Sarcoidosis | Page 2

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By EFRAIN PAEZ Internal Medicine since 1988. Interested in all aspects of Medicine.
Lindsay J Celada, Wonder P Drake
Sarcoidois is an inflammatory disease of unknown origin characterized by the abnormal accumulation of noncaseating granulomas at sites of disease activity in multiple organs throughout the body with a predilection for the lungs. Because the exact trigger that leads to disease activity is still under investigation, current treatment options are contingent on the organ or organs affected. Corticosteroids are the therapy of choice, but antimalarials and TNF-α antagonists are also commonly prescribed. Recent findings provide evidence for the use of CD20 B-cell-depleting therapy as an alternative method of choice...
2015: Immunotherapy
Yoichi Takaya, Kengo Fukushima Kusano, Kazufumi Nakamura, Hiroshi Ito
Although high-degree atrioventricular block (AVB) is a common initial manifestation of cardiac sarcoidosis, little is known about the outcomes. The aim of this study was to assess outcomes in patients with AVB as an initial manifestation of cardiac sarcoidosis compared with those in patients with ventricular tachyarrhythmia (VT) and/or heart failure (HF). Fifty-three consecutive patients with cardiac sarcoidosis, who had high-degree AVB (n = 22) or VT and/or HF (n = 31), were enrolled. The end point was defined as major adverse cardiac events, including cardiac death, ventricular fibrillation, sustained VT, and hospitalization for HF...
February 15, 2015: American Journal of Cardiology
Riina Kandolin, Jukka Lehtonen, Juhani Airaksinen, Tapani Vihinen, Heikki Miettinen, Kari Ylitalo, Kari Kaikkonen, Suvi Tuohinen, Petri Haataja, Tuomas Kerola, Jorma Kokkonen, Markus Pelkonen, Päivi Pietilä-Effati, Seppo Utrianen, Markku Kupari
BACKGROUND: This study was designed to assess the epidemiology, characteristics, and outcome of cardiac sarcoidosis (CS) in Finland. METHODS AND RESULTS: We identified in retrospect all adult (>18 years of age) patients diagnosed with histologically confirmed CS in Finland between 1988 and 2012. A total of 110 patients (71 women) 51±9 years of age (mean±SD) were found and followed up for outcome events to the end of 2013. The annual detection rate of CS increased >20-fold during the 25-year period, reaching 0...
February 17, 2015: Circulation
Saranya C Balasubramaniam, Diva R Salomão, John B Davies, Robert C Ramsay, Thomas M Habermann, George K Chow, Stephen A Boorjian, Jose S Pulido
BACKGROUND: Sarcoid-like reactions have been reported and confirmed by histopathology in patients with malignant disease. This series demonstrates the complex relationship of malignancy and sarcoidosis as pertaining to the eye, which, to the best of our knowledge, has not been previously reported in the literature. METHODS: Retrospective case study of five patients with sarcoid-like reactions. Patients 1 to 4 represent patients with ocular sarcoid-like reaction and systemic malignant disease...
April 2015: Retina
Sanjay Kumar Mandal, Sudip Ghosh, Soumya Sarathi Mondal, Sumanta Chatterjee
Tuberculosis and sarcoidosis are multisystem diseases having different aetiology and management; however, they have similar clinical and histological characteristics. Very rarely they may coexist. We report a rare case of a 38-year-old woman who presented with chronic cough, low-grade fever and respiratory distress that was initially diagnosed as miliary tuberculosis. Diagnosis was supported by positive mycobacterial culture and initially responded to antitubercular treatment, but later recurrences led to further investigations and the diagnosis of coexisting sarcoidosis...
December 19, 2014: BMJ Case Reports
Brent P Little
No abstract text is available yet for this article.
January 2015: Seminars in Roentgenology
Naciye Sinem Gezer, Işıl Başara, Canan Altay, Mustafa Harman, Laurence Rocher, Nevzat Karabulut, Mustafa Seçil
Sarcoidosis is a multisystem inflammatory disease of unknown etiology. The lungs and the lymphoid system are the most commonly involved organs. Extrapulmonary involvement is reported in 30% of patients, and the abdomen is the most common extrapulmonary site with a frequency of 50%-70%. Although intra-abdominal sarcoidosis is usually asymptomatic, its presence may affect the prognosis and treatment options. The lesions are less characteristic and may mimick neoplastic or infectious diseases such as lymphoma, diffuse metastasis, and granulomatous inflammation...
March 2015: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Dominique Valeyre, Antje Prasse, Hilario Nunes, Yurdagul Uzunhan, Pierre-Yves Brillet, Joachim Müller-Quernheim
Sarcoidosis is a systemic disease of unknown cause that is characterised by the formation of immune granulomas in various organs, mainly the lungs and the lymphatic system. Studies show that sarcoidosis might be the result of an exaggerated granulomatous reaction after exposure to unidentified antigens in individuals who are genetically susceptible. Several new insights have been made, particularly with regards to the diagnosis and care of some important manifestations of sarcoidosis. The indications for endobronchial ultrasound in diagnosis and for PET in the assessment of inflammatory activity are now better specified...
March 29, 2014: Lancet
Magdalena M Martusewicz-Boros, Elzbieta Wiatr, Kazimierz Roszkowski-Sliz
No abstract text is available yet for this article.
2014: Internal Medicine
Sonoko Nagai, Takafumi Yokomatsu, Kiminobu Tanizawa, Kohei Ikezoe, Tomohiro Handa, Yutaka Ito, Shunpei Ogino, Takateru Izumi
No abstract text is available yet for this article.
2014: Internal Medicine
Aysun Yakar, Fatih Yakar, Murat Sezer, Mehmet Bayram, Ezgi Başak Erdoğan, Didem Özkan, Hatice K Özçelik, Levent Tabak
BACKGROUND AND AIM: Sarcoidosis is a multisystem disease of unknown origin. Determining the involvement and the response to the treatment is important. The aim of this study was to identify the effects of methylprednisolone and indomethacine on metabolic activity and pulmonary function test parameters in patients with sarcoidosis. MATERIAL AND METHODS: A total of 24 pulmonary sarcoidosis patients were enrolled in the study. All the patients underwent spirometry and [(18)F]fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) scan before treatment and were divided into two groups according to the necessity of corticosteroid treatment or not...
April 2015: Wiener Klinische Wochenschrift
Danielle Armstrong, Gonzalo V Gonzalez-Stawinski, Jong Mi Ko, Shelley A Hall, William C Roberts
Described herein are clinical and morphologic findings in 2 patients who underwent heart transplantation because of severe heart failure resulting from cardiac sarcoidosis. Although the explanted hearts in each patient had characteristic gross changes of cardiac sarcoidosis, one patient who had been treated with prednisone, had no residual sarcoid granulomas in the myocardium, whereas the other patient, in whom diagnosis was not made until heart transplantation, had innumerable sarcoid granulomas in her heart...
January 1, 2015: American Journal of Cardiology
Brian A Houston, Monica Mukherjee
Sarcoidosis is a multi-system disease pathologically characterized by the accumulation of T-lymphocytes and mononuclear phagocytes into the sine qua non pathologic structure of the noncaseating granuloma. Cardiac involvement remains a key source of morbidity and mortality in sarcoidosis. Definitive diagnosis of cardiac sarcoidosis, particularly early enough in the disease course to provide maximal therapeutic impact, has proven a particularly difficult challenge. However, major advancements in imaging techniques have been made in the last decade...
2014: Clinical Medicine Insights. Cardiology
Sayaka Shibama, Ken Igawa, Takichi Munetsugu, Kunitaro Fukuyama, Aya Nishizawa, Kaoru Takayama, Hiroo Yokozeki
No abstract text is available yet for this article.
December 2014: Annals of Dermatology
Feng Wang, Zhaohui Tong, Zhen Wang, Xiaojuan Wang, Xi Zhan, Huanzhong Shi
Pleural effusion caused by sarcoidosis is unusual. Medical thoracoscopy could help clinicians detect associated pleural disease, yet studies on thoracoscopic observations in sarcoidosis pleural involvement are rare. In this article, we report the utility of medical thoracoscopy in diagnosing sarcoid-related pleural disease for three patients. Pleural nodularity was common with solitary and multiple nodules evident; biopsies confirmed the presence of diagnostic noncaseating granulomas.
September 2014: Respirology Case Reports
Jamak Modaresi Esfeh, Daniel Culver, Thomas Plesec, Binu John
The liver is one of the most commonly involved extrapulmonary sites in sarcoidosis. Hepatic sarcoidosis has a broad range of presentations from scattered, asymptomatic noncaseating granulomas with normal liver enzymes, which are very common in patients with known pulmonary sarcoidosis, to portal hypertension and cirrhosis, which are relatively uncommon. Diagnosis is based on a combination of clinical, laboratory and histological manifestations. The authors' protocol for management of patients with suspected sarcoidosis of the liver without focal lesions includes a transjugular liver biopsy with portal pressure measurements to confirm the diagnosis, rule out coexisting liver diseases and to identify select patients with fibrosis or portal hypertension for consideration of immunosuppression...
March 2015: Expert Review of Gastroenterology & Hepatology
Ayşegül Şentürk, Yüksel Maraş, Emine Argüder, Ayşegül Karalezli, H Canan Hasanoğlu, Tuba Öğüt, Serdal Baştuğ, Ercan Karabekir
Cardiac sarcoidosis is an infiltrative, granulomatous inflammatory disease of the myocardium. Generally, it can be difficult to diagnose cardiac sarcoidosis clinically because of the non-specific nature of its clinical manifestations. This property can be based on the presence of any clinical evidence of sarcoidosis in the other organs. We present two cases of cardiac sarcoidosis so as to demonstrate its different clinical manifestations. The first patient displayed no cardiac symptoms; the electrocardiogram showed an incidental right bundle branch block...
June 2015: Rheumatology International
J Vanderhulst
Gastrointestinal sarcoidosis is a rare form of extrapulmonary sarcoidosis. Most of the cases are represented by gastric involvement. We describe a patient with previous systemic sarcoidosis who presented with non-specific abdominal complaints. The workup showed the unusual combination of isolated active gastric sarcoidosis and quiescent activity of the disease elsewhere. We briefly review the clinical, diagnostic and therapeutic aspects of gastric sarcoidosis. We hope to increase awareness about this rare disease...
February 2015: Acta Clinica Belgica
Memduh Sahin, Güldal Yılmaz, Mehmet Arhan, Ilker Sen
BACKGROUND/AIMS: Granulomas are focal aggregates of modified macrophages that are surrounded by a rim of lymphocytes and fibroblasts. The present study aimed to evaluate the prevalence and etiology of hepatic granulomas (HGs) in the Department of Gastroenterology with a wider population. MATERIALS AND METHODS: We performed a retrospective study on 2662 liver biopsy specimens analyzed between 2005 and 2011 at Gazi University Department of Gastroenterology to determine the presence of HGs...
October 2014: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Federica Vernuccio, Giuseppe Grutta, Giovanni Fazio
Sudden cardiac death (SCD) in athletes is a rare but tragic event particularly considering that in some cases it is preventable. In young athletes with cardiovascular disease the risk of SCD is 2,5 times higher than in non-athletes. In young athletes (<35 years old), the most common causes of SCD are related to pre-existing cardiovascular disorders including hypertrophic cardiomyopathy, congenital coronary anomalies, arrhythmogenic right ventricular dysplasia, commotio cordis, some channelopathies and cardiac sarcoidosis...
November 2014: Recenti Progressi in Medicina
2014-11-29 13:33:26
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