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https://read.qxmd.com/read/38827773/real-world-outcomes-of-faricimab-treatment-for-neovascular-age-related-macular-degeneration-and-diabetic-macular-edema
#1
JOURNAL ARTICLE
Nicole Q X Quah, Khawaja Muhammad Ammar Ali Javed, Lamees Arbi, Daren Hanumunthadu
PURPOSE: The purpose of this study was to assess preliminary real-world outcomes in neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) treated with intravitreal faricimab. PATIENTS AND METHODS: This was a retrospective, observational consecutive-case real-world study of patients with nAMD or DME initiated on intravitreal faricimab between November 2022 and April 2023. Treatment-naïve patients and patients previously treated with alternate anti-vascular endothelial growth factor (anti-VEGF) agents were initiated on an intended treatment plan of four monthly faricimab injections as a loading regime...
2024: Clinical Ophthalmology
https://read.qxmd.com/read/38264181/diabetic-macular-edema-management-a-review-of-anti-vascular-endothelial-growth-factor-vegf-therapies
#2
REVIEW
Abdullah A Cheema, Haider R Cheema
Diabetic macular edema (DME) is a major cause of vision impairment in diabetic individuals, characterized by fluid accumulation in the macula due to a breakdown of the blood-retinal barrier (BRB). This review article explores the role of anti-vascular endothelial growth factor (anti-VEGF) therapies in the management of DME. Anti-VEGF treatments, including ranibizumab, bevacizumab, and aflibercept, have revolutionized DME management by targeting VEGF, a key mediator in DME pathogenesis. We critically examined the efficacy of these therapies in reducing macular edema and improving visual acuity, assessed their safety and tolerability, and explored the variability in treatment response...
January 2024: Curēus
https://read.qxmd.com/read/37980398/intravitreal-anti-vascular-endothelial-growth-factor-injections-in-pregnancy-and-breastfeeding-a-case-series-and-systematic-review-of-the-literature
#3
JOURNAL ARTICLE
Ariel Yuhan Ong, Christine A Kiire, Charlotte Frise, Yasmin Bakr, Samantha R de Silva
INTRODUCTION: Anti-vascular endothelial growth factor (anti-VEGF) agents may occasionally need to be considered for sight-threatening macular pathology in pregnant and breastfeeding women. This is controversial due to the dearth of data on systemic side effects for mother and child. We aimed to expand the evidence base to inform management. METHODS: Retrospective case series of pregnant and breastfeeding women treated with intravitreal anti-VEGF injections at Oxford Eye Hospital between January 2015 and December 2022...
April 2024: Eye
https://read.qxmd.com/read/36788362/giant-cell-arteritis-reviewing-the-advancing-diagnostics-and-management
#4
REVIEW
Edward J Bilton, Susan P Mollan
Giant Cell Arteritis (GCA) is well known to be a critical ischaemic disease that requires immediate medical recognition to initiate treatment and where one in five people still suffer visual loss. The immunopathophysiology has continued to be characterised, and the influencing of ageing in the development of GCA is beginning to be understood. Recent national and international guidelines have supported the directed use of cranial ultrasound to reduce diagnostic delay and improve clinical outcomes. Immediate high dose glucocorticoids remain the standard emergency treatment for GCA, with a number of targeted agents that have been shown in clinical trials to have superior clinical efficacy and steroid sparing effects...
August 2023: Eye
https://read.qxmd.com/read/36709219/analysis-of-microbial-keratitis-incidence-isolates-and-in-vitro-antimicrobial-susceptibility-in-the-east-of-england-a-6-year-study
#5
JOURNAL ARTICLE
Malik Moledina, Harry W Roberts, Achyut Mukherjee, David Spokes, Dimitris Pimenides, Christopher Stephenson, Ramy Bassily, Madhavan S Rajan, James Myerscough
BACKGROUND/OBJECTIVES: To report the incidence, microbiological profile and in-vitro antimicrobial susceptibilities of microbial keratitis (MK) in the East of England (EoE) over a 6-year period. SUBJECTS/METHODS: A retrospective study of patients diagnosed with MK who underwent corneal scraping at participating trusts, within the EoE, between 01/01/2015-01/07/2020. Analysis was performed on MK isolate profiles, in-vitro anti-microbial sensitivities and trends over time...
September 2023: Eye
https://read.qxmd.com/read/36653595/evaluation-of-standard-of-care-intravitreal-aflibercept-treatment-practices-in-patients-with-diabetic-macular-oedema-in-the-uk-drako-study-outcomes
#6
COMMENT
Sobha Sivaprasad, Faruque Ghanchi, Simon P Kelly, Ajay Kotagiri, James Talks, Peter Scanlon, Hellen McGoey, Andrew Nolan, Moneeb Saddiq, Jackie Napier, Peter Morgan-Warren
BACKGROUND/OBJECTIVES: DRAKO (NCT02850263) was a 24-month, prospective, non-interventional, multi-centre cohort study enrolling patients with diabetic macular oedema (DMO) including central involvement. The study evaluated UK standard-of-care intravitreal aflibercept (IVT-AFL) treatment. This analysis describes the treatment pathway and service provision for the anti-vascular endothelial growth factor (VEGF) treatment-naïve (C1) and non-naïve patients (C2) who received prior anti-VEGF treatment for DMO other than IVT-AFL...
August 2023: Eye
https://read.qxmd.com/read/36636621/polypoidal-choroidal-vasculopathy-an-update-on-diagnosis-and-treatment
#7
REVIEW
Parveen Sen, George Manayath, Daraius Shroff, Vineeth Salloju, Priyanka Dhar
Polypoidal choroidal vasculopathy (PCV) is a vascular disease of the choroid that leads to hemorrhagic and exudative macular degeneration. It may cause significant vision loss and thus affect the quality-of-life and psychological well-being. Non-invasive, non-ICGA-based OCT criteria have shown reliable results to plan adjunct photodynamic therapy (PDT) treatment, with the complete and consistent coverage of polypoidal lesions (PL) and branching neovascular network (BNN). The safety and efficacy of anti-vascular endothelial growth factor (anti-VEGF) monotherapy and its combination with verteporfin PDT have been established...
2023: Clinical Ophthalmology
https://read.qxmd.com/read/35644256/laser-treatment-for-choroidal-melanoma-current-concepts
#8
REVIEW
Abhilasha Maheshwari, Paul T Finger
Laser treatment has offered a relatively nonsurgical alternative for eye, life, and vision-sparing treatment of malignant melanoma of the choroid. Historically, the most commonly used forms of lasers were xenon-arc, argon laser, krypton laser, and the more recent transpupillary thermotherapy (TTT) and photodynamic therapy (PDT). Melanomas selected for laser treatment tend to be smaller and visibly accessible, which means these tumors are usually located in the posterior choroid. Laser treatments have been associated with both local tumor destruction and side effects...
2023: Survey of Ophthalmology
https://read.qxmd.com/read/36150481/shot-in-the-dark
#9
REVIEW
M Tariq Bhatti, Aubrey L Gilbert, George Watson, Mark Waheed, Doran Spencer
A 43-year-old woman presented with decreased vision in the right eye associated with painful eye movements 10 days after receiving her first dose of Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine (Pfizer Inc, New York, NY). Two days later she developed painful loss of vision in the left eye. Clinical presentation and magnetic resonance imaging findings were consistent with bilateral optic perineuritis transitioning to optic neuritis. Extensive evaluation including aquaporin-4 immunoglobin G (IgG), myelin oligodendrocyte glycoprotein IgG, and lumbar puncture was unrevealing...
2023: Survey of Ophthalmology
https://read.qxmd.com/read/36526863/optical-coherence-tomography-imaging-biomarkers-associated-with-neovascular-age-related-macular-degeneration-a-systematic-review
#10
REVIEW
Rachel L W Hanson, Archana Airody, Sobha Sivaprasad, Richard P Gale
UNLABELLED: The aim of this systematic literature review is twofold, (1) detail the impact of retinal biomarkers identifiable via optical coherence tomography (OCT) on disease progression and response to treatment in neovascular age-related macular degeneration (nAMD) and (2) establish which biomarkers are currently identifiable by artificial intelligence (AI) models and the utilisation of this technology. Following the PRISMA guidelines, PubMed was searched for peer-reviewed publications dated between January 2016 and January 2022...
December 16, 2022: Eye
https://read.qxmd.com/read/36117281/efficacy-and-safety-of-brolucizumab-in-age-related-macular-degeneration-a-systematic-review-of-real-world-studies
#11
REVIEW
Caroline R Baumal, Torben Lykke Sørensen, Helene Karcher, Rita L Freitas, Anja Becher, Sébastien Balez, Andreas Clemens, Michael Singer, Laurent Kodjikian
Intravitreally injected anti-vascular endothelial growth factor (anti-VEGF) agents are first-line treatment for neovascular age-related macular degeneration (nAMD). Phase 3 trials demonstrated non-inferiority of anti-VEGF therapy with brolucizumab compared with aflibercept in best corrected visual acuity (BCVA) gains, with superior anatomical outcomes after brolucizumab. The purpose of the review was to summarize real-world efficacy and safety data on brolucizumab in patients with nAMD. The review protocol was registered with PROSPERO (ID: CRD42021290530)...
March 2023: Acta Ophthalmologica
https://read.qxmd.com/read/36178171/comparative-efficacy-of-treatments-for-chronic-central-serous-chorioretinopathy-a-systematic-review-with-network-meta-analyses
#12
REVIEW
Elon H C van Dijk, Helena M A Feenstra, Jakob Bjerager, Jakob Grauslund, Camiel J F Boon, Yousif Subhi
Treatment of chronic central serous chorioretinopathy (cCSC) remains a topic of controversy. As cCSC is a disease that can wax and wane, treatment efficacy is difficult to assess especially when trials compare active treatments without any placebo/control group. In this study, we systematically reviewed short-term efficacies of any cCSC treatment tested in randomized controlled trials (RCT) and employed network meta-analyses to compare to non-treatment controls. We searched 11 literature databases on 20 March 2022 for RCTs of treatment of cCSC...
March 2023: Acta Ophthalmologica
https://read.qxmd.com/read/36557072/a-review-of-neovascular-glaucoma-etiology-pathogenesis-diagnosis-and-treatment
#13
REVIEW
Danielė Urbonavičiūtė, Dovilė Buteikienė, Ingrida Janulevičienė
Neovascular glaucoma (NVG) is a rare, aggressive, blinding secondary glaucoma, which is characterized by neovascularization of the anterior segment of the eye and leading to elevation of the intraocular pressure (IOP). The main etiological factor is retinal ischemia leading to an impaired homeostatic balance between the angiogenic and antiangiogenic factors. High concentrations of vasogenic substances such as vascular endothelial growth factor (VEGF) induce neovascularization of the iris (NVI) and neovascularization of the angle (NVA) that limits the outflow of aqueous humor from the anterior chamber and increases the IOP...
December 18, 2022: Medicina
https://read.qxmd.com/read/36380090/a-nationwide-survey-of-hydroxychloroquine-retinopathy-presenting-to-the-hospital-eye-service-in-the-united-kingdom
#14
JOURNAL ARTICLE
Imran H Yusuf, Ruofan C Han, Susan M Downes, Srilakshmi M Sharma
BACKGROUND: The risk of developing hydroxychloroquine retinopathy is considered sufficient to justify national monitoring programmes. There are an estimated 71,144-77,170 long-term hydroxychloroquine users in the UK. However, the number of patients diagnosed with retinopathy is unknown. This study aimed to identify the number of cases and clinical characteristics of hydroxychloroquine retinopathy diagnosed annually in hospital eye services across the UK. METHODS: A nationwide, prospective case ascertainment study was undertaken using the British Ophthalmological Surveillance Unit, which sends approximately 1420 reporting cards to UK Ophthalmologists monthly...
November 15, 2022: Eye
https://read.qxmd.com/read/36233408/topical-nsaids-and-oral-acetazolamide-for-macular-edema-after-uncomplicated-phacoemulsification-outcome-and-predictors-of-non-response
#15
JOURNAL ARTICLE
Wissam Aljundi, Loay Daas, Yaser Abu Dail, Barbara Käsmann-Kellner, Berthold Seitz, Alaa Din Abdin
PURPOSE: To investigate the effectiveness of nonsteroidal anti-inflammatory eye drops (NSAIDs) combined with oral acetazolamide for postoperative macular edema (PME) after uncomplicated phacoemulsification (PE) and identify predictors of non-response. METHODS: We analyzed data of uncomplicated PE and identified eyes with PME. First-line therapy included topical NSAIDs combined with oral acetazolamide. In the case of non-response, triamcinolone was administered subtenonally...
September 21, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36161828/frequency-and-timing-of-antivascular-endothelial-growth-factor-treatment-for-eyes-with-centre-involved-diabetic-macular-oedema-and-good-vision-protocol-v-results-in-context
#16
EDITORIAL
Diana V Do, Hadi Moini, Charles C Wykoff
No abstract text is available yet for this article.
August 2022: BMJ Open Ophthalmology
https://read.qxmd.com/read/36160091/atypical-refractory-macular-edema-are-we-missing-something
#17
Chaitra Jayadev, Ishank Gupta, Santosh Gopi Krishna Gadde
Purpose: To report a case of bilateral refractory macular edema in a diabetic macular edema in a diabetic with an underlying systemic illness. Case Report: A 65-year-old male presented with the symptom of blurred vision in both eyes for three months. He was a known diabetic patient and was also hypertensive for the last 10 years. The corrected distance visual acuity was 20/120 in the right eye and 20/80 in the left eye. Fundus examination revealed multiple deep and superficial retinal hemorrhages, cystoid macular edema, and serous macular detachment in both eyes...
July 2022: Journal of Ophthalmic & Vision Research
https://read.qxmd.com/read/36118279/posterior-scleritis-after-biweekly-aflibercept-intravitreal-injections
#18
Mélanie Hébert, Eunice You, Jean-François Gravel, Ali Dirani, Serge Bourgault
PURPOSE: To describe a case of posterior scleritis following anti-vascular endothelial growth factor (VEGF) injection. OBSERVATIONS: A 51-year-old male receiving biweekly anti-VEGF injections for a central retinal vein occlusion complicated with cystoid macular edema presented with new-onset severe pain, photophobia, and tearing. Ophthalmological examination revealed choroidal folds and B-scan ultrasound confirmed significant thickening of the sclera, leading to a diagnosis of posterior scleritis...
December 2022: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/35869478/mycobacterium-chimaera-chorioretinitis-preceding-central-nervous-system-lesions-a-case-report-and-review-of-the-literature
#19
REVIEW
Aaron Veenis, Megan Haghnegahdar, Radwan Ajlan
BACKGROUND: Mycobacterium chimaera ocular infection is a rare disease that is linked to bypass devices used during cardiothoracic surgeries. Reported cases in the literature of ocular involvement preceding CNS involvement are based on clinical exam with no neuroimaging. Here we present a case of M. chimaera ocular infection with no CNS M. chimaera lesions on brain magnetic resonance imaging (MRI). CASE PRESENTATION: A 59-year-old female presented with altered mental status and blurred vision in February 2021...
July 22, 2022: BMC Ophthalmology
https://read.qxmd.com/read/35883109/bilateral-posterior-scleritis-after-sequential-bilateral-cataract-surgery-a-case-report
#20
JOURNAL ARTICLE
Chae-Min Hong, Min-Ho Shin, Seong-Jae Kim, Seong-Wook Seo, Inyoung Chung, Woong-Sun Yoo
BACKGROUND: Posterior scleritis is a rare, inflammatory ophthalmic disease, leading to severe visual impairment if untreated. Posterior scleritis occurring after surgery, unrelated to systemic inflammatory diseases, is even rarer. This report discusses a case of bilateral posterior scleritis, after cataract surgery in both the eyes, treated with high-dose steroids. CASE PRESENTATION: A 55-year-old man, who had undergone bilateral sequential cataract surgery one week before, presented with sudden loss of vision and ocular pain in both eyes...
July 26, 2022: BMC Ophthalmology
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