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https://read.qxmd.com/read/30602460/hiv-peptidome-wide-association-study-reveals-patient-specific-epitope-repertoires-associated-with-hiv-control
#1
Jatin Arora, Paul J McLaren, Nimisha Chaturvedi, Mary Carrington, Jacques Fellay, Tobias L Lenz
Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I molecules has repeatedly been associated with HIV-1 control and progression to AIDS, accounting for up to 12% of the variation in HIV-1 set point viral load (spVL). This suggests a key role in disease control for HLA presentation of HIV-1 epitopes to cytotoxic T cells. However, a comprehensive understanding of the relevant HLA-bound HIV epitopes is still elusive. Here we describe a peptidome-wide association study (PepWAS) approach that integrates HLA genotypes and spVL data from 6,311 HIV-infected patients to interrogate the entire HIV-1 proteome (3,252 unique peptides) for disease-relevant peptides...
January 15, 2019: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/30734998/establishing-a-hepatitis-c-continuum-of-care-among-hiv-hepatitis-c-virus-coinfected-individuals-in-eurosida
#2
S Amele, L Peters, M Sluzhynska, A Yakovlev, A Scherrer, P Domingo, J Gerstoft, J P Viard, M Gisinger, R Flisiak, S Bhaghani, M Ristola, C Leen, E Jablonowska, G Wandeler, H Stellbrink, K Falconer, A D'Arminio Monforte, A Horban, J K Rockstroh, J D Lundgren, A Mocroft
OBJECTIVES: The aim of the study was to establish a methodology for evaluating the hepatitis C continuum of care in HIV/hepatitis C virus (HCV)-coinfected individuals and to characterize the continuum in Europe on 1 January 2015, prior to widespread access to direct-acting antiviral (DAA) therapy. METHODS: Stages included in the continuum were as follows: anti-HCV antibody positive, HCV RNA tested, currently HCV RNA positive, ever HCV RNA positive, ever received HCV treatment, completed HCV treatment, follow-up HCV RNA test, and cure...
February 8, 2019: HIV Medicine
https://read.qxmd.com/read/30574873/disparate-effects-of-cytotoxic-chemotherapy-on-the-antiviral-activity-of-antiretroviral-therapy-implications-for-treatments-of-hiv-infected-cancer-patients
#3
Sandra Medina-Moreno, Juan C Zapata, Mackenzie L Cottrell, Nhut M Le, Sijia Tao, Joseph Bryant, Edward Sausville, Raymond F Schinazi, Angela Dm Kashuba, Robert R Redfield, Alonso Heredia
BACKGROUND: Cancer is a leading cause of death in HIV-infected patients in the era of combination antiretroviral therapy (cART). Yet, there are no specific guidelines for the combined use of cART and chemotherapy in HIV-infected cancer patients. The cellular enzyme thymidylate synthase (TS) catalyzes the conversion of dUMP to TMP, which is converted to TDP and ultimately to TTP, a building block in DNA synthesis. TS inhibitors are recommended in some cancers, particularly non-small cell lung cancer (NSCLC)...
December 21, 2018: Antiviral Therapy
https://read.qxmd.com/read/30487276/mechanisms-of-abrupt-loss-of-virus-control-in-a-cohort-of-previous-hiv-controllers
#4
Miriam Rosás-Umbert, Anuska Llano, Rocío Bellido, Alex Olvera, Marta Ruiz-Riol, Muntsa Rocafort, Marco A Fernández, Patricia Cobarsi, Manel Crespo, Lucy Dorrell, Jorge Del Romero, José Alcami, Roger Paredes, Christian Brander, Beatriz Mothe
Elite and Viremic HIV controllers are able to control their HIV infection and maintain undetectable or low-level viremia in the absence of antiretroviral treatment. Despite extensive studies, the immune factors responsible for such exclusive control remain poorly defined. We identified a cohort of 14 HIV controllers that suffered an abrupt loss of HIV control (LoC) to investigate possible mechanisms and virological and immunological events related to the sudden loss of control. The in-depth analysis of these subjects involved the study of cell-tropism of circulating virus, evidence for HIV super-infection, cellular immune responses to HIV as well as an examination of viral adaptation to host immunity by Gag sequencing...
November 28, 2018: Journal of Virology
https://read.qxmd.com/read/30400332/vitamin-d-nutrient-hormone-and-immunomodulator
#5
REVIEW
Francesca Sassi, Cristina Tamone, Patrizia D'Amelio
The classical functions of vitamin D are to regulate calcium-phosphorus homeostasis and control bone metabolism. However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. These observations, together with experimental studies, suggest a critical role for vitamin D in the modulation of immune function. This leads to the hypothesis of a disease-specific alteration of vitamin D metabolism and reinforces the role of vitamin D in maintaining a healthy immune system...
November 3, 2018: Nutrients
https://read.qxmd.com/read/30289884/effects-of-a-brief-video-intervention-on-treatment-initiation-and-adherence-among-patients-attending-human-immunodeficiency-virus-treatment-clinics
#6
Mary Spink Neumann, Aaron Plant, Andrew D Margolis, Craig B Borkowf, C Kevin Malotte, Cornelis A Rietmeijer, Stephen A Flores, Lydia O'Donnell, Susan Robilotto, Athi Myint-U, Jorge A Montoya, Marjan Javanbakht, Jeffrey D Klausner
BACKGROUND: Persons with human immunodeficiency virus (HIV) who get and keep a suppressed viral load are unlikely to transmit HIV. Simple, practical interventions to help achieve HIV viral suppression that are easy and inexpensive to administer in clinical settings are needed. We evaluated whether a brief video containing HIV-related health messages targeted to all patients in the waiting room improved treatment initiation, medication adherence, and retention in care. METHODS AND FINDINGS: In a quasi-experimental trial all patients (N = 2,023) attending two HIV clinics from June 2016 to March 2017 were exposed to a theory-based, 29-minute video depicting persons overcoming barriers to starting treatment, taking medication as prescribed, and keeping medical appointments...
2018: PloS One
https://read.qxmd.com/read/30344084/leave-no-one-behind-response-to-new-evidence-and-guidelines-for-the-management-of-cryptococcal-meningitis-in-low-income-and-middle-income-countries
#7
REVIEW
Angela Loyse, Jessica Burry, Jennifer Cohn, Nathan Ford, Tom Chiller, Isabela Ribeiro, Sinata Koulla-Shiro, Janneth Mghamba, Angela Ramadhani, Rose Nyirenda, Sani H Aliyu, Douglas Wilson, Thuy Le, Rita Oladele, Sokoine Lesikari, Conrad Muzoora, Newton Kalata, Elvis Temfack, Yacouba Mapoure, Victor Sini, Duncan Chanda, Meshack Shimwela, Shabir Lakhi, Jonathon Ngoma, Lilian Gondwe-Chunda, Chase Perfect, Amir Shroufi, Isabelle Andrieux-Meyer, Adrienne Chan, Charlotte Schutz, Mina Hosseinipour, Charles Van der Horst, Jeffrey D Klausner, David R Boulware, Robert Heyderman, David Lalloo, Jeremy Day, Joseph N Jarvis, Marcio Rodrigues, Shabbar Jaffar, David Denning, Chantal Migone, Megan Doherty, Olivier Lortholary, Françoise Dromer, Muirgen Stack, Síle F Molloy, Tihana Bicanic, Joep van Oosterhout, Peter Mwaba, Cecilia Kanyama, Charles Kouanfack, Sayoki Mfinanga, Nelesh Govender, Thomas S Harrison
In 2018, WHO issued guidelines for the diagnosis, prevention, and management of HIV-related cryptococcal disease. Two strategies are recommended to reduce the high mortality associated with HIV-related cryptococcal meningitis in low-income and middle-income countries (LMICs): optimised combination therapies for confirmed meningitis cases and cryptococcal antigen screening programmes for ambulatory people living with HIV who access care. WHO's preferred therapy for the treatment of HIV-related cryptococcal meningitis in LMICs is 1 week of amphotericin B plus flucytosine, and the alternative therapy is 2 weeks of fluconazole plus flucytosine...
October 18, 2018: Lancet Infectious Diseases
https://read.qxmd.com/read/30138062/hiv-preexposure-prophylaxis-initiation-at-a-large-community-clinic-differences-between-eligibility-awareness-and-uptake
#8
Chelsea L Shover, Marjan Javanbakht, Steven Shoptaw, Robert K Bolan, Sung-Jae Lee, Jeffrey T Parsons, Jonathon Rendina, Pamina M Gorbach
OBJECTIVES: To characterize uptake of HIV preexposure prophylaxis (PrEP) in a community setting and to identify disparities in PrEP use by demographic and behavioral factors associated with increased HIV risk. METHODS: We conducted a cross-sectional study of 19 587 men who have sex with men and transgender people visiting a Los Angeles, California, clinic specializing in lesbian, gay, bisexual, and transgender care between August 2015 and February 2018 by using clinical care data...
October 2018: American Journal of Public Health
https://read.qxmd.com/read/30067408/non-aids-mortality-is-higher-among-successfully-treated-people-living-with-hiv-compared-with-matched-hiv-negative-control-persons-a-15-year-follow-up-cohort-study-in-sweden
#9
Zaake de Coninck, Laith Hussain-Alkhateeb, Göran Bratt, Anna Mia Ekström, Magnus Gisslén, Max Petzold, Veronica Svedhem
There is an ongoing debate whether the life span of successfully treated people living with HIV (PLHIV) is comparable with that of the general population. The aim of this cohort study is to compare all-cause mortality between all PLHIV, successfully treated PLHIV, and HIV-negative control persons from the general population and to explore the impact of viral load (VL) at diagnosis. A total of 4066 PLHIV were matched against 8072 HIV-negative controls according to age, sex, and region of birth. Further, associations between VL at diagnosis, time on treatment, treatment outcome, and mortality were assessed over a 15-year period...
August 2018: AIDS Patient Care and STDs
https://read.qxmd.com/read/30346801/trends-in-neonatal-prophylaxis-and-predictors-of-combination-antiretroviral-prophylaxis-in-us-infants-from-1990-to-2015
#10
Paige L Williams, Yanling Huo, Richard Rutstein, Rohan Hazra, Kathryn Rough, Russell B Van Dyke, Ellen G Chadwick
Postnatal antiretroviral (ARV) prophylaxis for infants born to women with HIV is a critical component of perinatal HIV transmission prevention. However, variability in prophylaxis regimens remains and consistency with guidelines has not been evaluated in the United States. We evaluated trends over time in prophylaxis regimens among 6386 HIV-exposed uninfected (HEU) infants using pooled data spanning two decades from three US-based cohorts: the Women and Infants Transmission Study (WITS, 1990-2007), Pediatric AIDS Clinical Trials Group (PACTG) 219C (1993-2007), and the PHACS Surveillance Monitoring of ART Toxicities (SMARTT) study (2007-2015)...
February 2018: AIDS Patient Care and STDs
https://read.qxmd.com/read/30362282/shedding-light-on-iris-from-pathophysiology-to-treatment-of-cryptococcal-meningitis-and-immune-reconstitution-inflammatory-syndrome-in-hiv-infected-individuals
#11
A Balasko, Y Keynan
OBJECTIVES: The aim of this work was to review current treatment options and propose alternatives for immune reconstitution inflammatory syndrome (IRIS) in HIV-infected individuals with cryptococcal meningitis (CM) (termed 'HIV-CM IRIS'). As a consequence of the immunocompromised state of these individuals, the initial immune response to CM is predominantly type 2 T helper (Th2) /Th17 rather than Th1, leading to inefficient fungal clearance at the time of antiretroviral initiation, and a subsequent overexaggeration of the Th1 response and life-threatening IRIS development...
January 2019: HIV Medicine
https://read.qxmd.com/read/22719248/hiv-specific-antibodies-capable-of-adcc-are-common-in-breastmilk-and-are-associated-with-reduced-risk-of-transmission-in-women-with-high-viral-loads
#12
Jennifer Mabuka, Ruth Nduati, Katherine Odem-Davis, Dylan Peterson, Julie Overbaugh
There are limited data describing the functional characteristics of HIV-1 specific antibodies in breast milk (BM) and their role in breastfeeding transmission. The ability of BM antibodies to bind HIV-1 envelope, neutralize heterologous and autologous viruses and direct antibody-dependent cell cytotoxicity (ADCC) were analyzed in BM and plasma obtained soon after delivery from 10 non-transmitting and 9 transmitting women with high systemic viral loads and plasma neutralizing antibodies (NAbs). Because subtype A is the dominant subtype in this cohort, a subtype A envelope variant that was sensitive to plasma NAbs was used to assess the different antibody activities...
2012: PLoS Pathogens
https://read.qxmd.com/read/30325782/low-performance-of-ultrasound-surveillance-for-the-diagnosis-of-hepatocellular-carcinoma-in-hiv-infected-patients
#13
Nicolás Merchante, Blanca Figueruela, Miguel Rodríguez-Fernández, Francisco Rodríguez-Arrondo, Boris Revollo, Sofía Ibarra, María J Galindo, Esperanza Merino, Marta Montero, Francisco Téllez, Miguel García-Deltoro, Antonio Rivero-Juárez, Marcial Delgado-Fernández, María J Ríos-Villegas, Koldo Aguirrebengoa, María A García, Joseba Portu, Francisco J Vera-Méndez, Marina Villalobos, Carlos Mínguez, Ignacio De Los Santos, Miguel A López-Ruz, Mohamed Omar, Carlos Galera, Juan Macias, Juan A Pineda
OBJECTIVE: To assess the performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma (HCC) in HIV-infected patients. METHODS: The GEHEP-002 cohort recruits HCC cases diagnosed in HIV-infected patients from 32 centers across Spain. The proportion of 'ultrasound lack of detection', defined as HCC diagnosed within the first 3 months after a normal surveillance ultrasound, and the proportion of 'surveillance failure', defined as cases in which surveillance failed to detect HCC at early stage, were assessed...
February 1, 2019: AIDS
https://read.qxmd.com/read/30281618/prevalence-incidence-predictors-treatment-and-control-of-hypertension-among-hiv-positive-adults-on-antiretroviral-treatment-in-public-sector-treatment-programs-in-south-africa
#14
Alana T Brennan, Lise Jamieson, Nigel J Crowther, Matthew P Fox, Jaya A George, Kaitlyn M Berry, Andrew Stokes, Mhairi Maskew, Ian Sanne, Lawrence Long, Naseem Cassim, Sydney Rosen
BACKGROUND: One of the key risk factors for cardiovascular disease is hypertension. Hypertension, which leads to heart attacks and strokes, already affects one billion people worldwide, making it a global public health issue. Incidence and prevalence of the condition is on the rise in low- and middle-income countries, with the biggest increase in sub-Saharan Africa and South Africa at the forefront. We examined the prevalence, incidence, predictors, treatment, and control of hypertension among HIV-positive patients on ART in a large South African observational cohort...
2018: PloS One
https://read.qxmd.com/read/25414417/the-role-of-cell-associated-virus-in-mother-to-child-hiv-transmission
#15
REVIEW
Caitlin Milligan, Julie Overbaugh
Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) continues to contribute to the global burden of disease despite great advances in antiretroviral (ARV) treatment and prophylaxis. In this review, we discuss the proposed mechanisms of MTCT, evidence for cell-free and cell-associated transmission in different routes of MTCT, and the impact of ARVs on virus levels and transmission. Many population-based studies support a role for cell-associated virus in transmission and in vitro studies also provide some support for this mode of transmission...
December 15, 2014: Journal of Infectious Diseases
https://read.qxmd.com/read/30182478/coronary-artery-calcium-and-intima-media-thickness-are-associated-with-level-of-cytomegalovirus-immunoglobulin-g-in-hiv-infected-patients
#16
A Knudsen, U S Kristoffersen, I Panum, Y B Hansen, P D Skottrup, P Hasbak, A Kjaer, A-M Lebech
Coinfection with cytomegalovirus (CMV) may be involved in cardiovascular disease in HIV-infected patients. We found that higher level of CMV immunoglobulin G (IgG) was independently associated with an increased risk of coronary artery calcium and higher intima-media thickness in HIV-infected patients but not in healthy controls after adjustment for other cardiovascular risk factors and levels of herpes viridae IgG.
September 4, 2018: HIV Medicine
https://read.qxmd.com/read/21963941/urinary-lipoarabinomannan-as-predictor-for-the-tuberculosis-immune-reconstitution-inflammatory-syndrome
#17
Anali Conesa-Botella, Marguerite Massinga Loembé, Yukari C Manabe, William Worodria, Doreen Mazakpwe, Kenneth Luzinda, Harriet Mayanja-Kizza, Mitra Miri, Olive Mbabazi, Olivier Koole, Luc Kestens, Robert Colebunders
BACKGROUND: Upon initiation of antiretroviral therapy (ART), 15.7% [95% confidence interval (CI): 9.7% to 24.5%] of tuberculosis (TB)-HIV-coinfected individuals experience paradoxical worsening of their clinical status with exuberant inflammation consistent with immune reconstitution inflammatory syndrome (IRIS). We investigated whether a positive urinary TB lipoarabinomannan (LAM) antigen enzyme-linked immunosorbent assay test before ART initiation was associated with development of paradoxical TB-IRIS...
December 15, 2011: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://read.qxmd.com/read/29997284/hiv-infection-results-in-clonal-expansions-containing-integrations-within-pathogenesis-related-biological-pathways
#18
Kevin G Haworth, Lauren E Schefter, Zachary K Norgaard, Christina Ironside, Jennifer E Adair, Hans-Peter Kiem
The genomic integration of HIV into cells results in long-term persistence of virally infected cell populations. This integration event acts as a heritable mark that can be tracked to monitor infected cells that persist over time. Previous reports have documented clonal expansion in people and have linked them to proto-oncogenes; however, their significance or contribution to the latent reservoir has remained unclear. Here, we demonstrate that a directed pattern of clonal expansion occurs in vivo, specifically in gene pathways important for viral replication and persistence...
July 12, 2018: JCI Insight
https://read.qxmd.com/read/30157970/incidence-of-cardiovascular-diseases-in-a-nationwide-hiv-aids-patient-cohort-in-taiwan-from-2000-to-2014
#19
Yun-Ju Lai, Yu-Yen Chen, Hsin-Hui Huang, Ming-Chung Ko, Chu-Chieh Chen, Yung-Feng Yen
The purpose of the study was to determine the incidence of cardiovascular disease (CVD) among people living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (PLWHA) in Taiwan. PLWHA were identified from the Taiwan Centers for Disease Control HIV Surveillance System between 2000 and 2014. To examine the effect of active antiretroviral therapy (HAART) on CVD incidence, incidence densities and standardised incidence rates (SIRs) of CVD were calculated after stratifying PLWHA by HAART...
December 2018: Epidemiology and Infection
https://read.qxmd.com/read/30084191/acceptability-of-high-resolution-anoscopy-for-anal-cancer-screening-in-hiv-infected-patients
#20
J O Lam, G M Barnell, M Merchant, C G Ellis, M J Silverberg
OBJECTIVES: HIV-infected individuals are at increased risk of anal cancer. Screening for anal cancer precursors using high-resolution anoscopy (HRA) may be clinically beneficial. In this study, we examined patient tolerability of this procedure. METHODS: The acceptability of HRA was evaluated among HIV-infected patients who completed a first-time HRA between July 2008 and December 2013 at Kaiser Permanente Northern California. We reviewed electronic medical records to identify lack of HRA acceptability, which was defined as receipt of HRA with sedation, dispensation of opioid analgaesia, and/or an urgent care visit following HRA, and to evaluate factors associated with patients not returning for a recommended repeat HRA (proxy for HRA acceptability)...
November 2018: HIV Medicine
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