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By David Bennett Pediatric Orthopaedic Surgeon in the United States
D Doughty
The proper application of antiseptics to the open wound is controversial. With the goal of creating an optimal environment for wound repair, consideration of a topical antiseptic includes both its bactericidal activity and its potential cytotoxicity when applied to the healing wound in varying concentrations. This discussion reviews the events of wound healing, including the key cells that mediate this process, the significance of bacteria in the wound bed, and the impact of infection. Specific antiseptics, including povidone-iodine, hydrogen peroxide, acetic acid, and Dakin's solution are reviewed, emphasizing their bactericidal potential and their cytotoxic properties...
November 1994: Journal of Wound, Ostomy, and Continence Nursing
P J McKenna, G S Lehr, P Leist, R E Welling
The efficacy of topical antiseptic therapy for wounds and skin ulcers has been shown to be at the expense of fibroblast and leukocyte function and, in general, wound healing. Specifically, continued fibroblast function after exposure to antiseptics has been correlated to the concentration of the antiseptic. At concentrations that preserve fibroblast function, 0.005% sodium hypochlorite, 0.001% providone-iodine, 0.0025% acetic acid, and 0.003% hydrogen peroxide were tested for their effectiveness against various clinical isolates...
September 1991: Annals of Plastic Surgery
W Lineaweaver, S McMorris, D Soucy, R Howard
Cellular and bacterial toxicities of four commonly used topical antimicrobials (1% povidone-iodine, 3% hydrogen peroxide, 0.25% acetic acid, and 0.5% sodium hypochlorite) were assayed in vitro using cultures of human fibroblasts and Staphylococcus aureus. All agents tested at full strength killed 100 percent of exposed fibroblasts. Fibroblast toxicity exceeded bacterial toxicity with serial dilutions of hydrogen peroxide and acetic acid. Dilutions of povidone-iodine (1:1000) and sodium hypochlorite (1:100) were identified where no fibroblast toxicity occurred while full bactericidal activity persisted...
March 1985: Plastic and Reconstructive Surgery
W Lineaweaver, R Howard, D Soucy, S McMorris, J Freeman, C Crain, J Robertson, T Rumley
Three topical antibiotics and four antiseptics (1% povidone-iodine, 0.25% acetic acid, 3% hydrogen peroxide, and 0.5% sodium hypochlorite) were directly applied to cultured human fibroblasts to quantitatively assess their cytotoxicity. The four antiseptics were found to be cytotoxic; all of the cytotoxic agents except hydrogen peroxide were subsequently found to adversely affect wound healing in an animal model. Comparison of bactericidal and cytotoxic effects of serial dilutions of these four topical agents indicated the cellular toxicity of hydrogen peroxide and acetic acid exceeded their bactericidal potency...
March 1985: Archives of Surgery
S M Milner
No abstract text is available yet for this article.
July 4, 1992: Lancet
Mohammedaman Mama, Alemseged Abdissa, Tsegaye Sewunet
BACKGROUND: Wound infection is one of the health problems that are caused and aggravated by the invasion of pathogenic organisms. Information on local pathogens and sensitivity to antimicrobial agents, and topical agents like acetic acid is crucial for successful treatment of wounds. OBJECTIVES: To determine antimicrobial susceptibility pattern of bacterial isolates from wound infection and their sensitivity to alternative topical agents at Jimma University Specialized Hospital...
April 14, 2014: Annals of Clinical Microbiology and Antimicrobials
I Phillips, A Z Lobo, R Fernandes, N S Gundara
No abstract text is available yet for this article.
January 6, 1968: Lancet
David A Back, Catharina Scheuermann-Poley, Christian Willy
Infections of contaminated or colonised acute or chronic wounds remain a grave risk for patients even today. Despite modern surgical debridement concepts and antibiotics, a great need exists for new therapies in wound management. Since the late 1990s, advantageous effects of negative pressure wound therapy (NPWT) have been combined with local antiseptic wound cleansing in the development of NPWT with instillation (NPWTi). This article summarises the current scientific knowledge on this topic. MEDLINE literature searches were performed on the subject of negative pressure wound and instillation therapy covering publications from the years 1990 to 2013 (36 peer-reviewed citations) and regarding randomised controlled trials (RCTs) covering wound care with bone involvement (27 publications) or soft-tissue wounds without bone participation (11 publications) from 2005 to 2012...
December 2013: International Wound Journal
N M Williams, S Wales, G L Carlson
A case of recurrent catheter exit site infection with Pseudomonas aeruginosa is presented in a patient receiving home parenteral nutrition. The past episodes were managed by elective catheter replacement following extrusion of the catheter cuff. We describe the successful use of acetic acid to the exit site which resulted in the eradication of the organism and complete resolution of all signs.
December 1993: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
A P Fraise, M A C Wilkinson, C R Bradley, B Oppenheim, N Moiemen
Acetic acid has been shown to have good antibacterial activity against micro-organisms such as Pseudomonas aeruginosa. This study examined the activity against a range of bacterial pathogens and also assessed any reduction in antibacterial activity due to evaporation or inactivation by organic material in dressings. Acetic acid was active at dilutions as low as 0.166% and the activity was not reduced by evaporation nor by inactivation by cotton swabs. Burn injuries are a major problem in countries with limited resources...
August 2013: Journal of Hospital Infection
Henning Ryssel, Emre Gazyakan, G√ľnter Germann, Susanne Hellmich, Katrin Riedel, Matthias A Reichenberger, Christian A Radu
Bacterial colonization and infection are still the major causes of delayed healing and graft rejection following burns and they are furthermore the basis for second and third hit sepsis. Topical treatment is necessary to reduce the incidence of burn wound infection. Silver sulphadiazine (SD-Ag) is a frequently used microbicidal agent. However, this treatment causes adverse reactions and side-effects. Additionally, in recent years multiresistant bacteria, which have not been treated sufficiently, are on the rise...
September 2010: Wound Repair and Regeneration
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