William V Bobo, Noreen A Reilly-Harrington, Terence A Ketter, Benjamin D Brody, Gustavo Kinrys, David E Kemp, Richard C Shelton, Susan L McElroy, Louisa G Sylvia, James H Kocsis, Melvin G McInnis, Edward S Friedman, Vivek Singh, Mauricio Tohen, Charles L Bowden, Thilo Deckersbach, Joseph R Calabrese, Michael E Thase, Andrew A Nierenberg, Dustin J Rabideau, David A Schoenfeld, Stephen V Faraone, Masoud Kamali
BACKGROUND: Little is known about the longer-term effects of adjunctive benzodiazepines on symptom response during treatment in patients with bipolar disorders. METHODS: The study sample consisted of 482 patients with bipolar I or II disorder enrolled in a 6-month, randomized, multi-site comparison of lithium- and quetiapine-based treatment. Changes in clinical measures (BISS total and subscales, CGI-BP, and CGI-Efficacy Index) were compared between participants who did and did not receive benzodiazepine treatment at baseline or during follow-up...
June 2014: Journal of Affective Disorders