Shurjeel Uddin Qazi, Usama Qamar, Muhammad Talha Maqsood, Rabbia Gul, Saad Ali Ansari, Zeeshan Imtiaz, Amatul Noor, Mohammed Zia Khan Suheb, Zaofashan Zaheer, Adeela Andleeb, Masooma Naseem, Muhammad Shariq Akram, Mubarak Ali, Alina Barmanwalla, Rutab Tareen, Irfa Zaheer
INTRODUCTION: Endothelial dysfunction has been implicated in various cardiovascular disorders as the initial pathology. Allopurinol has been shown to improve endothelial dysfunction in patients with gout, but its effect on cardiovascular patients is unclear. AIMS: We aim to assess allopurinol efficacy in improving endothelial dysfunction overall and in different disease states including but not limited to heart failure, chronic kidney disease, ischemic heart disease METHODS: We conducted a literature search of PubMed, Cochrane's Central Library, and Scopus until December 2022, including randomized controlled trials and double-arm observational studies...
December 9, 2023: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension