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Antonio Omuro, Kathryn Beal, Philip Gutin, Sasan Karimi, Denise D Correa, Thomas J Kaley, Lisa M DeAngelis, Timothy A Chan, Igor T Gavrilovic, Craig Nolan, Adilia Hormigo, Andrew B Lassman, Ingo Mellinghoff, Christian Grommes, Anne S Reiner, Katherine S Panageas, Raymond E Baser, Viviane Tabar, Elena Pentsova, Juan Sanchez, Renata Barradas-Panchal, Jianan Zhang, Geraldine Faivre, Cameron W Brennan, Lauren E Abrey, Jason T Huse
PURPOSE: Bevacizumab is associated with decreased vascular permeability that allows for more aggressive radiotherapy schedules. We conducted a phase II trial in newly diagnosed glioblastoma utilizing a novel hypofractionated stereotactic radiotherapy (HFSRT) schedule combined with temozolomide and bevacizumab. EXPERIMENTAL DESIGN: Patients with tumor volume ≤60 cc were treated with HFSRT (6 × 6 Gy to contrast enhancement and 6 × 4 Gy to FLAIR hyperintensity with dose painting) combined with concomitant/adjuvant temozolomide and bevacizumab at standard doses...
October 1, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Patrick J Stiff, Joseph M Unger, James R Cook, Louis S Constine, Stephen Couban, Douglas A Stewart, Thomas C Shea, Pierluigi Porcu, Jane N Winter, Brad S Kahl, Thomas P Miller, Raymond R Tubbs, Deborah Marcellus, Jonathan W Friedberg, Kevin P Barton, Glenn M Mills, Michael LeBlanc, Lisa M Rimsza, Stephen J Forman, Richard I Fisher
BACKGROUND: The efficacy of autologous stem-cell transplantation during the first remission in patients with diffuse, aggressive non-Hodgkin's lymphoma classified as high-intermediate risk or high risk on the International Prognostic Index remains controversial and is untested in the rituximab era. METHODS: We treated 397 patients who had disease with an age-adjusted classification of high risk or high-intermediate risk with five cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP plus rituximab...
October 31, 2013: New England Journal of Medicine
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