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By David Bennett Pediatric Orthopaedic Surgeon in the United States
Charalampos G Zalavras, Jay R Lieberman
Osteonecrosis of the femoral head may lead to progressive destruction of the hip joint. Although the etiology of osteonecrosis has not been definitely delineated, risk factors include corticosteroid use, alcohol consumption, trauma, and coagulation abnormalities. Size and location of the lesion are prognostic factors for disease progression and are best assessed by MRI. The efficacy of medical management of osteonecrosis with pharmacologic agents and biophysical modalities requires further investigation. Surgical management is based on patient factors and lesion characteristics...
July 2014: Journal of the American Academy of Orthopaedic Surgeons
Mujtaba Nassiri, Robert A Bruce-Brand, Francis O'Neill, Shojaeddin Chenouri, Paul Curtin
BACKGROUND: Research has shown that up to 89% of parents used the Internet to seek health information regarding their child's medical condition. Much of the information on the Internet is valuable; however, the quality of health information is variable and unregulated. The aim of this study was to evaluate the quality and content of information about Perthes disease on the Internet using recognized scoring systems, identification of quality markers, and describe a novel specific score...
July 2015: Journal of Pediatric Orthopedics
Harry K W Kim, Olumide Aruwajoye, Justin Du, Nobuhiro Kamiya
BACKGROUND: Non-weight-bearing decreases the femoral head deformity but increases bone resorption without increasing bone formation in an experimental animal model of Legg-Calvé-Perthes disease. We sought to determine if local administration of bone morphogenetic protein (BMP)-2 with or without bisphosphonate can increase the bone formation during the non-weight-bearing treatment in the large animal model of Legg-Calvé-Perthes disease. METHODS: Eighteen piglets were surgically induced with femoral head ischemia...
September 17, 2014: Journal of Bone and Joint Surgery. American Volume
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