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Medullary Thyroid Cancer

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By Ehud Ur Professor and Head, Endocrinology, UBC, Vancouver
Maria E Cabanillas, Mimi I Hu, Camilo Jimenez
CONTEXT: Medullary thyroid cancer (MTC) is a rare form of thyroid cancer comprising approximately 4% of all thyroid cancers. The majority of patients have a relatively good prognosis; however, a subgroup of patients will require systemic therapy. Large phase III randomized trials led to the approval of two drugs--vandetanib and cabozantinib--for progressive or symptomatic MTC. The decision regarding which drug to initiate first is not entirely clear and is a common concern amongst treating physicians...
December 2014: Journal of Clinical Endocrinology and Metabolism
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