininen, Tiina Laatikainen, Patrizia Mecocci, Miia Kivipelto
BACKGROUND: Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but α-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease. OBJECTIVE: To investigate the association between serum levels of tocopherols and tocotrienols, markers of vitamin E oxidative/nitrosative damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) and incidence of cognitive impairment in a population-based study...
December 2013: Experimental Gerontology
Yonghua Li, Shumei Liu, Yigang Man, Ning Li, Y U Zhou
The aim of the present study was to investigate the effect of vitamins E (VE) and C (VC), combined with β-carotene (β-C), on cognitive function in the elderly. A total of 276 elderly subjects completed the prospective study following treatment with VE, VC and different doses of β-C or with VE only. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale (HDS) tests. The plasma levels of amyloid-β (Aβ) and estradiol (E2 ) were determined by radioimmunoassay (RIA)...
April 2015: Experimental and Therapeutic Medicine
Veronika van der Wardt, Philippa Logan, Victoria Hood, Victoria Booth, Tahir Masud, Rowan Harwood
BACKGROUND/AIMS: Impairment in executive function is associated with a heightened risk for falls in people with mild cognitive impairment (MCI) and dementia. The purpose of this study was to determine which aspects of executive function are associated with falls risk. METHODS: Forty-two participants with a mean age of 81.6 years and a diagnosis of MCI or mild dementia completed five different executive function tests from the computerised CANTAB test battery and a comprehensive falls risk assessment...
2015: Dementia and Geriatric Cognitive Disorders
Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Hironaka Igarashi, Kensaku Kasuga, Yuichi Yokoyama, Takeshi Ikeuchi, Masatoyo Nishizawa, Ingrid L Kwee, Tsutomu Nakada
OBJECTIVE: To investigate whether water influx into cerebrospinal fluid (CSF) space is reduced in Alzheimer's patients as previously shown in the transgenic mouse model for Alzheimer's disease. METHODS: Ten normal young volunteers (young control, 21-30 years old), ten normal senior volunteers (senior control, 60-78 years old, MMSE ≥ 29), and ten Alzheimer's disease (AD) patients (study group, 59-84 years old, MMSE: 13-19) participated in this study. All AD patients were diagnosed by neurologists specializing in dementia based on DSM-IV criteria...
2015: PloS One
Marije R Benedictus, Niels D Prins, Jeroen D C Goos, Philip Scheltens, Frederik Barkhof, Wiesje M van der Flier
IMPORTANCE: Microbleeds are more prevalent in patients with Alzheimer disease (AD) compared with the general elderly population. In addition, microbleeds have been found to predict mortality in AD. OBJECTIVE: To investigate whether microbleeds in AD increase the risk for mortality, stroke (including intracerebral hemorrhage), and cardiovascular events. DESIGN, SETTING AND PARTICIPANTS: The MISTRAL (do MIcrobleeds predict STRoke in ALzheimer's disease) Study is a longitudinal cohort study within the memory clinic-based Amsterdam Dementia Cohort...
May 2015: JAMA Neurology
Ronald B Postuma, Alex Iranzo, Birgit Hogl, Isabelle Arnulf, Luigi Ferini-Strambi, Raffaele Manni, Tomoyuki Miyamoto, Wolfgang Oertel, Yves Dauvilliers, Yo-El Ju, Monica Puligheddu, Karel Sonka, Amelie Pelletier, Juan Santamaria, Birgit Frauscher, Smaranda Leu-Semenescu, Marco Zucconi, Michele Terzaghi, Masayuki Miyamoto, Marcus M Unger, Bertrand Carlander, Maria-Livia Fantini, Jacques Y Montplaisir
OBJECTIVE: To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). METHODS: Twelve centers administered a detailed questionnaire assessing risk factors for neurodegenerative synucleinopathy to patients with idiopathic RBD. Variables included demographics, lifestyle factors, pesticide exposures, occupation, comorbid conditions, medication use, family history, and autonomic/motor symptoms...
May 2015: Annals of Neurology
Shinji Matsunaga, Taro Kishi, Nakao Iwata
OBJECTIVE: To clarify whether memantine is more efficacious in several outcomes and safer than placebo in patients with Lewy body disorders, we performed a meta-analysis of memantine in patients with Lewy body disorders. METHODS: The meta-analysis included randomized controlled trials of memantine for Lewy body disorders in all patients with Lewy body disorders. Motor function, activities of daily living, Neuropsychiatric Inventory, Mini-Mental State Exam, discontinuation rate, and individual side effects were evaluated...
April 2015: American Journal of Geriatric Psychiatry
Yoichiro Takayanagi, Adam P Spira, Roger S McIntyre, William W Eaton
OBJECTIVE: Cognitive function in older adults may be affected by multiple factors, such as sex hormone levels, metabolic disturbances, and neuropsychiatric illness. However, relatively few studies have tested the associations between these factors and cognitive function in a single sample. A cross-sectional analysis was conducted to examine the association between sex hormones, metabolic parameters, and psychiatric diagnoses with verbal memory in nondemented older men. METHODS: Participants were 112 men (mean age: 61...
March 2015: American Journal of Geriatric Psychiatry
Roee Holtzer, Cuiling Wang, Richard Lipton, Joe Verghese
OBJECTIVES: To evaluate whether levels of cognitive reserve (CR), as measured using the Wechsler Adult Intelligence Scale (WAIS)-III vocabulary test, moderated longitudinal associations between cognitive functions and decline in gait speed in a community-based cohort of older adults without dementia, specifically, whether the protective effect of executive function (EF) and episodic memory against decline in gait speed would be greater in individuals with higher CR. DESIGN: Longitudinal (median number of repeated annual gait speed measures, 3; maximum number of visits, 7)...
November 2012: Journal of the American Geriatrics Society
E Grober, R B Lipton, C Hall, H Crystal
OBJECTIVE: To estimate the relative rates of dementia in initially nondemented subjects with and without memory impairment defined by baseline free recall from the Free and Cued Selective Reminding (FCSR) test. BACKGROUND: Our approach to identifying persons at high risk for future dementia is to show the presence of memory impairment not caused by other cognitive deficits by using a memory test that controls attention and cognitive processing. When the conditions of testing are not adequately controlled, prediction is reduced because age-associated memory deficits due to other cognitive deficits are confused with dementia-associated memory deficits...
February 22, 2000: Neurology
Raquel Lemos, Mário R Simões, Beatriz Santiago, Isabel Santana
The International Working Group on Alzheimer's disease (AD) suggested the free and cued selective reminding test (FCSRT) to assess memory, as it showed high sensitivity and specificity in the differentiation of AD from healthy controls and other dementias. The FCSRT involves the use of selective reminding with semantic cueing in memory assessment. This study aims to validate the FCSRT for mild cognitive impairment (MCI) and AD through the analysis of the diagnostic accuracy and the suggestion of cut-off scores...
September 2015: Journal of Neuropsychology
S Auriacombe, C Helmer, H Amieva, C Berr, B Dubois, J-F Dartigues
OBJECTIVE: We assessed the validity of the Free and Cued Selective Reminding Test (FCSRT) in predicting dementia 2 and 5 years after initial evaluation in a population-based cohort over age 65 years participating in the French 3 Cities (3C) study. METHODS: The FCSRT was administered at baseline along with demographics, cognitive and functional scales, and a memory-complaint questionnaire. Two and 5 years later, subjects were assessed for dementia using a 2-stage design...
June 1, 2010: Neurology
Raquel Lemos, Diana Duro, Mário R Simões, Isabel Santana
Memory impairment is often present in frontotemporal dementia (FTD) as a result of an inefficient use of learning strategies, sometimes leading to a misdiagnosis of Alzheimer's disease (AD). The Free and Cued Selective Reminding Test (FCSRT) is a memory test that controls attention and acquisition, by providing category cues in the learning process. The main goal of this study was to show the usefulness of the FCSRT in the distinction between behavioral (bv-) FTD and AD. Three matched subgroups of participants were considered: bv-FTD (n = 32), AD (n = 32), and a control group of healthy adults (n = 32)...
November 2014: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
2015-02-14 17:33:52
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