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Psychogenomics
Psychogenomics
• GWAS? SNP? Psychopharmacogenomics? Gut microbiomes? Metagenomics?
#21
JOURNAL ARTICLE
Michael J Ostacher, Dan V Iosifescu, Aleena Hay, Sarah R Blumenthal, Pamela Sklar, Roy H Perlis
OBJECTIVES: Motivated by genetic association data implicating L-type calcium channels in bipolar disorder liability, we sought to estimate the tolerability, safety, and efficacy of isradipine in the adjunctive treatment of bipolar depression. METHODS: A total of 12 patients with bipolar I or II depression entered this pilot, proof-of-concept eight-week investigation and 10 returned for at least one post-baseline visit. They were initiated on isradipine at 2.5 mg and titrated up to 10 mg daily, with blinded assessments of depression using the Montgomery-Åsberg Depression Rating Scale (MADRS) as well as adverse effects...
March 2014: Bipolar Disorders
#22
JOURNAL ARTICLE
Kenneth S Kendler, Michael C O'Donovan
No abstract text is available yet for this article.
December 1, 2014: JAMA Psychiatry
#23
JOURNAL ARTICLE
Enda M Byrne, Uttam K Raheja, Sarah H Stephens, Andrew C Heath, Pamela A F Madden, Dipika Vaswani, Gagan V Nijjar, Kathleen A Ryan, Hassaan Youssufi, Philip R Gehrman, Alan R Shuldiner, Nicholas G Martin, Grant W Montgomery, Naomi R Wray, Elliot C Nelson, Braxton D Mitchell, Teodor T Postolache
OBJECTIVE: To test common genetic variants for association with seasonality (seasonal changes in mood and behavior) and to investigate whether there are shared genetic risk factors between psychiatric disorders and seasonality. METHOD: Genome-wide association studies (GWASs) were conducted in Australian (between 1988 and 1990 and between 2010 and 2013) and Amish (between May 2010 and December 2011) samples in whom the Seasonal Pattern Assessment Questionnaire (SPAQ) had been administered, and the results were meta-analyzed in a total sample of 4,156 individuals...
February 2015: Journal of Clinical Psychiatry
#24
JOURNAL ARTICLE
Rohan H C Palmer, Leslie Brick, Nicole R Nugent, L Cinnamon Bidwell, John E McGeary, Valerie S Knopik, Matthew C Keller
BACKGROUND AND AIMS: Twin and family studies suggest that genetic influences are shared across substances of abuse. However, despite evidence of heritability, genome-wide association and candidate gene studies have indicated numerous markers of limited effects, suggesting that much of the heritability remains missing. We estimated (1) the aggregate effect of common single nucleotide polymorphisms (SNPs) on multiple indicators of comorbid drug problems that are typically employed across community and population-based samples, and (2) the genetic covariance across these measures...
March 2015: Addiction
#25
JOURNAL ARTICLE
Alexis C Edwards, Fazil Aliev, Aaron R Wolen, Jessica E Salvatore, Charles O Gardner, George McMahon, David M Evans, John Macleod, Matthew Hickman, Danielle M Dick, Kenneth S Kendler
AIMS: Alcohol problems (AP) contribute substantially to the global disease burden. Twin and family studies suggest that AP are genetically influenced, although few studies have identified variants or genes that are robustly associated with risk. This study identifies genetic and genomic influences on AP during young adulthood, which is often when drinking habits are established. DESIGN: We conducted a genome-wide association study of AP. We further conducted gene-based tests, gene ontology analyses and functional genomic enrichment analyses to assess genomic factors beyond single variants that are relevant to AP...
March 2015: Addiction
#26
JOURNAL ARTICLE
Shaw-Ji Chen, Yu-Lin Chao, Chuan-Yu Chen, Chia-Ming Chang, Erin Chia-Hsuan Wu, Chi-Shin Wu, Hsueh-Han Yeh, Chia-Hsiang Chen, Hui-Ju Tsai
BACKGROUND: The association between autoimmune diseases and schizophrenia has rarely been systematically investigated. AIMS: To investigate the association between schizophrenia and a variety of autoimmune diseases and to explore possible gender variation in any such association. METHOD: Taiwan's National Health Insurance Research Database was used to identify 10 811 hospital in-patients with schizophrenia and 108 110 age-matched controls...
May 2012: British Journal of Psychiatry
#27
JOURNAL ARTICLE
Carl Sellgren, Thomas Frisell, Paul Lichtenstein, Mikael Landèn, Johan Askling
Numerous studies have reported a reduced risk of rheumatoid arthritis (RA) in schizophrenia. The mechanisms are unknown, but recent genome-wide association studies of schizophrenia have shown strong associations with markers spanning the major histocompatibility complex region, indicating a possible role for adaptive immunity also in schizophrenia. In this population-based cohort study, we assess the associations between RA and schizophrenia and the extent to which any observed associations are specific to RA/schizophrenia...
November 2014: Schizophrenia Bulletin
#28
JOURNAL ARTICLE
Lynn M Almli, Richard Duncan, Hao Feng, Debashis Ghosh, Elisabeth B Binder, Bekh Bradley, Kerry J Ressler, Karen N Conneely, Michael P Epstein
IMPORTANCE: Genetic association studies of psychiatric outcomes often consider interactions with environmental exposures and, in particular, apply tests that jointly consider gene and gene-environment interaction effects for analysis. Using a genome-wide association study (GWAS) of posttraumatic stress disorder (PTSD), we report that heteroscedasticity (defined as variability in outcome that differs by the value of the environmental exposure) can invalidate traditional joint tests of gene and gene-environment interaction...
December 1, 2014: JAMA Psychiatry
#29
JOURNAL ARTICLE
Ming T Tsuang, Joyce van de Leemput
No abstract text is available yet for this article.
October 1, 2014: American Journal of Psychiatry
#30
REVIEW
Lingjun Zuo, Lingeng Lu, Yunlong Tan, Xinghua Pan, Yiqiang Cai, Xiaoping Wang, Jiang Hong, Chunlong Zhong, Fei Wang, Xiang-Yang Zhang, Lauren A Vanderlinden, Boris Tabakoff, Xingguang Luo
OBJECTIVE: To report the genome-wide significant and/or replicable risk variants for alcohol dependence and explore their potential biological functions. METHODS: We searched in PubMed for all genome-wide association studies (GWASs) of alcohol dependence. The following three types of the results were extracted: genome-wide significant associations in an individual sample, the combined samples, or the meta-analysis (p < 5 × 10(-8) ); top-ranked associations in an individual sample (p < 10(-5) ) that were nominally replicated in other samples (p < ...
November 2014: American Journal on Addictions
#31
JOURNAL ARTICLE
Cornelia I Bargmann, Jeffrey A Lieberman
No abstract text is available yet for this article.
October 2014: American Journal of Psychiatry
#32
REVIEW
Panagiotis Ferentinos, Dimitris Dikeos
PURPOSE OF REVIEW: High comorbidity rates for various medical conditions have been documented in schizophrenia, being explained by factors either inherent to the disease or associated with antipsychotic treatment. The aim of this study is to review the genetic factors contributing to medical comorbidity in schizophrenia. RECENT FINDINGS: Based on clinical genetic studies in schizophrenia, comorbid impaired glucose tolerance/type 2 diabetes mellitus, most autoimmune disorders and cardiac autonomic dysregulation have the strongest evidence for familial predisposition...
September 2012: Current Opinion in Psychiatry
#33
REVIEW
Dragan M Svrakic, Charles F Zorumski, Nenad M Svrakic, Igor Zwir, Claude R Cloninger
PURPOSE OF REVIEW: To systematize existing data and review new findings on the cause of schizophrenia and outline an improved mixed model of schizophrenia risk. RECENT FINDINGS: Multiple and variable genetic and environmental factors interact to influence the risk of schizophrenia. Both rare variants with large effect and common variants with small effect contribute to genetic risk of schizophrenia, with no indication for differential impact on its clinical features...
March 2013: Current Opinion in Psychiatry
#34
REVIEW
Daniel J Müller, Nabilah I Chowdhury, Clement C Zai
PURPOSE OF REVIEW: Antipsychotic drugs are effective in alleviating a variety of symptoms and are medication of first choice in schizophrenia. However, a substantial interindividual variability in side effects often requires a lengthy 'trial-and-error' approach until the right medication is found for the right patient. Genetic factors have long been hypothesized to be involved and identification of related gene variants could be used to predict and tailor drug treatment. RECENT FINDINGS: This review highlighting the most recent genetic findings was conducted on the two most common and most well-studied side effects: antipsychotic-induced weight gain and tardive dyskinesia...
March 2013: Current Opinion in Psychiatry
#35
REVIEW
Ajeet B Singh, Chad A Bousman, Chee Ng, Michael Berk
PURPOSE OF REVIEW: This article reviews recent literature published over the period March 2012-August 2013 on antidepressant pharmacogenetics, with a focus on clinical translation and methodological challenges. RECENT FINDINGS: Recently, various polymorphisms associated with differential antidepressant efficacy, tolerability, and safety have emerged in association studies, but mixed findings, limited effect sizes, and poor control of confounders have prevented findings translating to practice...
January 2014: Current Opinion in Psychiatry
#36
JOURNAL ARTICLE
Jessica B Lennington, Gianfilippo Coppola, Yuko Kataoka-Sasaki, Thomas V Fernandez, Dean Palejev, Yifan Li, Anita Huttner, Mihovil Pletikos, Nenad Sestan, James F Leckman, Flora M Vaccarino
BACKGROUND: Genome-wide association studies have not revealed any risk-conferring common genetic variants in Tourette syndrome (TS), requiring the adoption of alternative approaches to investigate the pathophysiology of this disorder. METHODS: We obtained the basal ganglia transcriptome by RNA sequencing in the caudate and putamen of nine TS and nine matched normal control subjects. RESULTS: We found 309 downregulated and 822 upregulated genes in the caudate and putamen (striatum) of TS individuals...
March 1, 2016: Biological Psychiatry
#37
JOURNAL ARTICLE
Douglas F Levinson, Sara Mostafavi, Yuri Milaneschi, Margarita Rivera, Stephan Ripke, Naomi R Wray, Patrick F Sullivan
No abstract text is available yet for this article.
October 1, 2014: Biological Psychiatry
#38
REVIEW
Michael E Talkowski, Eric Vallabh Minikel, James F Gusella
The last several years have seen unprecedented advances in deciphering the genetic etiology of autism spectrum disorders (ASDs). Heritability studies have repeatedly affirmed a contribution of genetic factors to the overall disease risk. Technical breakthroughs have enabled the search for these genetic factors via genome-wide surveys of a spectrum of potential sequence variations, from common single-nucleotide polymorphisms to essentially private chromosomal abnormalities. Studies of copy-number variation have identified significant roles for both recurrent and nonrecurrent large dosage imbalances, although they have rarely revealed the individual genes responsible...
March 2014: Harvard Review of Psychiatry
#39
JOURNAL ARTICLE
Jerry Guintivano, Tori Brown, Alison Newcomer, Marcus Jones, Olivia Cox, Brion S Maher, William W Eaton, Jennifer L Payne, Holly C Wilcox, Zachary A Kaminsky
Considerable research suggests that suicide involves effects of genes, the environment, and their interaction. Analysis of three independent data sets of post-mortem brains revealed signs of increased methylation in one particular gene, SKA2, a finding that was extended to peripheral blood samples from other cohorts of prospectively followed individuals.
December 1, 2014: American Journal of Psychiatry
#40
JOURNAL ARTICLE
Dongmei Yu, Carol A Mathews, Jeremiah M Scharf, Benjamin M Neale, Lea K Davis, Eric R Gamazon, Eske M Derks, Patrick Evans, Christopher K Edlund, Jacquelyn Crane, Jesen A Fagerness, Lisa Osiecki, Patience Gallagher, Gloria Gerber, Stephen Haddad, Cornelia Illmann, Lauren M McGrath, Catherine Mayerfeld, Sampath Arepalli, Cristina Barlassina, Cathy L Barr, Laura Bellodi, Fortu Benarroch, Gabriel Bedoya Berrió, O Joseph Bienvenu, Donald W Black, Michael H Bloch, Helena Brentani, Ruth D Bruun, Cathy L Budman, Beatriz Camarena, Desmond D Campbell, Carolina Cappi, Julio C Cardona Silgado, Maria C Cavallini, Denise A Chavira, Sylvain Chouinard, Edwin H Cook, M R Cookson, Vladimir Coric, Bernadette Cullen, Daniele Cusi, Richard Delorme, Damiaan Denys, Yves Dion, Valsama Eapen, Karin Egberts, Peter Falkai, Thomas Fernandez, Eduardo Fournier, Helena Garrido, Daniel Geller, Donald L Gilbert, Simon L Girard, Hans J Grabe, Marco A Grados, Benjamin D Greenberg, Varda Gross-Tsur, Edna Grünblatt, John Hardy, Gary A Heiman, Sian M J Hemmings, Luis D Herrera, Dianne M Hezel, Pieter J Hoekstra, Joseph Jankovic, James L Kennedy, Robert A King, Anuar I Konkashbaev, Barbara Kremeyer, Roger Kurlan, Nuria Lanzagorta, Marion Leboyer, James F Leckman, Leonhard Lennertz, Chunyu Liu, Christine Lochner, Thomas L Lowe, Sara Lupoli, Fabio Macciardi, Wolfgang Maier, Paolo Manunta, Maurizio Marconi, James T McCracken, Sandra C Mesa Restrepo, Rainald Moessner, Priya Moorjani, Jubel Morgan, Heike Muller, Dennis L Murphy, Allan L Naarden, Erika Nurmi, William Cornejo Ochoa, Roel A Ophoff, Andrew J Pakstis, Michele T Pato, Carlos N Pato, John Piacentini, Christopher Pittenger, Yehuda Pollak, Scott L Rauch, Tobias Renner, Victor I Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Roxana Romero, Maria C Rosário, David Rosenberg, Stephan Ruhrmann, Chiara Sabatti, Erika Salvi, Aline S Sampaio, Jack Samuels, Paul Sandor, Susan K Service, Brooke Sheppard, Harvey S Singer, Jan H Smit, Dan J Stein, Eric Strengman, Jay A Tischfield, Maurizio Turiel, Ana V Valencia Duarte, Homero Vallada, Jeremy Veenstra-VanderWeele, Susanne Walitza, Ying Wang, Mike Weale, Robert Weiss, Jens R Wendland, Herman G M Westenberg, Yin Yao Shugart, Ana G Hounie, Euripedes C Miguel, Humberto Nicolini, Michael Wagner, Andres Ruiz-Linares, Danielle C Cath, William McMahon, Danielle Posthuma, Ben A Oostra, Gerald Nestadt, Guy A Rouleau, Shaun Purcell, Michael A Jenike, Peter Heutink, Gregory L Hanna, David V Conti, Paul D Arnold, Nelson B Freimer, S Evelyn Stewart, James A Knowles, Nancy J Cox, David L Pauls
OBJECTIVE: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex disorders remains elusive. The authors report a combined genome-wide association study (GWAS) of Tourette's syndrome and OCD. METHOD: The authors conducted a GWAS in 2,723 cases (1,310 with OCD, 834 with Tourette's syndrome, 579 with OCD plus Tourette's syndrome/chronic tics), 5,667 ancestry-matched controls, and 290 OCD parent-child trios...
January 2015: American Journal of Psychiatry
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