Paul D Brown, Vinai Gondi, Stephanie Pugh, Wolfgang A Tome, Jeffrey S Wefel, Terri S Armstrong, Joseph A Bovi, Cliff Robinson, Andre Konski, Deepak Khuntia, David Grosshans, Tammie L S Benzinger, Deborah Bruner, Mark R Gilbert, David Roberge, Vijayananda Kundapur, Kiran Devisetty, Sunjay Shah, Kenneth Usuki, Bethany Marie Anderson, Baldassarre Stea, Harold Yoon, Jing Li, Nadia N Laack, Tim J Kruser, Steven J Chmura, Wenyin Shi, Snehal Deshmukh, Minesh P Mehta, Lisa A Kachnic
PURPOSE: Radiation dose to the neuroregenerative zone of the hippocampus has been found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity-modulated radiotherapy during whole-brain radiotherapy (WBRT) is hypothesized to preserve cognition. METHODS: This phase III trial enrolled adult patients with brain metastases to HA-WBRT plus memantine or WBRT plus memantine. The primary end point was time to cognitive function failure, defined as decline using the reliable change index on at least one of the cognitive tests...
April 1, 2020: Journal of Clinical Oncology