Read by QxMD icon Read

Nephrotic syndrome

shared collection
12 papers 0 to 25 followers
By Marcel Oi Patient
Jonathan Hogan, Jai Radhakrishnan
Focal segmental glomerulosclerosis (FSGS) is the histologic end point of many disease processes that affect the kidney. Clinically, adults with FSGS present with proteinuria that may be accompanied by the nephrotic syndrome. Once identifiable (secondary) causes are excluded, the diagnosis of idiopathic FSGS, a challenging glomerular disease to understand and manage, is made. On the basis of mostly retrospective data, first-line treatment for idiopathic FSGS patients with nephrotic-range proteinuria is a prolonged course of corticosteroids...
September 2014: Advances in Chronic Kidney Disease
Lori H Dupree, Pramod Reddy
OBJECTIVE: Hypercoagulability, resulting in thromboembolic events, can be a life-threatening complication of nephrotic syndrome (NS). Conventional anticoagulants, such as warfarin, have been the standard of care for more than 50 years; however, the availability of target-specific oral anticoagulants (TSOACs) have provided additional options for the treatment and prevention of thromboembolic events. Documented use of the TSOACs in patients with NS and hypercoagulability is currently limited...
December 2014: Annals of Pharmacotherapy
J Seguier, P Guillaume-Jugnot, M Ebbo, L Daniel, N Jourde-Chiche, S Burtey, E Bernit, P Thomas, J-R Harlé, N Schleinitz
INTRODUCTION: Malignant thymoma or thymic hyperplasia is associated with various autoimmune diseases. Renal disease has rarely been reported in this condition. We report a new case with improvement of renal disease after thymectomy. CASE REPORT: A 77-year-old-women with nephritic syndrome was found to have associated thymic mass. Renal pathology showed membranous nephropathy. The thymic mass pathology showed a B2 type thymoma. After thymectomy the nephrotic syndrome improved...
July 2015: La Revue de Médecine Interne
Qingjun Pan, Jing Wu, Jingli Tao, Yanwen Chen, Lu Li, Zhenzhen Deng, Weijing Liu, Huafeng Liu
A number of studies have verified that minimal change nephrotic syndrome (MCNS) may result from the dysfunction of T cells and B cells, although the precise mechanisms are yet to be elucidated. It is widely recognized that MCNS is a T helper (Th)2-dominant glomerular disease caused by an imbalanced Th1/Th2 immune response. Increased levels of the Th2 cytokines, interleukin (IL)-4 and IL-13, have been demonstrated to be closely associated with disease activity. In addition, basophils can affect the Th1/Th2 balance by enhancing the Th2 response and impairing the Th1 response, which are then involved in the development of numerous diseases...
October 2014: Experimental and Therapeutic Medicine
Letian Zhou, Hong Liu, Fang Yuan, Shuguang Yuan
In the present study, a case of disseminated abscesses caused by Nocardia in a patient undergoing immunosuppressive therapy for nephrotic syndrome and infected with human immunodeficiency virus (HIV) is described. To the best of our knowledge, this is the first such case to be reported. The patient had membranous nephropathy and received systemic corticosteroid therapy for one year. During this time, the patient was diagnosed with HIV and developed disseminated abscesses in the lungs, brain and hip. Pathogens isolated from sputum and pus were identified as Nocardia asteroides...
October 2014: Experimental and Therapeutic Medicine
Rafael Medina-Navarro, Itzia Corona-Candelas, Saúl Barajas-González, Margarita Díaz-Flores, Genoveva Durán-Reyes
BACKGROUND: A new component of the protein antioxidant capacity, designated Response Surplus (RS), was recently described. A major feature of this component is the close relationship between protein antioxidant capacity and molecular structure. Oxidative stress is associated with renal dysfunction in patients with renal failure, and plasma albumin is the target of massive oxidation in nephrotic syndrome and diabetic nephropathy. The aim of the present study was to explore the albumin redox state and the RS component of human albumin isolated from diabetic patients with progressive renal damage...
2014: PloS One
Surya V Seshan
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease commonly affecting the kidneys, mostly mediated by immune complexes, resulting in a spectrum of glomerular lesions. They range from mesangial proliferative, focal proliferative (often segmental) with 50% of glomeruli affected, and membranous glomerulonephritis, depending on individual susceptibility, environmental triggers and the physic-chemical characteristics of the immune deposits. The clinical manifestations include varying degrees of proteinuria, hematuria, nephrotic syndrome, renal insufficiency and hypertension...
October 2014: Pathology
Kensuke Joh
A 41-year-old woman was discovered to have enteric infection of Aeromonas caviae and was treated with antibiotics. Subsequently she developed nephrotic syndrome. Renal biopsy showed a non-argentaffine hole in the glomerular basement membrane (GBM) in PAM stain with IgG and C3 deposition. This finding was similar to membranous glomerulonephritis. However, electron microscopy showed no electron dense deposits but microspheres or microtubular structures associated with podocytic infolding into the GBM. Corticosteroid treatment resulted in rapid remission...
October 2014: Pathology
Samia Barbouch, Hanene Gaied, Khaoula Ben Abdelghani, Rim Goucha, Amel Lakhal, Lamia Torjemen, Fethi Ben Hamida, Ezzedine Abderrahim, Hedi Ben Maiz, Khedher Adel
Disturbed kidney function is a common complication after bone marrow transplantation. Recently, attention has been given to immune-mediated glomerular damage related to graft versus host disease (GVHD). We describe a 19-year-old woman who developed membranous glomerulonephritis after bone marrow transplantation (BMT). Six months later, she developed soft palate, skin and liver lesions considered to be chronic GVHD. Fifteen months after undergoing BMT, this patient presented with nephrotic syndrome. A renal biopsy showed membranous glomerulonephritis associated with a focal segmental glomerulosclerosis...
September 2014: Saudi Journal of Kidney Diseases and Transplantation
Besma Ben Dhaou, Fatma Boussema, Zohra Aydi, Sonia Ketari, Lilia Baili, Fatma Ben Moussa, Lilia Rokbani
Renal paraneoplastic vasculitis (RNPV) is rare. It can be revealed by glomerulonephritis, microaneurysms or renal failure. RPNV may precede the onset of the primary tumor, and treatment and prognosis depend on the etiology (primary tumor). A 54-year-old man who had a primary lung adenocarcinoma was admitted for nephrotic syndrome. The investigations revealed RNPV. The patient was treated with corticosteroids at high dose and cyclophosphamide with improvement of the renal condition; however, the patient died from worsening of his pulmonary neoplasia...
September 2014: Saudi Journal of Kidney Diseases and Transplantation
Taiwo A Ladapo, Christopher I Esezobor, Foluso E Lesi
Insufficient data to guide the authorities responsible for resource allocation and a focus on communicable diseases increase the challenges of care of children with kidney disease in resource-constrained settings like ours. This study was performed with the aim to describe the current spectrum of pediatric nephrology disease in a tertiary hospital in Sub-Saharan Africa and highlight the challenges encountered in their care. A 4-year retrospective review of pediatric renal admissions was carried out and the overall prevalence, disease-specific prevalence and mortality rates were determined...
September 2014: Saudi Journal of Kidney Diseases and Transplantation
Radha Gajjar, Steven D Miller, Kevin E Meyers, Jill P Ginsberg
Cyclophosphamide continues to have an important role in the treatment of renal disease, including nephrotic syndrome and lupus nephritis, despite known complications of gonadotoxicity and potential infertility in both male and female patients. It is important that the physician recommending this therapy mitigates the effect of the drug on fertility by adhering to recommendations on dosing limits and offering fertility-preserving strategies. In addition to well-established methods, such as sperm banking and embryo cryopreservation, advances in reproductive technology have yielded strategies such as oocyte cryopreservation, resulting in more fertility-preserving options for the pediatric patient...
July 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"