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Sign Up#41
REVIEW
Ketan K Dhatariya, Nicole S Glaser, Ethel Codner, Guillermo E Umpierrez
Diabetic ketoacidosis (DKA) is the most common acute hyperglycaemic emergency in people with diabetes mellitus. A diagnosis of DKA is confirmed when all of the three criteria are present - 'D', either elevated blood glucose levels or a family history of diabetes mellitus; 'K', the presence of high urinary or blood ketoacids; and 'A', a high anion gap metabolic acidosis. Early diagnosis and management are paramount to improve patient outcomes. The mainstays of treatment include restoration of circulating volume, insulin therapy, electrolyte replacement and treatment of any underlying precipitating event...
May 14, 2020: Nature Reviews. Disease Primers
#42
REVIEW
John A Harvin, Lillian S Kao
PURPOSE OF REVIEW: Acute pain management in the surgical ICU is imperative. Effective acute pain management hastens a patient's return to normal function and avoid the negative sequelae of untreated acute pain. Traditionally, opioids have been the mainstay of acute pain management strategies in the surgical ICU, but alternative medications and management strategies are increasingly being utilized. RECENT FINDINGS: Extrapolating from lessons learned from enhanced recovery after surgery protocols, surgical intensivists are increasingly utilizing multimodal pain regimens (MMPRs) in critically ill surgical patients recovering from major surgical procedures and injuries...
December 2020: Current Opinion in Critical Care
#43
RANDOMIZED CONTROLLED TRIAL
Olivier Hermine, Xavier Mariette, Pierre-Louis Tharaux, Matthieu Resche-Rigon, Raphaël Porcher, Philippe Ravaud
IMPORTANCE: Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19). OBJECTIVE: To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia. DESIGN, SETTING, AND PARTICPANTS: This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating patients with COVID-19 and moderate or severe pneumonia requiring at least 3 L/min of oxygen but without ventilation or admission to the intensive care unit was conducted between March 31, 2020, to April 18, 2020, with follow-up through 28 days...
January 1, 2021: JAMA Internal Medicine
#44
JOURNAL ARTICLE
Effect of Therapeutic Plasma Exchange on Immunoglobulin Deficiency in Early and Severe Septic Shock.
Klaus Stahl, Rolf Bikker, Benjamin Seeliger, Julius J Schmidt, Heiko Schenk, Bernhard M W Schmidt, Tobias Welte, Hermann Haller, Marius M Hoeper, Korbinian Brand, Sascha David
BACKGROUND: Deficiency of immunoglobulins of the classes IgG, IgG1, IgA and IgM is associated with severity of disease and mortality in sepsis and septic shock. Therapeutic plasma exchange (TPE) with fresh frozen plasma (FFP) has recently gained attention as an adjunctive therapeutic option in early septic shock. We hypothesized that TPE might modulate immunoglobulin deficiencies besides sole elimination of circulating injurious molecules. METHODS: We conducted a prospective single center study with TPE in 33 patients with early septic shock (onset < 12 h) requiring high doses of norepinephrine (NE > 0...
December 2021: Journal of Intensive Care Medicine
#45
REVIEW
James E Tisdale, Mina K Chung, Kristen B Campbell, Muhammad Hammadah, Jose A Joglar, Jacinthe Leclerc, Bharath Rajagopalan
Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological drugs, anticancer agents, and many others), can prolong the QT interval and provoke torsades de pointes. Perhaps less familiar to clinicians is the fact that drugs can also trigger other arrhythmias, including bradyarrhythmias, atrial fibrillation/atrial flutter, atrial tachycardia, atrioventricular nodal reentrant tachycardia, monomorphic ventricular tachycardia, and Brugada syndrome...
October 13, 2020: Circulation
#46
REVIEW
Xiaoying Gu, Fei Zhou, Yeming Wang, Guohui Fan, Bin Cao
According to the Third International Consensus Definition for Sepsis and Septic Shock, sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infection. Epidemiological data about sepsis from the 2017 Global Burden of Diseases, Injuries and Risk Factor Study showed that the global burden of sepsis was greater than previously estimated. Bacteria have been shown to be the predominant pathogen of sepsis among patients with pathogens detected, while sepsis caused by viruses is underdiagnosed worldwide...
September 30, 2020: European Respiratory Review: An Official Journal of the European Respiratory Society
#47
JOURNAL ARTICLE
Ryan P Barbaro, Graeme MacLaren, Philip S Boonstra, Theodore J Iwashyna, Arthur S Slutsky, Eddy Fan, Robert H Bartlett, Joseph E Tonna, Robert Hyslop, Jeffrey J Fanning, Peter T Rycus, Steve J Hyer, Marc M Anders, Cara L Agerstrand, Katarzyna Hryniewicz, Rodrigo Diaz, Roberto Lorusso, Alain Combes, Daniel Brodie
BACKGROUND: Multiple major health organisations recommend the use of extracorporeal membrane oxygenation (ECMO) support for COVID-19-related acute hypoxaemic respiratory failure. However, initial reports of ECMO use in patients with COVID-19 described very high mortality and there have been no large, international cohort studies of ECMO for COVID-19 reported to date. METHODS: We used data from the Extracorporeal Life Support Organization (ELSO) Registry to characterise the epidemiology, hospital course, and outcomes of patients aged 16 years or older with confirmed COVID-19 who had ECMO support initiated between Jan 16 and May 1, 2020, at 213 hospitals in 36 countries...
October 10, 2020: Lancet
#48
JOURNAL ARTICLE
Shrinjaya B Thapa, Tanya S Kakar, Corey Mayer, Dilip Khanal
This case series examines outcomes of in-hospital cardiac arrest among patients with COVID-19.
February 1, 2021: JAMA Internal Medicine
#49
EDITORIAL
Sheldon Magder, Douglas Slobod, Nawaporn Assanangkornchai
No abstract text is available yet for this article.
March 1, 2021: American Journal of Respiratory and Critical Care Medicine
#50
REVIEW
Pretty Sara Idiculla, Dhineshreddy Gurala, Manikandan Palanisamy, Rajendran Vijayakumar, Sindhu Dhandapani, Elanagan Nagarajan
BACKGROUND: Cerebral sinus venous thrombosis (CSVT) is a relatively rare, potentially fatal neurological condition that can be frequently overlooked due to the vague nature of its clinical and radiological presentation. A literature search on PubMed using the keyword "Cerebral sinus venous thrombosis" was performed. We searched for the epidemiology, risk factors, pathophysiology, clinical features, diagnosis, and treatment of CSVT. All full-text articles in the last 10 years, in adults (>18 years), and the English language were included...
2020: European Neurology
#51
JOURNAL ARTICLE
Brian T Garibaldi, Jacob Fiksel, John Muschelli, Matthew L Robinson, Masoud Rouhizadeh, Jamie Perin, Grant Schumock, Paul Nagy, Josh H Gray, Harsha Malapati, Mariam Ghobadi-Krueger, Timothy M Niessen, Bo Soo Kim, Peter M Hill, M Shafeeq Ahmed, Eric D Dobkin, Renee Blanding, Jennifer Abele, Bonnie Woods, Kenneth Harkness, David R Thiemann, Mary G Bowring, Aalok B Shah, Mei-Cheng Wang, Karen Bandeen-Roche, Antony Rosen, Scott L Zeger, Amita Gupta
BACKGROUND: Risk factors for progression of coronavirus disease 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts. OBJECTIVE: To determine the factors on hospital admission that are predictive of severe disease or death from COVID-19. DESIGN: Retrospective cohort analysis. SETTING: Five hospitals in the Maryland and Washington, DC, area. PATIENTS: 832 consecutive COVID-19 admissions from 4 March to 24 April 2020, with follow-up through 27 June 2020...
January 2021: Annals of Internal Medicine
#52
RANDOMIZED CONTROLLED TRIAL
Christiane Maria Prado Jeronimo, Maria Eduarda Leão Farias, Fernando Fonseca Almeida Val, Vanderson Souza Sampaio, Marcia Almeida Araújo Alexandre, Gisely Cardoso Melo, Izabella Picinin Safe, Mayla Gabriela Silva Borba, Rebeca Linhares Abreu Netto, Alex Bezerra Silva Maciel, João Ricardo Silva Neto, Lucas Barbosa Oliveira, Erick Frota Gomes Figueiredo, Kelry Mazurega Oliveira Dinelly, Maria Gabriela de Almeida Rodrigues, Marcelo Brito, Maria Paula Gomes Mourão, Guilherme Augusto Pivoto João, Ludhmila Abrahão Hajjar, Quique Bassat, Gustavo Adolfo Sierra Romero, Felipe Gomes Naveca, Heline Lira Vasconcelos, Michel de Araújo Tavares, José Diego Brito-Sousa, Fabio Trindade Maranhão Costa, Maurício Lacerda Nogueira, Djane Clarys Baía-da-Silva, Mariana Simão Xavier, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda
BACKGROUND: Steroid use for coronavirus disease 2019 (COVID-19) is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to evaluate the efficacy of methylprednisolone (MP) among hospitalized patients with suspected COVID-19. METHODS: A parallel, double-blind, placebo-controlled, randomized, Phase IIb clinical trial was performed with hospitalized patients aged ≥18 years with clinical, epidemiological, and/or radiological suspected COVID-19 at a tertiary care facility in Manaus, Brazil...
May 4, 2021: Clinical Infectious Diseases
#53
JOURNAL ARTICLE
Fabio Silvio Taccone, Pierre Alain Gevenois, Lorenzo Peluso, Zoe Pletchette, Olivier Lheureux, Alexandre Brasseur, Alessandra Garufi, Marta Talamonti, Serge Motte, Leda Nobile, David Grimaldi, Jacques Creteur, Jean-Louis Vincent
OBJECTIVES: To assess the role of thromboprophylaxis regimens on the occurrence of pulmonary embolism in coronavirus disease 2019 patients. DESIGN: Retrospective analysis of prospectively collected data on coronavirus disease 2019 patients, included between March 10, and April 30, 2020. SETTING: ICU of an University Hospital in Belgium. PATIENTS AND INTERVENTIONS: Critically ill adult mechanically ventilated coronavirus disease 2019 patients were eligible if they underwent a CT pulmonary angiography, as part of the routine management in case of persistent hypoxemia or respiratory deterioration...
November 2020: Critical Care Medicine
#54
JOURNAL ARTICLE
Gregory W J Hawryluk, Andres M Rubiano, Annette M Totten, Cindy O'Reilly, Jamie S Ullman, Susan L Bratton, Randall Chesnut, Odette A Harris, Niranjan Kissoon, Lori Shutter, Robert C Tasker, Monica S Vavilala, Jack Wilberger, David W Wright, Angela Lumba-Brown, Jamshid Ghajar
When the fourth edition of the Brain Trauma Foundation's Guidelines for the Management of Severe Traumatic Brain Injury were finalized in late 2016, it was known that the results of the RESCUEicp (Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension) randomized controlled trial of decompressive craniectomy would be public after the guidelines were released. The guideline authors decided to proceed with publication but to update the decompressive craniectomy recommendations later in the spirit of "living guidelines," whereby topics are updated more frequently, and between new editions, when important new evidence is published...
September 1, 2020: Neurosurgery
#55
REVIEW
Forbes McGain, Jane Muret, Cathy Lawson, Jodi D Sherman
The detrimental health effects of climate change continue to increase. Although health systems respond to this disease burden, healthcare itself pollutes the atmosphere, land, and waterways. We surveyed the 'state of the art' environmental sustainability research in anaesthesia and critical care, addressing why it matters, what is known, and ideas for future work. Focus is placed upon the atmospheric chemistry of the anaesthetic gases, recent work clarifying their relative global warming potentials, and progress in waste anaesthetic gas treatment...
November 2020: British Journal of Anaesthesia
#56
REVIEW
Rafael Cantón, Desirèe Gijón, Patricia Ruiz-Garbajosa
PURPOSE OF REVIEW: To describe current antimicrobial resistance in ESKAPE Gram-negative microorganisms and their situation in the ICUs, the implication of the so-called high-risk clones (HiRCs) involved in the spread of antimicrobial resistance as well as relevance of the COVID-19 pandemic in the potential increase of resistance. RECENT FINDINGS: Extended-spectrum and carbapenemase producing Enterobacterales and multidrug and extensive drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii have increased worldwide...
October 2020: Current Opinion in Critical Care
#57
JOURNAL ARTICLE
Susan A Olender, Katherine K Perez, Alan S Go, Bindu Balani, Eboni G Price-Haywood, Nirav S Shah, Su Wang, Theresa L Walunas, Shobha Swaminathan, Jihad Slim, BumSik Chin, Stéphane De Wit, Shamim M Ali, Alex Soriano Viladomiu, Philip Robinson, Robert L Gottlieb, Tak Yin Owen Tsang, I-Heng Lee, Hao Hu, Richard H Haubrich, Anand P Chokkalingam, Lanjia Lin, Lijie Zhong, B Nebiyou Bekele, Robertino Mera-Giler, Chloé Phulpin, Holly Edgar, Joel Gallant, Helena Diaz-Cuervo, Lindsey E Smith, Anu O Osinusi, Diana M Brainard, Jose I Bernardino
BACKGROUND: We compared the efficacy of the antiviral agent, remdesivir, versus standard-of-care treatment in adults with severe coronavirus disease 2019 (COVID-19) using data from a phase 3 remdesivir trial and a retrospective cohort of patients with severe COVID-19 treated with standard of care. METHODS: GS-US-540-5773 is an ongoing phase 3, randomized, open-label trial comparing two courses of remdesivir (remdesivir-cohort). GS-US-540-5807 is an ongoing real-world, retrospective cohort study of clinical outcomes in patients receiving standard-of-care treatment (non-remdesivir-cohort)...
December 6, 2021: Clinical Infectious Diseases
#58
REVIEW
Marlies Ostermann, Nuttha Lumlertgul, Lui G Forni, Eric Hoste
Acute kidney injury (AKI) is a serious complication in critically ill patients with COVID-19 with a reported incidence ranging from <5% to >25%. Proposed aetiologies include hypovolemia, hemodynamic disturbance and inflammation but also specific factors like direct viral invasion, microvascular thrombosis, and altered regulation of the renin-angiotensin-aldosterone system. To date, there are no confirmed specific therapies, and prevention and management of AKI should follow established guidelines. Novel therapies specifically targeting COVID-19 related pathologies are under investigation...
December 2020: Journal of Critical Care
#59
REVIEW
Seena Tabibi, Tara Tabibi, Rosalynn R Z Conic, Nassim Banisaeed, Michael B Streiff
In the 5 months since initial reports of COVID-19 came to light, the death toll due to SARS-CoV-2 has rapidly increased. The morbidity and mortality of the infection varies based upon patient age, comorbid conditions, viral load, and the availability of effective treatments. Findings from limited autopsies, clinical observations, and laboratory data suggest that high cytokine levels and a procoagulant state can precipitate acute respiratory distress syndrome and multi-organ dysfunction syndrome in critically ill patients...
September 2020: Journal of Intensive Care Medicine
#60
JOURNAL ARTICLE
Ingrid Egerod, Benjamin Olivares Bøgeskov, Janet F Jensen, Lisa Dahlager, Dorthe Overgaard
BACKGROUND: Life-threatening illness can be devastating for patients as they experience shifting levels of consciousness, recurrent delirium, and repeated setbacks. Narrative Medicine and its sub-discipline Narrative Critical Care increase healthcare professionals' understanding of the patient perspective, and interpretation of their stories is a means to improving practice. PURPOSE: We aimed to investigate book length first-person accounts of critical illness to gain a deeper understanding of universal and individual patient responses and to provide an example of Narrative Critical Care...
October 2020: Journal of Critical Care
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