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O Mathiesen, J Wetterslev, V K Kontinen, H-C Pommergaard, L Nikolajsen, J Rosenberg, M S Hansen, K Hamunen, J J Kjer, J B Dahl
Post-operative pain affects millions of patients worldwide and the post-operative period has high rates of morbidity and mortality. Some of this morbidity may be related to analgesics. The aim of this review was to provide an update of current knowledge of adverse events (AE) associated with the most common perioperative non-opioid analgesics: paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids (GCCs), gabapentinoids and their combinations. The review is based on data from systematic reviews with meta-analyses of analgesic efficacy and/or adverse effects of perioperative non-opioid analgesics, and randomised trials and cohort/retrospective studies...
November 2014: Acta Anaesthesiologica Scandinavica
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