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Newborn sepsis

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10 papers 0 to 25 followers
Alberto Berardi, Caterina Spada, Maria Grazia Capretti, Matilde Ciccia, Maria Rita Pulvirenti, Martina Vezzosi, Fabrizio Sandri
No abstract text is available yet for this article.
2018: Neonatology
Nidhi Chauhan, Sukirti Tiwari, Utkarsh Jain
Neonatal sepsis, a clinical disorder developed by bacterial blood stream infections (BSI) in neonates, is one of the serious global public health problems that must be addressed. More than one million of the estimated global newborn deaths per year are occurred due to severe infections. The genesis of the infection is divided into early-onset sepsis (EOS) and late-onset sepsis (LOS) of the disease. The clinical complications of neonatal sepsis may be associated with bronchopulmonary dysplasia, ductus arteriosus and necrotizing enterocolitis...
June 2017: Microbial Pathogenesis
Bereketeab Haileselassie, Erik Su, Iraklis Pozios, Teresa Fiskum, Reid Thompson, Theodore Abraham
OBJECTIVES: In the progression of severe sepsis, sepsis-induced myocardial dysfunction contributes to severity of illness and ultimate mortality. Identification of sepsis-induced myocardial dysfunction causing depressed cardiac function during critical illness has implications for ongoing patient management. However, assessing pediatric cardiac function traditionally relies on echocardiographic qualitative assessment and measurement of left ventricular ejection fraction or fractional shortening...
May 2016: Pediatric Critical Care Medicine
Patrick J M Stapleton, Madeleine Murphy, Naomi McCallion, Marion Brennan, Robert Cunney, Richard J Drew
OBJECTIVE: To establish the number of outbreaks of extended spectrum beta-lactamase (ESBL) producing organisms in neonatal intensive care units (NICUs), to determine causes, mortality rates, proportions of infants colonised and infected and the interventions that terminated outbreaks. METHODS: A systematic review of the literature in English, Spanish and French was undertaken with searches in four databases. The review conformed to the PRISMA guidelines, and the data extraction was modelled on the ORION criteria for studies of nosocomial infection...
January 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
Alonso Zea-Vera, Theresa J Ochoa
Neonatal sepsis is the third leading cause of neonatal mortality and a major public health problem, especially in developing countries. Although recent medical advances have improved neonatal care, many challenges remain in the diagnosis and management of neonatal infections. The diagnosis of neonatal sepsis is complicated by the frequent presence of noninfectious conditions that resemble sepsis, especially in preterm infants, and by the absence of optimal diagnostic tests. Since neonatal sepsis is a high-risk disease, especially in preterm infants, clinicians are compelled to empirically administer antibiotics to infants with risk factors and/or signs of suspected sepsis...
February 2015: Journal of Tropical Pediatrics
Fredrick J Bohanon, Amy A Mrazek, Mohamed T Shabana, Sarah Mims, Geetha L Radhakrishnan, George C Kramer, Ravi S Radhakrishnan
BACKGROUND: Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups. METHODS: With Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain...
October 2015: American Journal of Surgery
William E Benitz, James L Wynn, Richard A Polin
No abstract text is available yet for this article.
April 2015: Journal of Pediatrics
L Koch, A Bosk, M Sasse, P Ruef, J Poeschl
BACKGROUND: In 2002 and 2007, the American College of Critical Care Medicine (ACCCM) provided clinical guidelines for hemodynamic support of pediatric and neonatal patients in septic shock. In 2008 and 2013, the Surviving Sepsis Campaign (SSC) Guidelines Committee offered up-to-date clinical guidelines for the management of severe sepsis and septic shock in adults and in pediatric patients. The aim of this study was to assess the standard of care of neonates with severe sepsis and septic shock in German neonatal intensive care units (NICUs) with regard to variability in management and guideline conformity...
January 2015: Klinische Pädiatrie
Cassandra D Josephson, Angela M Caliendo, Kirk A Easley, Andrea Knezevic, Neeta Shenvi, Michael T Hinkes, Ravi M Patel, Christopher D Hillyer, John D Roback
IMPORTANCE: Postnatal cytomegalovirus (CMV) infection can cause serious morbidity and mortality in very low-birth-weight (VLBW) infants. The primary sources of postnatal CMV infection in this population are breast milk and blood transfusion. The current risks attributable to these vectors, as well as the efficacy of approaches to prevent CMV transmission, are poorly characterized. OBJECTIVE: To estimate the risk of postnatal CMV transmission from 2 sources: (1) transfusion of CMV-seronegative and leukoreduced blood and (2) maternal breast milk...
November 2014: JAMA Pediatrics
Gilles Duvoisin, Céline Fischer, Delphine Maucort-Boulch, Eric Giannoni
BACKGROUND: Despite a low positive predictive value, diagnostic tests such as complete blood count (CBC) and C-reactive protein (CRP) are commonly used to evaluate whether infants with risk factors for early-onset neonatal sepsis (EOS) should be treated with antibiotics. STUDY DESIGN: We investigated the impact of implementing a protocol aiming at reducing the number of diagnostic tests in infants with risk factors for EOS in order to compare the diagnostic performance of repeated clinical examination with CBC and CRP measurement...
2014: Swiss Medical Weekly
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