Charles H Kellner, Rebecca G Knapp, Georgios Petrides, Teresa A Rummans, Mustafa M Husain, Keith Rasmussen, Martina Mueller, Hilary J Bernstein, Kevin O'Connor, Glenn Smith, Melanie Biggs, Samuel H Bailine, Chitra Malur, Eunsil Yim, Shawn McClintock, Shirlene Sampson, Max Fink
BACKGROUND: Although electroconvulsive therapy (ECT) has been shown to be extremely effective for the acute treatment of major depression, it has never been systematically assessed as a strategy for relapse prevention. OBJECTIVE: To evaluate the comparative efficacy of continuation ECT (C-ECT) and the combination of lithium carbonate plus nortriptyline hydrochloride (C-Pharm) in the prevention of depressive relapse. DESIGN: Multisite, randomized, parallel design, 6-month trial performed from 1997 to 2004...
December 2006: Archives of General Psychiatry