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AKI Biomarkers

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Hiroko Sonoda, Byung Rho Lee, Ki-Hoon Park, Deepak Nihalani, Je-Hyun Yoon, Masahiro Ikeda, Sang-Ho Kwon
Because exosomes have gained attention as a source of biomarkers, we investigated if miRNAs in exosomes (exo-miRs) can report the disease progression of organ injury. Using rat renal ischemia-reperfusion injury (IRI) as a model of acute kidney injury (AKI), we determined temporally-released exo-miRs in urine during IRI and found that these exo-miRs could reliably mirror the progression of AKI. From the longitudinal measurements of miRNA expression in kidney and urine, we found that release of exo- miRs was a regulated sorting process...
March 18, 2019: Scientific Reports
Kayeong Chun, Wookyung Chung, Ae Jin Kim, Hyunsook Kim, Han Ro, Jae Hyun Chang, Hyun Hee Lee, Ji Yong Jung
Procalcitonin (PCT) is a useful marker for the diagnosis of systemic inflammatory response syndrome. In addition, PCT is affected by renal function. However, few studies have investigated the relationship between PCT and the development of acute kidney injury (AKI). Hence, we investigated whether serum PCT levels at the time of admission were associated with the development of AKI and clinical outcomes. A total of 790 patients in whom PCT was measured on admission to the intensive care unit (ICU) were analyzed retrospectively...
March 18, 2019: Scientific Reports
Mina Radovic, Suzana Bojic, Jelena Kotur-Stevuljevic, Visnja Lezaic, Biljana Milicic, Milos Velinovic, Radmila Karan, Sanja Simic-Ogrizovic
Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) frequently occurs in patients assessed as low-risk for developing CSA-AKI. Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney Injury Molecule-1 (KIM-1) and lactate are promising biomarkers of CSA-AKI but have not yet been explored in low-risk patients. Aim: To evaluate urinary NGAL (uNGAL), KIM-1 and lactate as biomarkers of CSA-AKI in patients with low-risk for developing CSA-AKI. Methods: This prospective, observational study included 100 adult elective cardiac surgery patients assessed as low-risk for developing CSA-AKI...
April 2019: Journal of Medical Biochemistry
Vivek Kasinath, Osman Arif Yilmam, Mayuko Uehara, Merve Yonar, Liwei Jiang, Xiaofei Li, Weiliang Qiu, Siawosh Eskandari, Takaharu Ichimura, Reza Abdi
Ischemia-reperfusion injury represents one of the most common causes of acute kidney injury, a serious and often deadly condition that affects up to 20% of all hospitalized patients in the United States. However, the current standard assay used universally for the diagnosis of acute kidney injury-serum creatinine-does not detect renal damage early in its course. Serendipitously, we found that the immunofluorescent signal of the constitutive podocyte marker podoplanin fades in the glomerulus and intensifies in the tubulointerstitial compartment of the kidney, shortly following ischemia-reperfusion injury in 8-10 week-old male C57Bl/6j mice...
March 13, 2019: American Journal of Physiology. Renal Physiology
Shijian Feng, Lan Zhou, Duo Lin, Jianhua Zhao, Qiunong Guan, Boyuan Zheng, Kunjie Wang, Hong Li, Rong Chen, Haishan Zeng, Caigan Du
BACKGROUND: Individuals who have kidney disease or kidney transplants need routine assessment of their kidney damage and function, which are largely measured based on histological examination of kidney biopsies, blood test, and urinalysis. These methods are practically difficult or inconvenient, and expensive. The objective of this study was to develop a model to estimate the kidney damage and function by surface-enhanced Raman spectroscopy (SERS). METHODS: Urine samples were collected from two previous studies: renal allograft recipient Lewis rats receiving anti-TGF-β antibody or control antibody treatment and obese diabetic ZSF1 rats with kidney disease fed with whole grape powder-containing chow or control chow...
March 4, 2019: Clinical and Experimental Nephrology
Sean P Troth, Katerina Vlasakova, Shashi Amur, Rupesh P Amin, Warren E Glaab
Acute kidney injury continues to be a common problem and there continues to be a medical need for sensitive translational biomarkers for clinical monitoring. The past decade has yielded unprecedented progress in fundamental research into novel kidney biomarker evaluation and the mechanistic understanding of kidney injury; as such, these novel biomarkers increasingly are being used in preclinical drug development and in early clinical trials of drug candidates on a case-by-case basis, as well as in medical and veterinary practice...
March 2019: Seminars in Nephrology
Takashi Shimazui, Taka-Aki Nakada, Yoshihisa Tateishi, Taku Oshima, Tuerxun Aizimu, Shigeto Oda
BACKGROUND: Exacerbated inflammatory response is considered one of the key elements of acute kidney injury (AKI). Interleukin-6 (IL-6) is an inflammatory cytokine that plays important roles in the inflammatory response and may be useful for predicting the clinical outcomes in patients with AKI. However, supporting evidence adapted to the current KDIGO criteria is lacking. METHODS: AKI patients admitted to the ICU between Jan 2011 and Dec 2015 were retrospectively screened...
March 1, 2019: BMC Nephrology
Zacharoula Nikolakopoulou, Lauren R Hector, Benedict C Creagh-Brown, Timothy W Evans, Gregory J Quinlan, Anne Burke-Gaffney
AIM: We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB). PATIENTS & METHODS: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB. RESULTS: All markers increased significantly post-CPB with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI within 7 days...
February 27, 2019: Biomarkers in Medicine
Satoshi Washino, Keiko Hosohata, Masashi Oshima, Tomohisa Okochi, Tsuzumi Konishi, Yuhki Nakamura, Kimitoshi Saito, Tomoaki Miyagawa
Background : Vanin-1 is a novel acute kidney injury (AKI) biomarker that has not been clinically investigated as a biomarker for obstructive nephropathy. This study investigated the diagnostic value of vanin-1 as a biomarker for adult obstructive nephropathy by comparing it to existing AKI biomarkers. Methods : A total of 49 patients, 21 controls, and 28 hydronephrosis (HN) cases were assessed. AKI biomarkers in bladder (BL) urine and renal pelvic (RP) urine in the HN group were compared to each BL marker in the control group...
February 19, 2019: International Journal of Molecular Sciences
Attila Magyar, Martin Wagner, Phillip Thomas, Carolin Malsch, Reinhard Schneider, Stefan Störk, Peter U Heuschmann, Rainer G Leyh, Mehmet Oezkur
Background: Acute kidney injury (AKI) is a serious complication after cardiac surgery that is associated with increased mortality and morbidity. Heme oxygenase-1 (HO-1) is an enzyme synthesized in renal tubular cells as one of the most intense responses to oxidant stress linked with protective, anti-inflammatory properties. Yet, it is unknown if serum HO-1 induction following cardiac surgical procedure involving cardiopulmonary bypass (CPB) is associated with incidence and severity of AKI...
2019: International Journal of Nephrology and Renovascular Disease
Wenji Wang, Guihua Hao, Yu Pan, Shuai Ma, Tianye Yang, Peng Shi, Qiuyu Zhu, Yingxin Xie, Shaojun Ma, Qi Zhang, Hong Ruan, Feng Ding
BACKGROUND: Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound solute, and 90-day mortality in patients with acute kidney injury. METHODS: Adults with hospital-acquired AKI (HA-AKI) were enrolled in this prospective cohort study between 2014 and 2015, according to the KDIGO creatinine criteria. The primary end point was all-cause death during follow-up...
February 14, 2019: BMC Nephrology
In O Sun, Lilach O Lerman
MicroRNAs (miRNAs) are small, noncoding single-stranded RNA oligonucleotides that modulate physiological and pathological processes by modulating target gene expression. Many miRNAs display tissue-specific expression patterns, the dysregulation of which has been associated with various disease states, including kidney disease. Mounting evidence implicates miRNAs in various biological processes, such as cell proliferation, differentiation, and cancer. Because miRNAs are relatively stable in tissue and biological fluids, particularly when carried by extracellular vesicles, changes in their levels may reflect development of human disease...
February 13, 2019: American Journal of Physiology. Renal Physiology
William R Zhang, Chirag R Parikh
The current unidimensional paradigm of kidney disease detection is incompatible with the complexity and heterogeneity of renal pathology. The diagnosis of kidney disease has largely focused on glomerular filtration, while assessment of kidney tubular health has notably been absent. Following insult, the kidney tubular cells undergo a cascade of cellular responses that result in the production and accumulation of low-molecular-weight proteins in the urine and systemic circulation. Modern advancements in molecular analysis and proteomics have allowed the identification and quantification of these proteins as biomarkers for assessing and characterizing kidney diseases...
February 10, 2019: Annual Review of Physiology
Patrick M Honore, Leonel Barreto Gutierrez, Herbert D Spapen
No abstract text is available yet for this article.
February 2019: Critical Care Medicine
Benjamin R Griffin, Katja M Gist, Sarah Faubel
Acute kidney injury (AKI) is a common and serious medical condition associated with significant increases in morbidity, mortality, and cost of care. Because of the high incidence and poor outcomes associated with AKI, there has been significant interest in the development of new therapies for the prevention and treatment of the disease. A lack of efficacy in drug trials led to the concern that AKI was not being diagnosed early enough for an effective intervention and that a rise in serum creatinine itself is not a sensitive-enough marker...
January 17, 2019: Journal of Intensive Care Medicine
Jia-Jin Chen, Pei-Chun Fan, George Kou, Su-Wei Chang, Yi-Ting Chen, Cheng-Chia Lee, Chih-Hsiang Chang
Background: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin and compared its diagnostic performance in different AKI criteria and study populations. Method: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched PubMed, Embase, and the Cochrane database up to September 2018...
January 10, 2019: Journal of Clinical Medicine
Valentin Ion, Gwenaël Nys, Gaël Cobraiville, Etienne Cavalier, Jacques Crommen, Anne-Catherine Servais, Daniela-Lucia Muntean, Marianne Fillet
Neutrophil gelatinase associated lipocalin (NGAL) is a protein that was found to be overexpressed in acute kidney injury (AKI). The rise in NGAL concentration, both in urine or plasma, appears earlier than for other classical renal function markers such as serum creatinine, thus making it a suitable marker for early pathology detection. The aim of this study was to develop a method involving tryptic digestion, solid phase extraction and LC-MS/MS analysis to analyze NGAL in plasma medium using an isotope labeled surrogate protein, containing NGAL signature tags, as internal standard (QPrEST)...
April 1, 2019: Talanta
Reza Tavakoli, Guillaume Lebreton
No abstract text is available yet for this article.
November 2018: Journal of Thoracic Disease
Melanie Meersch, Mira Küllmar, Ronny Renfurm, Andreas Margraf, Eike Bormann, Alexander Zarbock
BACKGROUND: Acute kidney injury is a common complication after cardiac surgery, with a high impact on morbidity and mortality. Vascular adhesion protein-1 is involved in inflammation, which, in turn, is part of the development of acute kidney injury after cardiac surgery. METHODS: In this ancillary study to the RENal effects of Remote Ischemic Preconditioning in cardiac surgery trial, we investigated whether vascular adhesion protein-1 might be associated with the development of acute kidney injury in high-risk patients after cardiac surgery...
January 8, 2019: Anesthesia and Analgesia
Deborah Borfitz
Tests for AKI biomarkers would be used more widely if their role were better defined, say their proponents. Researchers are tackling the possibilities from many angles. In addition to detecting kidney injury sooner, AKI biomarkers might also be used to assess the riskiness of common kidney stressors.
November 2018: Managed Care
2019-01-10 09:51:54
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