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6 papers 25 to 100 followers
By Ana Monteiro Md/phd student
Leonardo Henry Eusebi, Stefano Rabitti, Maria Laura Artesiani, Dania Gelli, Marco Montagnani, Rocco Maurizio Zagari, Franco Bazzoli
Proton pump inhibitors are among the most commonly prescribed classes of drugs, and their use is increasing, in particular for long-term treatment, often being over-prescribed and used for inappropriate conditions. In recent years, considerable attention has been directed towards a wide range of adverse effects, and even when a potential underlying biological mechanism is plausible, the clinical evidence of the adverse effect is often weak. Several long-term side effects have been investigated ranging from interaction with other drugs, increased risk of infection, reduced intestinal absorption of vitamins and minerals, and more recently kidney damage and dementia...
July 2017: Journal of Gastroenterology and Hepatology
Rana R McKay, Gustavo E Rodriguez, Xun Lin, Marina D Kaymakcalan, Ole-Petter R Hamnvik, Venkata S Sabbisetti, Rupal S Bhatt, Ronit Simantov, Toni K Choueiri
PURPOSE: The renin-angiotensin system may play a role in carcinogenesis. The purpose of this study was to evaluate the impact of angiotensin system inhibitors (ASI) on outcomes in metastatic renal cell carcinoma (mRCC) patients treated in the targeted therapy era. EXPERIMENTAL DESIGN: We conducted a pooled analysis of mRCC patients treated on phase II and III clinical trials. Statistical analyses were performed using Cox regression adjusted for several risk factors and the Kaplan-Meier method...
June 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Kieran McCafferty, Conor Byrne, Muhammad M Yaqoob
Over the last quarter of a century, a huge effort has been made to develop interventions that can minimise ischaemia reperfusion injury. The most potent of these are the ischaemic conditioning strategies, which comprise ischaemic preconditioning, remote ischaemic preconditioning and ischaemic postconditioning. While much of the focus for these interventions has been on protecting the myocardium, other organs including the kidney can be similarly protected. However, translation of these beneficial effects from animal models into routine clinical practice has been less straightforward than expected...
October 2014: Nephrology, Dialysis, Transplantation
Gearoid M McMahon, Sushrut S Waikar
No abstract text is available yet for this article.
July 2013: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Christopher J Cooper, Timothy P Murphy, Donald E Cutlip, Kenneth Jamerson, William Henrich, Diane M Reid, David J Cohen, Alan H Matsumoto, Michael Steffes, Michael R Jaff, Martin R Prince, Eldrin F Lewis, Katherine R Tuttle, Joseph I Shapiro, John H Rundback, Joseph M Massaro, Ralph B D'Agostino, Lance D Dworkin
BACKGROUND: Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the usefulness of stenting for the prevention of major adverse renal and cardiovascular events is uncertain. METHODS: We randomly assigned 947 participants who had atherosclerotic renal-artery stenosis and either systolic hypertension while taking two or more antihypertensive drugs or chronic kidney disease to medical therapy plus renal-artery stenting or medical therapy alone...
January 2, 2014: New England Journal of Medicine
Howard A Fink, Timothy J Wilt, Keith E Eidman, Pranav S Garimella, Roderick MacDonald, Indulis R Rutks, Michelle Brasure, Robert L Kane, Jeannine Ouellette, Manoj Monga
BACKGROUND: Optimum management to prevent recurrent kidney stones is uncertain. PURPOSE: To evaluate the benefits and harms of interventions to prevent recurrent kidney stones. DATA SOURCES: MEDLINE, Cochrane, and other databases through September 2012 and reference lists of systematic reviews and randomized, controlled trials (RCTs). STUDY SELECTION: 28 English-language RCTs that studied treatments to prevent recurrent kidney stones and reported stone outcomes...
April 2, 2013: Annals of Internal Medicine
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