Mario Castro, Tonya S King, Susan J Kunselman, Michael D Cabana, Loren Denlinger, Fernando Holguin, Shamsah D Kazani, Wendy C Moore, James Moy, Christine A Sorkness, Pedro Avila, Leonard B Bacharier, Eugene Bleecker, Homer A Boushey, James Chmiel, Anne M Fitzpatrick, Deborah Gentile, Mandeep Hundal, Elliot Israel, Monica Kraft, Jerry A Krishnan, Craig LaForce, Stephen C Lazarus, Robert Lemanske, Njira Lugogo, Richard J Martin, David T Mauger, Edward Naureckas, Stephen P Peters, Wanda Phipatanakul, Loretta G Que, Ajay Sheshadri, Lewis Smith, Julian Solway, Lisa Sullivan-Vedder, Kaharu Sumino, Michael E Wechsler, Sally Wenzel, Steven R White, E Rand Sutherland
IMPORTANCE: In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency. OBJECTIVE: To evaluate if vitamin D supplementation would improve the clinical efficacy of inhaled corticosteroids in patients with symptomatic asthma and lower vitamin D levels. DESIGN, SETTING, AND PARTICIPANTS: The VIDA (Vitamin D Add-on Therapy Enhances Corticosteroid Responsiveness in Asthma) randomized, double-blind, parallel, placebo-controlled trial studying adult patients with symptomatic asthma and a serum 25-hydroxyvitamin D level of less than 30 ng/mL was conducted across 9 academic US medical centers in the National Heart, Lung, and Blood Institute's AsthmaNet network, with enrollment starting in April 2011 and follow-up complete by January 2014...
May 2014: JAMA