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https://read.qxmd.com/read/7884951/an-assessment-of-the-safety-of-pediatric-ibuprofen-a-practitioner-based-randomized-clinical-trial
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RANDOMIZED CONTROLLED TRIAL
S M Lesko, A A Mitchell
OBJECTIVE: To test the hypothesis that ibuprofen increases the risk of hospitalization for gastrointestinal bleeding, renal failure, or anaphylaxis among febrile children. DESIGN: Randomized double-blind acetaminophen-controlled trial. SETTING: Outpatient pediatric and family medicine practices. PATIENTS: A total of 84,192 children. INTERVENTION: Patients were randomly assigned to receive 12 mg/kg of acetaminophen, 5 mg/kg of ibuprofen, or 10 mg/kg of ibuprofen...
March 22, 1995: JAMA
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