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Dementia treatment

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4 papers 1000+ followers
By Frances Vickery Retired PhD state mental health inpt psychological services
James R Burrell, Glenda M Halliday, Jillian J Kril, Lars M Ittner, Jürgen Götz, Matthew C Kiernan, John R Hodges
Early reports of cognitive and behavioural deficits in motor neuron disease might have been overlooked initially, but the concept of a frontotemporal dementia-motor neuron disease continuum has emerged during the past decade. Frontotemporal dementia-motor neuron disease is now recognised as an important dementia syndrome, which presents substantial challenges for diagnosis and management. Frontotemporal dementia, motor neuron disease, and frontotemporal dementia-motor neuron disease are characterised by overlapping patterns of TAR DNA binding protein (TDP-43) pathology, while the chromosome 9 open reading frame 72 (C9orf72) repeat expansion is common across the disease spectrum...
August 27, 2016: Lancet
Chris Xu, Josephine Alexa Potter, Christopher David Carter, Clayton Miles Cooper Lang
OBJECTIVE: Tumoral calcinosis is an uncommon lesion, composed of ectopic calcified tissue, most commonly seen in the large joints of the hips, knees, shoulders, and elbows. The involvement of the hand in a healthy patient is extremely rare, and therefore this condition can cause diagnostic confusion. The purpose of this report is to describe one case of idiopathic tumoral calcinosis that occurred in the left hand of a 35-year-old healthy female patient. METHODS: The patient presented with 2-day history of acutely swelling and painful left hand middle finger metacarpal phalangeal joint without any precipitants...
2014: Eplasty
Maeve M Leonard, Meera Agar, Juliet A Spiller, Brid Davis, Mas M Mohamad, David J Meagher, Peter G Lawlor
CONTEXT: Delirium often presents difficult diagnostic and classification challenges in palliative care settings. OBJECTIVES: To review three major areas that create diagnostic and classification challenges in relation to delirium in palliative care: subsyndromal delirium (SSD), delirium in the context of comorbid dementia, and classification of psychomotor subtypes, and to identify knowledge gaps and research priorities in relation to these three areas of focus...
August 2014: Journal of Pain and Symptom Management
Laura N Gitlin, Helen C Kales, Constantine G Lyketsos
Behavioral symptoms such as repetitive speech, wandering, and sleep disturbances are a core clinical feature of Alzheimer disease and related dementias. If untreated, these behaviors can accelerate disease progression, worsen functional decline and quality of life, cause significant caregiver distress, and result in earlier nursing home placement. Systematic screening for behavioral symptoms in dementia is an important prevention strategy that facilitates early treatment of behavioral symptoms by identifying underlying causes and tailoring a treatment plan...
November 21, 2012: JAMA: the Journal of the American Medical Association
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