Ryan P Barbaro, Graeme MacLaren, Philip S Boonstra, Theodore J Iwashyna, Arthur S Slutsky, Eddy Fan, Robert H Bartlett, Joseph E Tonna, Robert Hyslop, Jeffrey J Fanning, Peter T Rycus, Steve J Hyer, Marc M Anders, Cara L Agerstrand, Katarzyna Hryniewicz, Rodrigo Diaz, Roberto Lorusso, Alain Combes, Daniel Brodie
BACKGROUND: Multiple major health organisations recommend the use of extracorporeal membrane oxygenation (ECMO) support for COVID-19-related acute hypoxaemic respiratory failure. However, initial reports of ECMO use in patients with COVID-19 described very high mortality and there have been no large, international cohort studies of ECMO for COVID-19 reported to date. METHODS: We used data from the Extracorporeal Life Support Organization (ELSO) Registry to characterise the epidemiology, hospital course, and outcomes of patients aged 16 years or older with confirmed COVID-19 who had ECMO support initiated between Jan 16 and May 1, 2020, at 213 hospitals in 36 countries...
September 25, 2020: Lancet
Shrinjaya B Thapa, Tanya S Kakar, Corey Mayer, Dilip Khanal
No abstract text is available yet for this article.
September 28, 2020: JAMA Internal Medicine
Sheldon Magder, Douglas Slobod, Nawaporn Assanangkornchai
No abstract text is available yet for this article.
September 30, 2020: American Journal of Respiratory and Critical Care Medicine
Pretty Sara Idiculla, Dhineshreddy Gurala, Manikandan Palanisamy, Rajendran Vijayakumar, Sindhu Dhandapani, Elanagan Nagarajan
BACKGROUND: Cerebral sinus venous thrombosis (CSVT) is a relatively rare, potentially fatal neurological condition that can be frequently overlooked due to the vague nature of its clinical and radiological presentation. A literature search on PubMed using the keyword "Cerebral sinus venous thrombosis" was performed. We searched for the epidemiology, risk factors, pathophysiology, clinical features, diagnosis, and treatment of CSVT. All full-text articles in the last 10 years, in adults (>18 years), and the English language were included...
September 2, 2020: European Neurology
Brian T Garibaldi, Jacob Fiksel, John Muschelli, Matthew L Robinson, Masoud Rouhizadeh, Jamie Perin, Grant Schumock, Paul Nagy, Josh H Gray, Harsha Malapati, Mariam Ghobadi-Krueger, Timothy M Niessen, Bo Soo Kim, Peter M Hill, M Shafeeq Ahmed, Eric D Dobkin, Renee Blanding, Jennifer Abele, Bonnie Woods, Kenneth Harkness, David R Thiemann, Mary G Bowring, Aalok B Shah, Mei-Cheng Wang, Karen Bandeen-Roche, Antony Rosen, Scott L Zeger, Amita Gupta
BACKGROUND: Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts. OBJECTIVE: To determine the factors on hospital admission that are predictive of severe disease or death from COVID-19. DESIGN: Retrospective cohort analysis. SETTING: Five hospitals in the Maryland and Washington, DC, area. PATIENTS: 832 consecutive COVID-19 admissions from 4 March to 24 April 2020, with follow-up through 27 June 2020...
September 22, 2020: Annals of Internal Medicine
Christiane Maria Prado Jeronimo, Maria Eduarda Leão Farias, Fernando Fonseca Almeida Val, Vanderson Souza Sampaio, Marcia Almeida Araújo Alexandre, Gisely Cardoso Melo, Izabella Picinin Safe, Mayla Gabriela Silva Borba, Rebeca Linhares Abreu-Netto, Alex Bezerra Silva Maciel, João Ricardo Silva Neto, Lucas Barbosa Oliveira, Erick Frota Gomes Figueiredo, Kelry Mazurega Oliveira Dinelly, Maria Gabriela de Almeida Rodrigues, Marcelo Brito, Maria Paula Gomes Mourão, Guilherme Augusto Pivoto João, Ludhmila Abrahão Hajjar, Quique Bassat, Gustavo Adolfo Sierra Romero, Felipe Gomes Naveca, Heline Lira Vasconcelos, Michel de Araújo Tavares, José Diego Brito-Sousa, Fabio Trindade Maranhão Costa, Maurício Lacerda Nogueira, Djane Baía-da-Silva, Mariana Simão Xavier, Wuelton Marcelo Monteiro, Marcus Vinícius Guimarães Lacerda
BACKGROUND: Steroid use for COVID-19 is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by SARS-CoV-2. This study aimed at evaluating at evaluating the efficacy of methylprednisolone (MP) among hospitalized patients with suspected COVID-19. METHODS: Parallel, double-blind, placebo-controlled, randomized, phase IIb clinical trial was performed with hospitalized patients aged ≥ 18 years with clinical, epidemiological and/or radiological suspected COVID-19, at a tertiary care facility in Manaus, Brazil...
August 12, 2020: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Fabio Silvio Taccone, Pierre Alain Gevenois, Lorenzo Peluso, Zoe Pletchette, Olivier Lheureux, Alexandre Brasseur, Alessandra Garufi, Marta Talamonti, Serge Motte, Leda Nobile, David Grimaldi, Jacques Creteur, Jean-Louis Vincent
OBJECTIVES: To assess the role of thromboprophylaxis regimens on the occurrence of pulmonary embolism in coronavirus disease 2019 patients. DESIGN: Retrospective analysis of prospectively collected data on coronavirus disease 2019 patients, included between March 10, and April 30, 2020. SETTING: ICU of an University Hospital in Belgium. PATIENTS AND INTERVENTIONS: Critically ill adult mechanically ventilated coronavirus disease 2019 patients were eligible if they underwent a CT pulmonary angiography, as part of the routine management in case of persistent hypoxemia or respiratory deterioration...
November 2020: Critical Care Medicine
Gregory W J Hawryluk, Andres M Rubiano, Annette M Totten, Cindy O'Reilly, Jamie S Ullman, Susan L Bratton, Randall Chesnut, Odette A Harris, Niranjan Kissoon, Lori Shutter, Robert C Tasker, Monica S Vavilala, Jack Wilberger, David W Wright, Angela Lumba-Brown, Jamshid Ghajar
When the fourth edition of the Brain Trauma Foundation's Guidelines for the Management of Severe Traumatic Brain Injury were finalized in late 2016, it was known that the results of the RESCUEicp (Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension) randomized controlled trial of decompressive craniectomy would be public after the guidelines were released. The guideline authors decided to proceed with publication but to update the decompressive craniectomy recommendations later in the spirit of "living guidelines," whereby topics are updated more frequently, and between new editions, when important new evidence is published...
August 6, 2020: Neurosurgery
Forbes McGain, Jane Muret, Cathy Lawson, Jodi D Sherman
The detrimental health effects of climate change continue to increase. Although health systems respond to this disease burden, healthcare itself pollutes the atmosphere, land, and waterways. We surveyed the 'state of the art' environmental sustainability research within anaesthesia and critical care, addressing why it matters, what is known, and ideas for future work. Focus is placed upon the atmospheric chemistry of the anaesthetic gases, recent work clarifying their relative global warming potentials, and progress in waste anaesthetic gas treatment...
August 11, 2020: British Journal of Anaesthesia
Rafael Cantón, Desirèe Gijón, Patricia Ruiz-Garbajosa
PURPOSE OF REVIEW: To describe current antimicrobial resistance in ESKAPE Gram-negative microorganisms and their situation in the ICUs, the implication of the so-called high-risk clones (HiRCs) involved in the spread of antimicrobial resistance as well as relevance of the COVID-19 pandemic in the potential increase of resistance. RECENT FINDINGS: Extended-spectrum and carbapenemase producing Enterobacterales and multidrug and extensive drug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii have increased worldwide...
July 27, 2020: Current Opinion in Critical Care
Susan A Olender, Katherine K Perez, Alan S Go, Bindu Balani, Eboni G Price-Haywood, Nirav S Shah, Su Wang, Theresa L Walunas, Shobha Swaminathan, Jihad Slim, BumSik Chin, Stéphane De Wit, Shamim M Ali, Alex Soriano Viladomiu, Philip Robinson, Robert L Gottlieb, Tak Yin Owen Tsang, I-Heng Lee, Richard H Haubrich, Anand P Chokkalingam, Lanjia Lin, Lijie Zhong, B Nebiyou Bekele, Robertino Mera-Giler, Joel Gallant, Lindsey E Smith, Anu O Osinusi, Diana M Brainard, Hao Hu, Chloé Phulpin, Holly Edgar, Helena Diaz-Cuervo, Jose I Bernardino
BACKGROUND: We compared the efficacy of the antiviral agent, remdesivir, versus standard-of-care treatment in adults with severe COVID-19 using data from a phase 3 remdesivir trial and a retrospective cohort of patients with severe COVID-19 treated with standard-of-care. METHODS: GS-US-540-5773 is an ongoing phase 3, randomized, open-label trial comparing two courses of remdesivir (remdesivir-cohort). GS-US-540-5807 is an ongoing real-world, retrospective cohort study of clinical outcomes in patients receiving standard-of-care treatment (non-remdesivir-cohort)...
July 24, 2020: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Marlies Ostermann, Nuttha Lumlertgul, Lui G Forni, Eric Hoste
Acute kidney injury (AKI) is a serious complication in critically ill patients with COVID-19 with a reported incidence ranging from <5% to >25%. Proposed aetiologies include hypovolemia, hemodynamic disturbance and inflammation but also specific factors like direct viral invasion, microvascular thrombosis, and altered regulation of the renin-angiotensin-aldosterone system. To date, there are no confirmed specific therapies, and prevention and management of AKI should follow established guidelines. Novel therapies specifically targeting COVID-19 related pathologies are under investigation...
July 28, 2020: Journal of Critical Care
Seena Tabibi, Tara Tabibi, Rosalynn R Z Conic, Nassim Banisaeed, Michael B Streiff
In the 5 months since initial reports of COVID-19 came to light, the death toll due to SARS-CoV-2 has rapidly increased. The morbidity and mortality of the infection varies based upon patient age, comorbid conditions, viral load, and the availability of effective treatments. Findings from limited autopsies, clinical observations, and laboratory data suggest that high cytokine levels and a procoagulant state can precipitate acute respiratory distress syndrome and multi-organ dysfunction syndrome in critically ill patients...
July 15, 2020: Journal of Intensive Care Medicine
Ingrid Egerod, Benjamin Olivares Bøgeskov, Janet F Jensen, Lisa Dahlager, Dorthe Overgaard
BACKGROUND: Life-threatening illness can be devastating for patients as they experience shifting levels of consciousness, recurrent delirium, and repeated setbacks. Narrative Medicine and its sub-discipline Narrative Critical Care increase healthcare professionals' understanding of the patient perspective, and interpretation of their stories is a means to improving practice. PURPOSE: We aimed to investigate book length first-person accounts of critical illness to gain a deeper understanding of universal and individual patient responses and to provide an example of Narrative Critical Care...
July 9, 2020: Journal of Critical Care
Seyed MohammadReza Hashemian, Tayebeh Farhadi, Ali Akbar Velayati
INTRODUCTION: Candidemia is the fourth frequent reason of healthcare-related bloodstream infections in critically ill patients. For initial management of (suspected) invasive candidiasis in critically ill patients, usage of an echinocandin, e.g. caspofungin, has been recommended. AREAS COVERED: In this study, characteristics of caspofungin and its use in intensive care unit (ICU) patients are reviewed based on an electronic search using PubMed and Google scholar...
July 23, 2020: Expert Review of Anti-infective Therapy
Akash Deep, Mehak Bansal, Zaccaria Ricci
Children seem to be less severely affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as compared to adults. Little is known about the prevalence and pathogenesis of acute kidney injury (AKI) in children affected by SARS-CoV-2. Dehydration seems to be the most common trigger factor, and meticulous attention to fluid status is imperative. The principles of initiation, prescription, and complications related to renal replacement therapy are the same for coronavirus disease (COVID) patients as for non-COVID patients...
July 14, 2020: Blood Purification
Yiqi Fu, Qing Yang, Min Xu, Haishen Kong, Hongchao Chen, Yajie Fu, Yake Yao, Hua Zhou, Jianying Zhou
Secondary bacterial infections occurred in 13.9% (5 of 36) of critical ill patients with coronavirus disease 2019. All 5 patients had been admitted to intensive care unit and received mechanical ventilation before developing bacterial infection. Active surveillance of culture should be performed for critically ill patients. Prevention of nosocomial infection should to be taken seriously.
June 2020: Open Forum Infectious Diseases
Tarun D Singh, John C O'Horo, Courtney N Day, Jay Mandrekar, Alejandro A Rabinstein
BACKGROUND: Acute encephalopathy (AE) is a common complication of critical illness and is associated with increased short and long-term mortality. In this study, we evaluated the role of cefepime in causing AE. METHODS: Retrospective case-control study involving consecutive patients enrolled in the intensive care units (ICUs) of Mayo Clinic Rochester, MN between July 1, 2004 and December 31, 2015. AE was defined by the presence of delirium or depressed level of consciousness in the absence of deep sedation...
July 1, 2020: Neurocritical Care
Paul J Secombe, Alex Brown, Michael J Bailey, David Pilcher
No abstract text is available yet for this article.
July 2020: Medical Journal of Australia
Prashant Rao, Daniel Katz, Michinari Hieda, Marwa Sabe
The incidence of cardiogenic shock and the utilization of mechanical circulatory support devices are increasing in the US. In this review we discuss the pathophysiology of cardiogenic shock through basic hemodynamic and myocardial energetic principles. We also explore the commonly used platforms for temporary mechanical circulatory support, their advantages, disadvantages and practical considerations relating to implementation and management. It is through the translation of underlying physiological principles that we can attempt to maximize the clinical utility of circulatory support devices and improve outcomes in cardiogenic shock...
July 2020: Heart Failure Clinics
2020-06-08 21:07:31
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