Takaaki Ito, Ryuichi Kukino, Masakazu Takahara, Miki Tanioka, Yasuhiro Nakamura, Yoshihide Asano, Masatoshi Abe, Takayuki Ishii, Taiki Isei, Yuji Inoue, Shinichi Imafuku, Ryokichi Irisawa, Masaki Ohtsuka, Mikio Ohtsuka, Fumihide Ogawa, Takafumi Kadono, Tamihiro Kawakami, Masakazu Kawaguchi, Takeshi Kono, Masanari Kodera, Keisuke Sakai, Takeshi Nakanishi, Akira Hashimoto, Minoru Hasegawa, Masahiro Hayashi, Manabu Fujimoto, Hiroshi Fujiwara, Takeo Maekawa, Koma Matsuo, Naoki Madokoro, Osamu Yamasaki, Yuichiro Yoshino, Andres Le Pavoux, Takao Tachibana, Hironobu Ihn
Varicose veins are treated at multiple clinical departments, but as patients often visit the dermatology clinic first due to leg ulcers, the present Guidelines for the Management of Lower Leg Ulcers/Varicose Veins were prepared in consideration of the importance of the dermatologist's role. Also, the disease concept of chronic venous insufficiency or chronic venous disorders and the CEAP classification of these disorders are presented. The objective of the present guidelines is to properly guide the diagnosis and treatment of lower leg ulcers/varicose veins by systematically presenting evidence-based recommendations that support clinical decisions...
August 2016: Journal of Dermatology
Bruce E Strober, Robert Bissonnette, David Fiorentino, Alexa B Kimball, Luigi Naldi, Neil H Shear, Kavitha Goyal, Steven Fakharzadeh, Stephen Calabro, Wayne Langholff, Yin You, Claudia Galindo, Seina Lee, Mark G Lebwohl
BACKGROUND: Comparing effectiveness of biologics in real-world settings will help inform treatment decisions. OBJECTIVES: We sought to compare therapeutic responses among patients initiating infliximab, adalimumab, or etanercept versus ustekinumab during the Psoriasis Longitudinal Assessment and Registry (PSOLAR). METHODS: Proportions of patients achieving a Physician Global Assessment score of clear (0)/minimal (1) and mean decrease in percentage of body surface area with psoriasis were evaluated at 6 and 12 months...
May 2016: Journal of the American Academy of Dermatology
Timothy R Walsh, John Efthimiou, Brigitte Dréno
Topical and oral antibiotics are routinely used to treat acne. However, antibiotic resistance is increasing, with many countries reporting that more than 50% of Propionibacterium acnes strains are resistant to topical macrolides, making them less effective. We reviewed the current scientific literature to enable proposal of recommendations for antibiotic use in acne treatment. References were identified through PubMed searches for articles published from January, 1954, to March 7, 2015, using four multiword searches...
March 2016: Lancet Infectious Diseases
J R Ingram, P N Woo, S L Chua, A D Ormerod, N Desai, A C Kai, K Hood, T Burton, F Kerdel, S E Garner, V Piguet
More than 50 interventions have been used to treat hidradenitis suppurativa (HS), and so therapy decisions can be challenging. Our objective was to summarize and appraise randomized controlled trial (RCT) evidence for HS interventions in adults. Searches were conducted in Medline, Embase, CENTRAL, LILACS, five trials registers and abstracts from eight dermatology conferences until 13 August 2015. Two review authors independently assessed study eligibility, extracted data and assessed methodological quality...
May 2016: British Journal of Dermatology
A Nast, C E M Griffiths, R Hay, W Sterry, J L Bolognia
BACKGROUND: In order to facilitate effective communication in dermatology, a clearly defined glossary with precise descriptions is essential. The International League of Dermatological Societies' (ILDS) 'Glossary of basic dermatology lesions' was first published in 1987. A quarter of a century later, the ILDS made the decision to revise and expand this nomenclature. OBJECTIVES: Revision and expansion of an international nomenclature for the description of cutaneous lesions...
June 2016: British Journal of Dermatology
Susan M O'Gorman, Julianne Clowry, Michael Manley, Jackie McCavana, Linda Gray, Ann Kavanagh, Aoife Lally, Paul Collins
IMPORTANCE: Daylight photodynamic therapy using topical methyl 5-aminolevulinic acid (MAL) for actinic keratoses (AKs) is as effective as conventional photodynamic therapy but has the advantage of being almost pain free. Daylight photodynamic therapy, however, requires dry and warm weather conditions. OBJECTIVE: To establish if topical MAL photodynamic therapy using a white light light-emitting diode (LED) lamp is as effective and well-tolerated as daylight photodynamic therapy for the treatment of AKs...
June 1, 2016: JAMA Dermatology
Rony Shreberk-Hassidim, Yuval Ramot, Zvi Gilula, Abraham Zlotogorski
No abstract text is available yet for this article.
February 2016: Journal of the American Academy of Dermatology
Carina M Woodruff, Abbas M Charlie, Kieron S Leslie
Hidradenitis suppurativa is a chronic inflammatory disease of apocrine gland-bearing skin. Although immunologic derangements, genetic predisposition, obesity, and smoking are likely important factors, the pathogenesis of the disease and the effect of available treatments on disease course have not been fully elucidated. In the absence of proper treatment, chronic inflammation results in diffuse scarring and a wide array of complications, including the development of cutaneous squamous cell carcinoma. This severe and chronic disease can have detrimental effects on self-esteem and quality of life...
December 2015: Mayo Clinic Proceedings
Thomas Waitao Chu, Mohammed AlJasser, Aymen Alharbi, Othman Abahussein, Kevin McElwee, Jerry Shapiro
No abstract text is available yet for this article.
August 2015: Journal of the American Academy of Dermatology
Andrew Lee, Jennifer Bradford, Gayle Fischer
IMPORTANCE: Adult vulvar lichen sclerosis (VLS) may be complicated by loss of vulvar structure and vulvar carcinoma. There is a lack of evidence as to the ideal method to maintain long-term remission and prevent complications. OBJECTIVES: To determine whether long-term preventive topical corticosteroid (TCS) treatment of VLS, with a target outcome of induction and maintenance of normal skin texture and color, reduces the risk of vulvar carcinoma, relieves symptoms, improves function, and preserves vulvar architecture, and to evaluate the adverse effects of treatment...
October 2015: JAMA Dermatology
C I Wootton, R P E Cartwright, P Manning, H C Williams
No abstract text is available yet for this article.
February 2014: British Journal of Dermatology
Tara D Rachakonda, Jaskaran S Dhillon, Aleksandra G Florek, April W Armstrong
BACKGROUND: Streptococcal infection is associated with psoriasis onset in some patients. Whether tonsillectomy decreases psoriasis symptoms requires a systematic review of the literature. OBJECTIVE: We sought to determine whether tonsillectomy reduces psoriasis severity through a comprehensive search of over 50 years of literature. METHODS: We searched MEDLINE, CINAHL, Cochrane, EMBASE, Web of Science, and OVID databases (from August 1, 1960, to September 12, 2013) and performed a manual search of selected references...
February 2015: Journal of the American Academy of Dermatology
Nicholas R Fuggle, Walter Bragoli, Anjali Mahto, Mary Glover, Anna E Martinez, Veronica A Kinsler
BACKGROUND: Azathioprine is efficacious in the treatment of severe childhood atopic dermatitis; however, robust data on adverse effects in this population are lacking. OBJECTIVE: We sought to assess adverse effects of azathioprine treatment in a pediatric atopic dermatitis cohort, and make recommendations for monitoring based on these data. METHODS: Blood test results for all 82 children prescribed oral azathioprine for atopic dermatitis in our department between 2010 and 2012 were collated prospectively, and clinical notes were reviewed retrospectively...
January 2015: Journal of the American Academy of Dermatology
Megha M Tollefson, Anna L Bruckner
Atopic dermatitis is a common inflammatory skin condition characterized by relapsing eczematous lesions in a typical distribution. It can be frustrating for pediatric patients, parents, and health care providers alike. The pediatrician will treat the majority of children with atopic dermatitis as many patients will not have access to a pediatric medical subspecialist, such as a pediatric dermatologist or pediatric allergist. This report provides up-to-date information regarding the disease and its impact, pathogenesis, treatment options, and potential complications...
December 2014: Pediatrics
K H Kim
Atopic dermatitis (AD) is clinically very heterogeneous and these differences can cause confusion. Differential diagnosis is also complicated by co-infections, particularly in infancy and early childhood. This paper describes the stages and differential diagnosis during the various stages of childhood. The authors also provide advice on how to distinguish between AD and other disorders together with guidance on tackling common issues with treatment such as steroid phobia.
July 2014: British Journal of Dermatology
Robert Sidbury, Dawn M Davis, David E Cohen, Kelly M Cordoro, Timothy G Berger, James N Bergman, Sarah L Chamlin, Kevin D Cooper, Steven R Feldman, Jon M Hanifin, Alfons Krol, David J Margolis, Amy S Paller, Kathryn Schwarzenberger, Robert A Silverman, Eric L Simpson, Wynnis L Tom, Hywel C Williams, Craig A Elmets, Julie Block, Christopher G Harrod, Wendy Smith Begolka, Lawrence F Eichenfield
Atopic dermatitis is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2% to 3% of adults. This guideline addresses important clinical questions that arise in atopic dermatitis management and care, providing recommendations based on the available evidence. In this third of 4 sections, treatment of atopic dermatitis with phototherapy and systemic immunomodulators, antimicrobials, and antihistamines is reviewed, including indications for use and the risk-benefit profile of each treatment option...
August 2014: Journal of the American Academy of Dermatology
Kate Khorsand, Robert Sidbury
The past year has produced several new clinical guidelines germane to paediatric dermatology, as well as important work related to rheumatologic overlap disorders, psoriasis comorbidities, pigmented lesions and quality of life impact. This review highlights common diagnoses and treatments useful for the practicing paediatrician.
October 2014: Archives of Disease in Childhood
Timothy G Berger, Melissa Shive, G Michael Harper
IMPORTANCE: Pruritus is a common problem among elderly people and, when severe, causes as much discomfort as chronic pain. Little evidence supports pruritus treatment, limiting therapeutic possibilities and resulting in challenging management problems. OBJECTIVES: To present the evidence on the etiology, diagnosis, and treatment of pruritus in the elderly and, using the best available evidence, provide an approach for generalist physicians caring for older patients with pruritus...
December 11, 2013: JAMA
Cliff Rosendahl, Alan Cameron, Giuseppe Argenziano, Iris Zalaudek, Philipp Tschandl, Harald Kittler
OBJECTIVES To characterize dermoscopic criteria of squamous cell carcinoma (SCC) and keratoacanthoma and to compare them with other lesions. DESIGN Observer-masked study of consecutive lesions performed from March 1 through December 31, 2011. SETTING Primary care skin cancer practice in Brisbane, Australia. PARTICIPANTS A total of 186 patients with 206 lesions. MAIN OUTCOME MEASURES Sensitivity, specificity, predictive values, and odds ratios. RESULTS In a retrospective analysis of 60 invasive SCC and 43 keratoacanthoma cases, keratin, surface scale, blood spots, white structureless zones, white circles, and coiled vessels were commonly found in both types of lesions...
December 2012: Archives of Dermatology
C B Archer, S N Cohen, S E Baron
This article discusses the effects of acne (sometimes referred to as acne vulgaris), how to diagnose it confidently and how to distinguish it from rosacea, and the options available for treatment, especially in primary care. We also suggest when referral to dermatology should be considered, and try to anticipate some frequently asked questions.
May 2012: Clinical and Experimental Dermatology
2014-10-04 18:58:35
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