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RANDOMIZED CONTROLLED TRIAL
Coenraad F N Koegelenberg, Firdows Noor, Eric D Bateman, Richard N van Zyl-Smit, Axel Bruning, John A O'Brien, Clifford Smith, Mohamed S Abdool-Gaffar, Shaunagh Emanuel, Tonya M Esterhuizen, Elvis M Irusen
IMPORTANCE: Behavioral approaches and pharmacotherapy are of proven benefit in assisting smokers to quit, but it is unclear whether combining nicotine replacement therapy (NRT) with varenicline to improve abstinence is effective and safe. OBJECTIVE: To evaluate the efficacy and safety of combining varenicline and a nicotine patch vs varenicline alone in smoking cessation. DESIGN, SETTING, AND PARTICIPANTS: Randomized, blinded, placebo-controlled clinical trial with a 12-week treatment period and a further 12-week follow-up conducted in 7 centers in South Africa from April 2011 to October 2012...
July 2014: JAMA
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