Eva M Stevenson, Adam R Ward, Ronald Truong, Allison S Thomas, Szu-Han Huang, Thomas R Dilling, Sandra Terry, John K Bui, Talia M Mota, Ali Danesh, Guinevere Q Lee, Andrea Gramatica, Pragya Khadka, Winiffer D Conce Alberto, Rajesh T Gandhi, Deborah K McMahon, Christina M Lalama, Ronald J Bosch, Bernard Macatangay, Joshua C Cyktor, Joseph J Eron, John W Mellors, R Brad Jones
Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is interrupted. A central tenet of our current understanding of this persistence is that infected cells are shielded from immune recognition and elimination through a lack of antigen expression from proviruses. Efforts to cure HIV infection have therefore focused on reactivating latent proviruses to enable immune-mediated clearance, but these have yet to succeed in reducing viral reservoirs...
February 8, 2021: JCI Insight