collection
https://read.qxmd.com/read/34623891/disparities-in-treatment-with-direct-acting-hepatitis-c-virus-antivirals-persist-among-adults-coinfected-with-hiv-and-hepatitis-c-virus-in-us-clinics-2010-2018
#1
JOURNAL ARTICLE
Gina M Simoncini, Qingjiang Hou, Kimberly Carlson, Kate Buchacz, Ellen Tedaldi, Frank Palella, Marcus Durham, Jun Li
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection carries substantial risk for all-cause mortality and liver-related morbidity and mortality, yet many persons coinfected with HIV/HCV remain untreated for HCV. We explored demographic, clinical, and sociodemographic factors among participants in routine HIV care associated with prescription of direct-acting antivirals (DAAs). The HIV Outpatient Study (HOPS) is an ongoing longitudinal cohort study of persons with HIV in care at participating clinics since 1993...
October 2021: AIDS Patient Care and STDs
https://read.qxmd.com/read/33901017/statin-effect-on-coronary-calcium-distribution-mass-and-volume-scores-and-associations-with-immune-activation-among-hiv-persons-on-antiretroviral-therapy
#2
RANDOMIZED CONTROLLED TRIAL
Jerry Lipinski, Seunghee Margevicius, Mark D Schluchter, David L Wilson, Grace A McComsey, Chris T Longenecker
BACKGROUND: Inflammation has been associated with whole heart coronary artery calcification (CAC) among people with HIV (PWH) on antiretroviral therapy (ART); however, prior studies have not evaluated the distribution of calcium or separated mass versus volume scores, which are differentially associated with clinical events in the general population. Statins may also have a greater effect on CAC mass compared with volume. METHODS: 147 PWH were randomized 1:1 to rosuvastatin 10 mg or placebo and followed for 96 weeks...
2020: Antiviral Therapy
https://read.qxmd.com/read/34307726/forgiveness-of-dolutegravir-based-triple-therapy-compared-with-older-antiretroviral-regimens-a-prospective-multicenter-cohort-of-adherence-patterns-and-hiv-rna-replication
#3
JOURNAL ARTICLE
Jean-Jacques Parienti, Anna L Fournier, Laurent Cotte, Marie-Paule Schneider, Manuel Etienne, Guillemette Unal, Philippe Perré, Jean-Jacques Dutheil, Elodie Morilland-Lecoq, Fabien Chaillot, David R Bangsberg, Amandine Gagneux-Brunon, Thierry Prazuck, Matthias Cavassini, Renaud Verdon, Laurent Hocqueloux
BACKGROUND: For many people with HIV (PWH), taking antiretroviral therapy (ARV) every day is difficult. METHODS: Average adherence (Av-Adh) and log-transformed treatment interruption (TI) to ARV were prospectively measured over 6 months using electronic drug monitoring (EDM) in several cohorts of PWH. Multivariate linear regression models including baseline confounders explored the influence of EDM-defined adherence ( R 2 ) on 6-month log10 HIV-RNA. Multivariate logistic regression models were used to compare the risk of HIV-RNA detection (VR) within subgroups stratified by lower (≤95%) and higher (>95%) Av-Adh...
July 2021: Open Forum Infectious Diseases
https://read.qxmd.com/read/33662266/prioritising-pleasure-and-correcting-misinformation-in-the-era-of-u-u
#4
REVIEW
Sarah K Calabrese, Kenneth H Mayer, Julia L Marcus
There is widespread unawareness and disbelief regarding the evidence-based conclusion that people who have a sustained undetectable HIV viral load cannot sexually transmit HIV-ie, undetectable=untransmittable (U=U). Long-standing, misguided fear about HIV transmission persists; consequently, so does the policing of sexual expression and the penalisation of pleasure faced by people with HIV. Many people with HIV with an undetectable viral load have unnecessarily abstained from condomless sex, avoided serodifferent partnering, and had anxiety about onward sexual transmission due to perceived HIV risk that is now known to be non-existent...
March 2021: Lancet HIV
https://read.qxmd.com/read/33756512/broadly-neutralizing-hiv-1-antibody-reactivity-in-hiv-tests-implications-for-diagnostics
#5
JOURNAL ARTICLE
Tara Smith, Silvina Masciotra, Wei Luo, Vickie Sullivan, William M Switzer, Jeffrey A Johnson, Walid Heneine
OBJECTIVE: Passive immunization with broadly neutralizing antibodies (bNAbs) is under evaluation for HIV prevention. BNAbs target gp120 or gp41, two HIV envelope antigens commonly present in diagnostic tests. Depending on bNAb type and dose administered to humans, serum levels can reach ∼1 mg/mL and wane over several weeks to months. We investigated the reactivity of bNAbs in HIV serological tests to inform diagnostic testing practices for persons treated with these products. DESIGN METHODS: The anti-gp120 bNAbs VRCO1, PGT121, PGT145, 3BNC117, 10-1074, and N6 and anti-gp41 bNAbs 10E8 and 10E8v4 were tested with the laboratory-based Bio-Rad Ag/Ab Combo assay, the point-of-care single-use Determine Combo, OraQuick, Reveal G4, SureCheck, Uni-Gold, INSTI and DPP HIV 1/2 assays, and the supplemental Geenius and HIV-1 Western blot assays...
March 22, 2021: AIDS
https://read.qxmd.com/read/33705355/effect-of-vitamin-d-3-and-calcium-carbonate-supplementation-on-muscle-strength-in-postmenopausal-women-living-with-hiv
#6
JOURNAL ARTICLE
Michael T Yin, Mariana Bucovsky, John Williams, Danielle Brunjes, Arindam RoyChoudhury, Ivelisse Colon, David C Ferris, Susan Olender, P Christian Schulze, Anjali Sharma, Cosmina Zeana, Barry Zingman, Elizabeth Shane
BACKGROUND: Both falls and fractures are increased in older persons living with HIV (PLWH). Low serum total 25-hydroxyvitamin D (25-OHD) levels have been associated with falls, fractures and poor muscle strength. We hypothesized that vitamin D (VitD) supplementation would improve muscle strength in postmenopausal PLWH. METHODS: In a 12-month prospective, randomized, double-blind, study of 69 African American and Hispanic postmenopausal PLWH on antiretroviral therapy with 25-OHD ≥10 ng/ml and ≤32 ng/ml, we investigated the effects of daily low (1,000 IU; n=31) and moderate (3,000 IU; n=38) cholecalciferol doses on lean mass and strength...
2020: Antiviral Therapy
https://read.qxmd.com/read/33675622/predictive-value-of-time-space-clusters-for-hiv-transmission-in-washington-state-2017-2019
#7
JOURNAL ARTICLE
Steven J Erly, Kelly Naismith, Roxanne Kerani, Susan E Buskin, Jennifer R Reuer
BACKGROUND: Pillar 4 of the United States' End the HIV Epidemic plan is to respond quickly to HIV outbreaks, but the utility of CDC's tool for identifying HIV outbreaks via time-space cluster detection has not been evaluated. The objective of this evaluation is to quantify the ability of the CDC time-space cluster criterion to predict future HIV diagnoses and to compare it to a space-time permutation statistic implemented in SaTScan software. SETTING: Washington state from 2017 to 2019...
February 24, 2021: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/33734099/a-randomized-trial-of-a-brief-behavioral-intervention-for-prep-uptake-among-men-who-have-sex-with-men-at-increased-risk-for-hiv-infection
#8
RANDOMIZED CONTROLLED TRIAL
Philip A Chan, Amy Nunn, Jacob J van den Berg, Kevin Cormier, Genoviva Sowemimo-Coker, Siena C Napoleon, Trisha Arnold, Ethan Moitra
BACKGROUND: The aim of this study was to evaluate the efficacy of a novel, brief 2-session behavioral intervention to promote HIV pre-exposure prophylaxis (PrEP) uptake among men who have sex with men (MSM) who are behaviorally at risk for HIV. SETTING: A pilot randomized controlled trial was conducted at a sexually transmitted infection (STI) clinic to compare a brief motivational interviewing intervention with passive referral only for PrEP uptake. METHODS: MSM who scored as "high risk" on the HIV Incidence Risk index for MSM was offered a brief (15-20 minutes) motivational interviewing-based intervention at the time of STI testing to address barriers to PrEP uptake, including low risk perception, stigma, side effects, and cost...
July 1, 2021: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/33529489/effectiveness-and-safety-of-dolutegravir-two-drug-regimens-in-virologically-suppressed-people-living-with-hiv-a-systematic-literature-review-and-meta-analysis-of-real-world-evidence
#9
JOURNAL ARTICLE
Y S Punekar, D Parks, M Joshi, S Kaur, L Evitt, V Chounta, M Radford, D Jha, S Ferrante, S Sharma, J Van Wyk, A de Ruiter
OBJECTIVES: Dolutegravir (DTG) is widely recommended within three-drug regimens. However, similar efficacy and tolerability have also been achieved with DTG within two-drug regimens in clinical trials. This study evaluated the real-world effectiveness and discontinuations in people living with HIV-1 (PLHIV) switching to DTG with lamivudine (3TC) or rilpivirine (RPV). METHODS: This was a one-arm meta-analysis utilizing data from a systematic literature review. Data from real-world evidence studies of DTG + RPV and DTG + 3TC were extracted, pooled and analysed...
February 2, 2021: HIV Medicine
https://read.qxmd.com/read/33571048/not-recommended-but-done-breastfeeding-with-hiv-in-germany
#10
JOURNAL ARTICLE
Lila Haberl, Franz Audebert, Cornelia Feiterna-Sperling, Daniel Gillor, Peter Jakubowski, Celia Jonsson-Oldenbüttel, Pavel Khaykin, Rita Kiener, Anke Reitter, Ansgar Rieke, Elena Rodríguez, Steve Rößler, Jörg-Andres Rump, Gundolf Schüttfort, Christoph Stephan, Albrecht Ulmer, Amrei von Braun, Katharina von Weizsäcker, Annette Haberl
Breastfeeding (BF) in mothers living with HIV (MLWH) is still discussed controversially in resource-rich settings. In Germany, where formula feeding is recommended for MLWH single BF cases have been reported, but no systematic data collection and analysis are available so far. This study, titled HELENE, aims to fill this data gap. A questionnaire covering the course of BF was distributed by a graduate student visiting each study site. Information was collected from patient files and by personal communication with the health care provider...
February 2021: AIDS Patient Care and STDs
https://read.qxmd.com/read/33207216/evolution-and-diversity-of-immune-responses-during-acute-hiv-infection
#11
REVIEW
Samuel W Kazer, Bruce D Walker, Alex K Shalek
Understanding the earliest immune responses following HIV infection is critical to inform future vaccines and therapeutics. Here, we review recent prospective human studies in at-risk populations that have provided insight into immune responses during acute infection, including additional relevant data from non-human primate (NHP) studies. We discuss the timing, nature, and function of the diverse immune responses induced, the onset of immune dysfunction, and the effects of early anti-retroviral therapy administration...
November 17, 2020: Immunity
https://read.qxmd.com/read/33587448/risk-of-adverse-coronavirus-disease-2019-outcomes-for-people-living-with-hiv
#12
REVIEW
Maya M Mellor, Anne C Bast, Nicholas R Jones, Nia W Roberts, José M Ordóñez-Mena, Alastair J M Reith, Christopher C Butler, Philippa C Matthews, Jienchi Dorward
OBJECTIVE: To assess whether people living with HIV (PLWH) are at increased risk of coronavirus disease 2019 (COVID-19) mortality or adverse outcomes, and whether antiretroviral therapy (ART) influences this risk. DESIGN: Rapid review with meta-analysis and narrative synthesis. METHODS: We searched databases including Embase, Medline, medRxiv and Google Scholar up to 26 August 2020 for studies describing COVID-19 outcomes in PLWH and conducted a meta-analysis of higher quality studies...
March 15, 2021: AIDS
https://read.qxmd.com/read/33400687/hiv-specific-t-cell-responses-reflect-substantive-in-vivo-interactions-with-antigen-despite-long-term-therapy
#13
JOURNAL ARTICLE
Eva M Stevenson, Adam R Ward, Ronald Truong, Allison S Thomas, Szu-Han Huang, Thomas R Dilling, Sandra Terry, John K Bui, Talia M Mota, Ali Danesh, Guinevere Q Lee, Andrea Gramatica, Pragya Khadka, Winiffer D Conce Alberto, Rajesh T Gandhi, Deborah K McMahon, Christina M Lalama, Ronald J Bosch, Bernard Macatangay, Joshua C Cyktor, Joseph J Eron, John W Mellors, R Brad Jones
Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is interrupted. A central tenet of our current understanding of this persistence is that infected cells are shielded from immune recognition and elimination through a lack of antigen expression from proviruses. Efforts to cure HIV infection have therefore focused on reactivating latent proviruses to enable immune-mediated clearance, but these have yet to succeed in reducing viral reservoirs...
February 8, 2021: JCI Insight
https://read.qxmd.com/read/32734438/covid-19-among-people-living-with-hiv-a-systematic-review
#14
JOURNAL ARTICLE
Hossein Mirzaei, Willi McFarland, Mohammad Karamouzian, Hamid Sharifi
This systematic review summarizes the evidence on the earliest patients with COVID-19-HIV co-infection. We searched PubMed, Scopus, Web of Science, Embase, preprint databases, and Google Scholar from December 01, 2019, to June 1, 2020. From an initial 547 publications and 75 reports, 25 studies provided specific information on COVID-19 patients living with HIV. Studies described 252 patients, 80.9% were male, the mean age was 52.7 years, and 98% were on antiretroviral treatment (ART). Co-morbidities in addition to HIV and COVID-19 (multimorbidity) included hypertension (39...
January 2021: AIDS and Behavior
https://read.qxmd.com/read/32947592/screening-strategies-for-the-detection-of-anal-high-grade-squamous-intraepithelial-lesions-in-women-living-with-hiv
#15
JOURNAL ARTICLE
Elizabeth Y Chiao, Shelly Y Lensing, Dorothy J Wiley, Ashish A Deshmukh, Jeannette Lee, Teresa M Darragh, Mark H Einstein, Naomi Jay, John Michael Berry-Lawhorn, Joel M Palefsky, Timothy Wilkin, Luis F Barroso, Ross D Cranston, Rebecca Levine, Humberto M Guiot, Audrey L French, Deborah Citron, Masoumeh Katayoon Rezaei, Stephen E Goldstone, Elizabeth A Stier
OBJECTIVE: HIV-infected women (WLHIV) have more than 10-fold higher risk for squamous cell cancer of the anus. Experts suggest cytology-based strategies developed for cervical cancer screening may prevent anal cancer by detecting anal cytologic or histological high-grade squamous intraepithelial lesion (hHSIL) for treatment. Currently, there is no consensus on anal-hHSIL screening strategies for WLHIV. DESIGN: Between 2014 and 2016, 276 WLHIV were recruited at 12 US AIDS Malignancy Consortium clinical trials sites to evaluate hHSIL prevalence and (test) screening strategies...
December 1, 2020: AIDS
https://read.qxmd.com/read/30785191/persistent-low-level-viremia-while-on-antiretroviral-therapy-is-an-independent-risk-factor-for-virologic-failure
#16
MULTICENTER STUDY
Christie Joya, Seung Hyun Won, Christina Schofield, Tahaniyat Lalani, Ryan C Maves, Karl Kronmann, Robert Deiss, Jason Okulicz, Brian K Agan, Anuradha Ganesan
BACKGROUND: Whether persistent low-level viremia (pLLV) predicts virologic failure (VF) is unclear. We used data from the US Military HIV Natural History Study (NHS), to examine the association of pLLV and VF. METHODS: NHS subjects who initiated combination antiretroviral therapy (ART) after 1996 were included if they had 2 or more VLs measured with a lower limit of detection of ≤50 copies/mL. VF was defined as a confirmed VL ≥200 copies/mL or any VL >1000 copies/mL...
November 27, 2019: Clinical Infectious Diseases
https://read.qxmd.com/read/32947593/elevated-il-13-in-effusions-of-patients-with-hiv-and-primary-effusion-lymphoma-as-compared-with-other-kshv-associated-disorders
#17
JOURNAL ARTICLE
Ramya Ramaswami, Kathryn Lurain, Vickie Ann Marshall, Adam Rupert, Nazzarena Labo, Elena Cornejo-Castro, Wendell Miley, Hao-Wei Wang, Anaida Widell, Matthew Lindsley, Constance Yuan, Maryalice Stetler-Stevenson, Armando C Filie, Denise Whitby, Joseph Ziegelbauer, Thomas S Uldrick, Robert Yarchoan
OBJECTIVE: To assess the cytokine and viral profiles of effusions and peripheral blood among patients diagnosed with HIV and Kaposi sarcoma herpesvirus (KSHV, also known as human herpesvirus 8 [HHV-8]) associated conditions. DESIGN: Retrospective comparative study evaluating clinicopathologic findings in patients with HIV and KSHV-associated conditions presenting with an effusion between 2010-2018. METHODS: Paired peripheral blood and effusion samples collected at the time of pathological diagnosis of KSHV-associated conditions (Kaposi sarcoma (KS), KSHV-associated multicentric Castleman disease (KSHV-MCD), primary effusion lymphoma (PEL), or KSHV-associated inflammatory cytokine syndrome (KICS)) were evaluated for disease-specific and compartment-specific (effusion versus blood) characteristics...
September 17, 2020: AIDS
https://read.qxmd.com/read/32955927/prevalence-and-association-of-perianal-and-intra-anal-warts-with-composite-high-grade-squamous-intraepithelial-lesions-among-gay-and-bisexual-men-baseline-data-from-the-study-of-the-prevention-of-anal-cancer
#18
JOURNAL ARTICLE
Sian L Goddard, David J Templeton, Kathy Petoumenos, Fengyi Jin, Richard J Hillman, Carmella Law, Jennifer M Roberts, Christopher K Fairley, Suzanne M Garland, Andrew E Grulich, Isobel Mary Poynten
Human papillomavirus (HPV) causes anal warts and anal squamous cell carcinoma (SCC). A higher incidence of anal cancer has been found among individuals previously diagnosed with anogenital warts. We aimed to investigate the association between anal warts and the presumed anal SCC precursor high-grade squamous intraepithelial lesion (HSIL), among participants in the Study of the Prevention of Anal Cancer (SPANC). SPANC was a longitudinal study of anal HPV infections and related lesions among gay and bisexual men (GBM) age 35 years and older, in Sydney, Australia...
October 2020: AIDS Patient Care and STDs
https://read.qxmd.com/read/32741089/methamphetamine-and-cardiac-disease-among-people-with-hiv-infection
#19
JOURNAL ARTICLE
Tcs Martin, S Gianella, D Franklin, P Hsue, D M Smith
OBJECTIVES: People living with HIV (PWH) are at elevated risk of cardiac disease compared to the general population. Methamphetamine use has been associated with structural heart disease and increased mortality from cardiovascular disease but has not been explored as a cause of cardiac disease among PWH. We sought to evaluate the association of methamphetamine use and cardiac disease among PWH. METHODS: We performed a case-control study of participant data in the HIV Neurobehavioral Research Program...
November 2020: HIV Medicine
https://read.qxmd.com/read/32732634/comorbidity-indices-in-people-with-hiv-and-considerations-for-coronavirus-disease-2019-outcomes
#20
JOURNAL ARTICLE
Alan Winston, Davide De Francesco, Frank Post, Marta Boffito, Jaime Vera, Ian Williams, Jane Anderson, Patrick W G Mallon, Caroline A Sabin
OBJECTIVE: To determine comorbidity indices in people with HIV (PWH) and lifestyle-similar HIV-negative controls. DESIGN: Cross-sectional analysis of the Pharmacokinetic and clinical Observations in PeoPle over fiftY cohort study in the United Kingdom and Ireland. METHODS: The Elixhauser Comorbidity Index (ECI), Charlson Comorbidity Index and the Comorbidity Burden Index were compared between older PWH and HIV-negative controls using the Mann-Whitney U test; the magnitude of the difference between groups was quantified using the r effect size...
October 1, 2020: AIDS
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