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Kidney Imaging, Doppler US, Sizing and Elastography

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155 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Ulrich Jehn, Katharina Schuette-Nuetgen, Dominik Kentrup, Verena Hoerr, Stefan Reuter
To date, allogeneic kidney transplantation remains the best available therapeutic option for patients with end-stage renal disease regarding overall survival and quality of life. Despite the advancements in immunosuppressive drugs and protocols, episodes of acute allograft rejection, a sterile inflammatory process, continue to endanger allograft survival. Since effective treatment for acute rejection episodes is available, instant diagnosis of this potentially reversible graft injury is imperative. Although histological examination by invasive core needle biopsy of the graft remains the gold standard for the diagnosis of ongoing rejection, it is always associated with the risk of causing substantial graft injury as a result of the biopsy procedure itself...
2019: Contrast Media & Molecular Imaging
Philippe Braconnier, Maciej Piskunowicz, Nima Vakilzadeh, Marie-Eve Müller, Emilie Zürcher, Michel Burnier, Menno Pruijm
BACKGROUND: Renal length, volume, and parenchymal thickness are important clinical parameters, yet data concerning the accuracy and reproducibility of ultrasound (US)-based renal length and volume assessment in patients with chronic kidney disease (CKD) are scarce. PURPOSE: To establish whether renal length, volume, and parenchymal thickness can be reliably measured with renal US in patients with CKD. MATERIAL AND METHODS: All participants underwent renal US, immediately followed by 3-T magnetic resonance imaging (MRI)...
May 15, 2019: Acta Radiologica
Kai Jiang, Christopher M Ferguson, Lilach O Lerman
Renal fibrosis is a useful biomarker for diagnosis and guidance of therapeutic interventions of chronic kidney disease (CKD), a worldwide disease that affects more than 10% of the population and is one of the major causes of death. Currently, tissue biopsy is the gold standard for assessment of renal fibrosis. However, it is invasive, and prone to sampling error and observer variability, and may also result in complications. Recent advances in diagnostic imaging techniques, including magnetic resonance imaging (MRI) and ultrasonography, have shown promise for noninvasive assessment of renal fibrosis...
April 22, 2019: Translational Research: the Journal of Laboratory and Clinical Medicine
Min Fan, Xuefeng Ni, Yanjun Li, Jinsong Chen, Dongrui Cheng, Donghong Shi, Xiaozhou He, Jiqiu Wen
OBJECTIVE: To characterize capillary perfusion and tissue diffusion changes in transplant renal artery stenosis (TRAS) with diffusion-weighted imaging (DWI). MATERIALS & METHODS: We retrospectively identified 30 patients with non-contrast enhanced magnetic resonance angiography-proven TRAS. Another 20 kidney transplant recipients without TRAS were prospectively recruited to serve as control group. DWI parameters were compared among various groups with one-way analysis of variance and post hoc Tukey test...
May 6, 2019: Magnetic Resonance Imaging
Jie Mu, Yiran Mao, Fangxuan Li, Xiaojie Xin, Sheng Zhang
OBJECTIVE: Bosniak classification system provides a fine imaging evaluation for the malignant cystic renal masses. Superb microvascular imaging (SMI) is a new ultrasonic technique which apply advanced clutter suppression to reflect micro flow information. The aim of this study was to evaluate the performance of ultrasound Bosniak classification aided by SMI in diagnosis of cystic renal masses. METHODS: By comparing with CEUS and pathology, we evaluated the sensitivity, specificity and accuracy of conventional ultrasound and SMI combination in the diagnosis of renal cystic masses...
May 8, 2019: British Journal of Radiology
Hakan İmamoğlu, Gökmen Zararsız, Serap Doğan, İsmail Koçyiğit, Eray Eroğlu, Ahmet Öztürk, Nuri Erdoğan
OBJECTIVES: To evaluate the accuracy of US in calculating renal volumes and renal resistive index (RRI) that was obtained using a new method in patients with autosomal dominant polycystic kidney disease (ADPKD). METHODS: In this prospective study, US and MRI were performed in 57 patients with ADPKD (31 female and 26 male; age range, 19-79 years) between August 2017 and May 2018. The volumes determined using US and MRI were compared. The ellipsoid formula was re-evaluated using different multipliers...
April 26, 2019: European Radiology
Oriane Hanssen, Pierre Lovinfosse, Laurent Weekers, Roland Hustinx, François Jouret
Positron emission tomography combined with computed tomography (PET/CT) is a nuclear imaging technique which provides anatomical and functional information. PET/CT is increasingly used in non-oncological nephrology since conventional radiological approaches after injection of contrast agents are relatively contra-indicated in patients with chronic kidney disease (CKD). PET/CT after i.v. injection of 18 F-fluoro-deoxy-glucose (FDG) is not toxic and is characterized by a high sensitivity. The level of irradiation (∼5mSv) is acceptable...
April 11, 2019: Néphrologie & Thérapeutique
Sho Hasegawa, Etsuo A Susaki, Tetsuhiro Tanaka, Hirotaka Komaba, Takehiko Wada, Masafumi Fukagawa, Hiroki R Ueda, Masaomi Nangaku
The sympathetic nervous system is critical in maintaining the homeostasis of renal functions. However, its three-dimensional (3D) structures in the kidney have not been elucidated due to limitation of conventional imaging methods. CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis) is a newly developed tissue-clearing technique, which enables whole-organ 3D imaging without thin-sectioning. Comprehensive 3D imaging by CUBIC found that sympathetic nerves are primarily distributed around arteries in the mouse kidney...
April 4, 2019: Kidney International
Sook Sam Leong, Jeannie Hsiu Ding Wong, Mohammad Nazri Md Shah, Anushya Vijayananthan, Maisarah Jalalonmuhali, Kwan Hoong Ng
The purpose of this study was to assess the potential of shear wave elastography (SWE) as an indicator of abnormal kidney function defined by radiolabeled glomerular filtration rate (GFR). Fifty-seven patients referred for 51 Cr-ethylenediaminetetraacetic acid GFR and 99m Tc-dimercaptosuccinic acid renal scintigraphy were included. Young's modulus (YM) measured with SWE and kidney length, volume, cortical thickness and parenchymal echogenicity measured with conventional ultrasound were correlated with patients' GFR and renal scintigraphy results...
April 5, 2019: Ultrasound in Medicine & Biology
Ioannis Bellos, Despina N Perrea, Konstantinos Kontzoglou
BACKGROUND: Delayed graft function represents a major complication of kidney transplantation, leading to high rates of short and long-term morbidity. The aim of the present meta-analysis is to assess the role of renal resistive index measurement in the post-transplant period and evaluate its efficacy in the prediction of delayed graft function. METHODS: Medline, Scopus, Cochrane Central Register of Controlled Trials CENTRAL, and Google Scholar databases were systematically searched...
March 29, 2019: Transplantation Reviews
Eric M Strohm, Vaskar Gnyawali, Joseph A Sebastian, Robert Ngunjiri, Michael J Moore, Scott S H Tsai, Michael C Kolios
We describe a new technique that combines ultrasound and microfluidics to rapidly size and count cells in a high-throughput and label-free fashion. Using 3D hydrodynamic flow focusing, cells are streamed single file through an ultrasound beam where ultrasound scattering events from each individual cell are acquired. The ultrasound operates at a center frequency of 375 MHz with a wavelength of 4 μm; when the ultrasound wavelength is similar to the size of a scatterer, the power spectra of the backscattered ultrasound waves have distinct features at specific frequencies that are directly related to the cell size...
March 18, 2019: Scientific Reports
Abdullah Alabousi, Michael N Patlas, Vincent M Mellnick, Victoria Chernyak, Nataly Farshait, Douglas S Katz
There has been a substantial increase in the utilization of imaging, particularly of multi-detector computed tomography (MDCT), for the evaluation of patients with suspected urolithiasis over the past 2 decades. While the diagnostic accuracy of computed tomography (CT) for urolithiasis is excellent, it has also resulted in substantial medical expenditures and increased ionizing radiation exposure. This is especially concerning in patients with known nephrolithiasis and in younger patients. This pictorial review will focus on recent trends and controversies in imaging of patients with suspected urolithiasis, including the current roles of ultrasound (US), MDCT, and magnetic resonance imaging, the estimated radiation dose from MDCT and dose reduction strategies, as well as imaging of suspected renal colic in pregnant patients...
March 7, 2019: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
Jessica G Fried, Matthew A Morgan
Renal imaging has become a fundamental part of clinical care for patients with kidney disease. Imaging strategies for the kidney have been evolving during the past hundred years and have been even more rapidly changing during the past couple of decades due to the development of modern computed tomographic techniques, magnetic resonance imaging, and more sophisticated ultrasonographic techniques, such as contrast-enhanced ultrasonography. Applying the correct radiologic study for the clinical situation maximizes the diagnostic accuracy of the imaging, and a judicious choice between techniques helps limit radiation dose and potential adverse events...
February 15, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Shiva Asadzadeh, Hamid Tayebi Khosroshahi, Behzad Abedi, Yaghoob Ghasemi, Saeed Meshgini
BACKGROUND AND OBJECTIVE: Renal disease, such as nephritis and nephropathy, is very harmful to human health. Accordingly, how to achieve early diagnosis and enhance treatment for kidney disorders would be the important lesion. Nevertheless, the clues from the clinical data, such as biochemistry examination, serological examination, and radiological studies are quite indirect and limited. It is no doubt that pathological examination of kidney will supply the direct evidence. There is a requirement for greater understanding of image processing techniques for renal diagnosis to optimize treatment and patient care...
November 2019: Renal Failure
Niloufar Torkamani, George Jerums, Paul Crammer, Alison Skene, David A Power, Sianna Panagiotopoulos, Michele Clarke, Richard J MacIsaac, Elif I Ekinci
Mesangial metrics reflect glomerular filtration surface area in diabetes. The point-sampled intercept (PSI) method is the conventional method to calculate these parameters. However, this is time consuming and subject to underestimation. We introduce a novel three-dimensional (3D) reconstruction method applicable to light microscopy to measure mesangial metrics. Transmission electron microscopy (TEM), PSI and our new 3D imaging methods were used to quantify mesangial metrics from 22 patients with type 2 diabetes, normo-, micro- and macroalbuminuria and an estimated glomerular filtration rate of <60 mL/min/1...
February 12, 2019: Scientific Reports
T C van Smaalen, S R Ellis, N E Mascini, T Porta Siegel, B Cillero-Pastor, L M Hillen, L W E van Heurn, C J Peutz-Kootstra, R M A Heeren
The increasing analytical speed of mass-spectrometry imaging (MSI) has led to growing interest in the medical field. Acute kidney injury is a severe disease with high morbidity and mortality. No reliable cut-offs are known to estimate the severity of acute kidney injury. Thus, there is a need for new tools to rapidly and accurately assess acute ischemia, which is of clinical importance in intensive care and in kidney transplantation. We investigated the value of MSI to assess acute ischemic kidney tissue in a porcine model...
February 15, 2019: Analytical Chemistry
J H Ren, N Ma, S Y Wang, Y J Sun, Y W Zhang, W H Ma, F J Guo
Objective: To evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) and digital subtraction angiography (DSA) for renal artery stenosis (RAS). Methods: Fifty-seven hypertensive patients suspected for RAS admitted in Beijing Hospital from September 2017 to August 2018 were enrolled. All 114 renal arteries were assessed by CEUS and DSA. RAS was subdivided into low-(30%-50%), moderate-(50%-69%) and high-grade (70%-99%) subgroups. The sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) were compared between CEUS and DSA results...
January 15, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Pottumarthi V Prasad, Lu-Ping Li, Jon M Thacker, Wei Li, Bradley Hack, Orly Kohn, Stuart M Sprague
BACKGROUND: Chronic hypoxia is a well-recognized factor in the pathogenesis of chronic kidney disease (CKD). Loss of microcirculation is thought to lead to enhanced renal hypoxia, which in turn results in the development of fibrosis, a hallmark of progressive CKD. To evaluate the role of functional magnetic resonance imaging (MRI), we performed perfusion, oxygenation, and diffusion MRI measurements in individuals with diabetes and stage 3 CKD. METHODS: Fifty-four subjects (41 individuals with diabetes and stage 3 CKD and 13 healthy controls) participated in this study...
2019: American Journal of Nephrology
Ulrich Rother, Kerstin Amann, Werner Adler, Nina Nawroth, Ioannis Karampinis, Michael Keese, Serhat Manap, Susanne Regus, Alexander Meyer, Stefan Porubsky, Karl Hilgers, Bernhard K Krämer, Werner Lang, Kai Nowak, Andreas L H Gerken
OBJECTIVE: Indocyanine green fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. METHODS: Seventy-seven patients with end stage renal disease undergoing kidney transplantation were prospectively included in two centers...
January 17, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Hira Lal, Ezaz Mohamed, Neelam Soni, Priyank Yadav, Manoj Jain, Dharmendra Bhadauria, Anupma Kaul, Narayan Prasad, Amit Gupta, R K Sharma
Early graft dysfunction after renal transplantation manifests as acute rejection (AR) or acute tubular necrosis (ATN). Blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method of assessing tissue oxygenation, which may be useful for predicting acute allograft dysfunction. This was a prospective study involving 40 patients scheduled for renal transplantation from August 2012 to August 2014. In addition, 15 healthy donors were also enrolled in this study. All recipients underwent BOLD MR imaging (MRI) and R2* mapping 10-20 days after transplant, and additionally within 48 h of biopsy if there was any evidence of graft dysfunction...
November 2018: Indian Journal of Nephrology
2019-01-18 17:14:25
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