Babak Hooshmand, Johan Lökk, Alina Solomon, Francesca Mangialasche, Julia Miralbell, Gabriela Spulber, Sylvia Annerbo, Niels Andreasen, Bengt Winblad, Angel Cedazo-Minguez, Lars-Olof Wahlund, Miia Kivipelto
BACKGROUND: Low vitamin D status is associated with poorer cognitive function in older adults, but little is known about the potential impact on cerebrospinal fluid (CSF) biomarkers and brain volumes. The objective of this study was to examine the relations between plasma 25-hydroxyvitamin D (25(OH)D) and cognitive impairment, CSF biomarkers of Alzheimer's disease (AD), and structural brain tissue volumes. METHODS: A total of 75 patients (29 with subjective cognitive impairment, 28 with mild cognitive impairment, 18 with AD) referred to the Memory Clinic at Karolinska University Hospital, Huddinge, Sweden were recruited...
September 2014: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences