Sanjit S Jolly, John A Cairns, Salim Yusuf, Brandi Meeks, Peggy Gao, Robert G Hart, Sasko Kedev, Goran Stankovic, Raul Moreno, David Horak, Saleem Kassam, Michael J Rokoss, Raymond C M Leung, Magdi El-Omar, Hannu O Romppanen, Ashraf Alazzoni, Aiman Alak, Anthony Fung, Dimitrios Alexopoulos, John D Schwalm, Nicholas Valettas, Vladimír Džavík
AIMS: TOTAL (N = 10 732), a randomized trial of routine manual thrombectomy vs. percutaneous coronary intervention alone in ST elevation myocardial infarction, showed no difference in the primary efficacy outcome but a significant increase in stroke. We sought to understand these findings. METHODS AND RESULTS: A detailed analysis of stroke timing, stroke severity, and stroke subtype was performed. Strokes were adjudicated by neurologists blinded to treatment assignment...
September 14, 2015: European Heart Journal