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In Gyu Kwon, Tae Kyung Ha, Seung-Wan Ryu, Eunyoung Ha
BACKGROUND: MicroRNAs (miRNAs) are endogenous noncoding small ribonucleic acids that have emerged as one of the central players of gene expression regulation. This study was designed to determine and identify miRNAs that are associated with Roux-en-Y gastric bypass (RYGB). METHODS: Male Sprague-Dawley rats were divided into two groups: sham and RYGB. Changes in food intake and body weight were measured. miRNA microarray analyses on the brain hypothalamus and heart were performed...
December 2015: Journal of Surgical Research
Anita P Courcoulas, Steven H Belle, Rebecca H Neiberg, Sheila K Pierson, Jessie K Eagleton, Melissa A Kalarchian, James P DeLany, Wei Lang, John M Jakicic
IMPORTANCE: Questions remain about the role and durability of bariatric surgery for type 2 diabetes mellitus (T2DM). OBJECTIVE: To compare the remission of T2DM following surgical and nonsurgical treatments. DESIGN, SETTING, AND PARTICIPANTS: In this 3-arm randomized clinical trial conducted at the University of Pittsburgh Medical Center from October 1, 2009, to June 26, 2014, in Pittsburgh, Pennsylvania, outcomes were assessed 3 years after treating 61 obese participants aged 25 to 55 years with T2DM...
October 2015: JAMA Surgery
E C Lopes, I Heineck, G Athaydes, N G Meinhardt, K E P Souto, A T Stein
The aim of this study was to assess drug use and costs before and after bariatric surgery (BS). A systematic review of the literature was carried out using the MeSH terms obesity, bariatric surgery, and drug costs for searches of 10 electronic databases up to July 2014. Data were extracted from the 11 studies (37,720 patients) that fulfilled the inclusion criteria. Where applicable, data were pooled by meta-analysis. The average number of drugs per patient decreased from 3.9 ± 1.86 before surgery to 1.75 ± 1...
September 2015: Obesity Surgery
Gema Frühbeck
The obesity epidemic, combined with the lack of available and effective treatments for morbid obesity, is a scientific and public health priority. Worldwide, bariatric and metabolic surgeries are increasingly being performed to effectively aid weight loss in patients with severe obesity, as well as because of the favourable metabolic effects of the procedures. The positive effects of bariatric surgery, especially with respect to improvements in type 2 diabetes mellitus, have expanded the eligibility criteria for metabolic surgery to patients with diabetes mellitus and a BMI of 30-35 kg/m(2)...
August 2015: Nature Reviews. Endocrinology
Sayeed Ikramuddin, Judith Korner, Wei-Jei Lee, John E Connett, William B Inabnet, Charles J Billington, Avis J Thomas, Daniel B Leslie, Keong Chong, Robert W Jeffery, Leaque Ahmed, Adrian Vella, Lee-Ming Chuang, Marc Bessler, Michael G Sarr, James M Swain, Patricia Laqua, Michael D Jensen, John P Bantle
IMPORTANCE: Controlling glycemia, blood pressure, and cholesterol is important for patients with diabetes. How best to achieve this goal is unknown. OBJECTIVE: To compare Roux-en-Y gastric bypass with lifestyle and intensive medical management to achieve control of comorbid risk factors. DESIGN, SETTING, AND PARTICIPANTS: A 12-month, 2-group unblinded randomized trial at 4 teaching hospitals in the United States and Taiwan involving 120 participants who had a hemoglobin A1c (HbA1c) level of 8...
June 5, 2013: JAMA: the Journal of the American Medical Association
Graziella Bruno, Gabriella Gruden, Federica Barutta, Paolo Cavallo Perin, Mario Morino, Mauro Toppino
BACKGROUND: Effectiveness of sleeve gastrectomy and gastric bypass on glycemic, blood pressure, and lipids control in obese type 2 diabetic patients is poorly known. OBJECTIVE: To assess the effectiveness of bariatric surgery on obese patients with type 2 diabetes. SETTING: University hospital, Italy. METHODS: Diabetes remission and metabolic changes over postoperative follow-up were assessed in 135 obese patients with type 2 diabetes who underwent bariatric surgery in 2007-2011 (gastric bypass, n = 100; sleeve gastrectomy, n = 35)...
September 2015: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Kajsa Sjöholm, Pia Pajunen, Peter Jacobson, Kristjan Karason, C David Sjöström, Jarl Torgerson, Lena M S Carlsson, Lars Sjöström, Markku Peltonen
AIMS/HYPOTHESIS: The aim of this work was to analyse the rates of incidence and remission of type 2 diabetes in relation to baseline BMI and weight change in the prospective, controlled Swedish Obese Subjects (SOS) study. METHODS: Three-thousand four-hundred and eighty-five obese individuals receiving bariatric surgery or conventional treatment were grouped into four baseline BMI categories (<35, 35-40, 40-45 or ≥ 45 kg/m(2)) and five weight-change categories according to their BMI at 2 years (increase [≥ 1 BMI unit increase], no change [less than 1 BMI unit change], minor reduction [-1 to -9 BMI units], medium reduction [-10 to -14 BMI units] and major reduction [< -15 BMI units])...
July 2015: Diabetologia
Alexander D Miras, Ling Ling Chuah, Nofal Khalil, Alessia Nicotra, Amoolya Vusirikala, Najah Baqai, Christopher Graham, Saranya Ravindra, Gerassimos Lascaratos, Nick Oliver, Carel W le Roux
AIMS/HYPOTHESIS: We aimed to examine the effects of bariatric surgery on microvascular complications in patients with type 2 diabetes using objective measures. METHODS: Prospective case-control study of 70 obese surgical patients with type 2 diabetes undergoing gastric bypass surgery matched for age, sex and duration of diabetes to 25 medical patients treated using international guidelines. Microvascular complications were assessed before and 12-18 months after intervention using urine albumin creatinine ratio (ACR) measurements, two-field digital retinal images and peripheral nerve conduction studies (in the surgical group only)...
July 2015: Diabetologia
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