Cancer prevention

shared collection
247 papers 1000+ followers Articles on screening and lifestyle factors to recommend to patients.
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
C La Vecchia, E Negri, B D'Avanzo, S Franceschi
The relation between use of histamine-2-receptor (H2-receptor) antagonists and gastric cancer risk was investigated in a case-control study in northern Italy. 563 patients with newly diagnosed, histologically confirmed gastric cancer were compared with 1501 controls who did not have neoplastic or gastrointestinal disorders. 36 (6.3%) cases and 59 (3.3%) controls had used H2-receptor antagonists (cimetidine or ranitidine). The relative risk (RR) for ever-use was 1.8 (95% confidence intervals [CI] 1.2, 2.7). The increased risk was restricted to patients who had started treatment with H2-receptor antagonists within 5 years of the diagnosis of stomach cancer (RR 3...
August 11, 1990: Lancet
Teng Zeng, William A Mitch
The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amine-based pharmaceutical, has not been demonstrated under these conditions. In this work, we confirmed the production of N-nitrosodimethylamine (NDMA), a potent carcinogen, by nitrosation of ranitidine under stomach-relevant pH conditions in vitro We also evaluated the urinary NDMA excretion attributable to ingestion of clinically used ranitidine doses...
June 2016: Carcinogenesis
Krishnan Bhaskaran, Ian Douglas, Stephen Evans, Tjeerd van Staa, Liam Smeeth
OBJECTIVES: To investigate whether there is an association between use of angiotensin receptor blockers and risk of cancer. DESIGN: Cohort study of risk of cancer in people treated with angiotensin receptor blockers compared with angiotensin converting enzyme (ACE) inhibitors. Effects were explored with time updated covariates in Cox models adjusted for age, sex, body mass index (BMI), diabetes and metformin/insulin use, hypertension, heart failure, statin use, socioeconomic status, alcohol, smoking, and calendar year...
April 24, 2012: BMJ: British Medical Journal
Zosia Kmietowicz
No abstract text is available yet for this article.
October 24, 2018: BMJ: British Medical Journal
(no author information available yet)
No abstract text is available yet for this article.
April 5, 2016: Canadian Medical Association Journal: CMAJ
Helen G Coleman, Shivaram K Bhat, Liam J Murray, Damian T McManus, Orla M O'Neill, Anna T Gavin, Brian T Johnston
OBJECTIVES: Risk stratification of Barrett's esophagus (BE) patients based on clinical and endoscopic features may help to optimize surveillance practice for esophageal adenocarcinoma (EAC) development. The aim of this study was to investigate patient symptoms and endoscopic features at index endoscopy and risk of neoplastic progression in a large population-based cohort of BE patients. METHODS: A retrospective review of hospital records relating to incident BE diagnosis was conducted in a subset of patients with specialized intestinal metaplasia from the Northern Ireland BE register...
April 2014: American Journal of Gastroenterology
Michael F Vaezi, Peter J Kahrilas
No abstract text is available yet for this article.
September 2013: Gastroenterology
Katie S Nason, Promporn Paula Wichienkuer, Omar Awais, Matthew J Schuchert, James D Luketich, Robert W O'Rourke, John G Hunter, Cynthia D Morris, Blair A Jobe
HYPOTHESIS: Screening for esophageal adenocarcinoma has focused on identifying Barrett esophagus (BE) in patients with severe, long-standing symptoms of gastroesophageal reflux disease (GERD). Unfortunately, 95% of patients who develop esophageal adenocarcinoma are unaware of the presence of BE before their cancer diagnosis, which means they never had been selected for screening. One possible explanation is that no correlation exists between the severity of GERD symptoms and cancer risk...
July 2011: Archives of Surgery
F Hvid-Jensen, L Pedersen, P Funch-Jensen, A M Drewes
BACKGROUND: Proton pump inhibitors (PPI) may potentially modify and decrease the risk for development of oesophageal adenocarcinoma in Barrett's oesophagus (BO). AIM: To investigate if the intensity and adherence of PPI use among all patients with BO in Denmark affected the risk of oesophageal adenocarcinoma. METHODS: We performed a nationwide case-control study in Denmark among 9883 patients with a new diagnosis of BO. All incident oesophageal adenocarcinomas and high-grade dysplasias were identified, and risk ratios were estimated on the basis of prior use of PPIs...
May 2014: Alimentary Pharmacology & Therapeutics
Kerry B Dunbar, Rhonda F Souza, Stuart J Spechler
Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus...
June 2015: Gastroenterology Clinics of North America
Sarah E R Bailey, Obi C Ukoumunne, Elizabeth Shephard, Willie Hamilton
BACKGROUND: Although the association between raised platelet count (thrombocytosis) and cancer has been reported in primary and secondary care studies, UK GPs are unaware of it, and it is insufficiently evidenced for laboratories to identify and warn of it. This systematic review aimed to identify and collate evidence from studies that have investigated thrombocytosis as an early marker of cancer in primary care. METHODS: EMBASE (OvidSP), Medline (Ovid), Web of Science and The Cochrane Library were searched for relevant studies...
February 2017: Family Practice
Nicholas J Shaheen, Gary W Falk, Prasad G Iyer, Lauren B Gerson
Barrett's esophagus (BE) is among the most common conditions encountered by the gastroenterologist. In this document, the American College of Gastroenterology updates its guidance for the best practices in caring for these patients. These guidelines continue to endorse screening of high-risk patients for BE; however, routine screening is limited to men with reflux symptoms and multiple other risk factors. Acknowledging recent data on the low risk of malignant progression in patients with nondysplastic BE, endoscopic surveillance intervals are attenuated in this population; patients with nondysplastic BE should undergo endoscopic surveillance no more frequently than every 3-5 years...
January 2016: American Journal of Gastroenterology
Cathy Bennett, Paul Moayyedi, Douglas A Corley, John DeCaestecker, Yngve Falck-Ytter, Gary Falk, Nimish Vakil, Scott Sanders, Michael Vieth, John Inadomi, David Aldulaimi, Khek-Yu Ho, Robert Odze, Stephen J Meltzer, Eamonn Quigley, Stuart Gittens, Peter Watson, Giovanni Zaninotto, Prasad G Iyer, Leo Alexandre, Yeng Ang, James Callaghan, Rebecca Harrison, Rajvinder Singh, Pradeep Bhandari, Raf Bisschops, Bita Geramizadeh, Philip Kaye, Sheila Krishnadath, M Brian Fennerty, Hendrik Manner, Katie S Nason, Oliver Pech, Vani Konda, Krish Ragunath, Imdadur Rahman, Yvonne Romero, Richard Sampliner, Peter D Siersema, Jan Tack, Tony C K Tham, Nigel Trudgill, David S Weinberg, Jean Wang, Kenneth Wang, Jennie Y Y Wong, Stephen Attwood, Peter Malfertheiner, David MacDonald, Hugh Barr, Mark K Ferguson, Janusz Jankowski
OBJECTIVES: Barrett's esophagus (BE) is a common premalignant lesion for which surveillance is recommended. This strategy is limited by considerable variations in clinical practice. We conducted an international, multidisciplinary, systematic search and evidence-based review of BE and provided consensus recommendations for clinical use in patients with nondysplastic, indefinite, and low-grade dysplasia (LGD). METHODS: We defined the scope, proposed statements, and searched electronic databases, yielding 20,558 publications that were screened, selected online, and formed the evidence base...
May 2015: American Journal of Gastroenterology
John F Forbes, Ivana Sestak, Anthony Howell, Bernardo Bonanni, Nigel Bundred, Christelle Levy, Gunter von Minckwitz, Wolfgang Eiermann, Patrick Neven, Michael Stierer, Chris Holcombe, Robert E Coleman, Louise Jones, Ian Ellis, Jack Cuzick
BACKGROUND: Third-generation aromatase inhibitors are more effective than tamoxifen for preventing recurrence in postmenopausal women with hormone-receptor-positive invasive breast cancer. However, it is not known whether anastrozole is more effective than tamoxifen for women with hormone-receptor-positive ductal carcinoma in situ (DCIS). Here, we compare the efficacy of anastrozole with that of tamoxifen in postmenopausal women with hormone-receptor-positive DCIS. METHODS: In a double-blind, multicentre, randomised placebo-controlled trial, we recruited women who had been diagnosed with locally excised, hormone-receptor-positive DCIS...
February 27, 2016: Lancet
(no author information available yet)
No abstract text is available yet for this article.
June 1, 2016: American Family Physician
Aasma Shaukat, Thomas S Rector, Timothy R Church, Frank A Lederle, Adam S Kim, Jeffery M Rank, John I Allen
BACKGROUND & AIMS: Withdrawal times and adenoma detection rates are widely used quality indicators for screening colonoscopy. More rapid withdrawal times have been associated with undetected adenomas, which can increase risk for interval colorectal cancer. METHODS: We analyzed records of 76,810 screening colonoscopies performed between 2004 and 2009, by 51 gastroenterologists practicing in Minneapolis and St Paul, MN. Colonoscopy records were linked electronically to the state cancer registry (Minnesota Cancer Surveillance System) to identify incident interval cancers that were diagnosed within 5...
October 2015: Gastroenterology
Francesco Sardanelli, Franca Podo, Filippo Santoro, Siranoush Manoukian, Silvana Bergonzi, Giovanna Trecate, Daniele Vergnaghi, Massimo Federico, Laura Cortesi, Stefano Corcione, Sandro Morassut, Cosimo Di Maggio, Anna Cilotti, Laura Martincich, Massimo Calabrese, Chiara Zuiani, Lorenzo Preda, Bernardo Bonanni, Luca A Carbonaro, Alma Contegiacomo, Pietro Panizza, Ernesto Di Cesare, Antonella Savarese, Marcello Crecco, Daniela Turchetti, Maura Tonutti, Paolo Belli, Alessandro Del Maschio
OBJECTIVES: : To prospectively compare clinical breast examination, mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (MRI) in a multicenter surveillance of high-risk women. MATERIALS AND METHODS: : We enrolled asymptomatic women aged ≥ 25: BRCA mutation carriers; first-degree relatives of BRCA mutation carriers, and women with strong family history of breast/ovarian cancer, including those with previous personal breast cancer. RESULTS: : A total of 18 centers enrolled 501 women and performed 1592 rounds (3...
February 2011: Investigative Radiology
Elham Kharazmi, Kari Hemminki, Eero Pukkala, Kristina Sundquist, Laufey Tryggvadottir, Steinar Tretli, Jörgen H Olsen, Mahdi Fallah
BACKGROUND: None of the population-based epidemiologic studies to date has had a large enough sample size to show the familial risk of testicular cancer (TC) by age at diagnosis for patients and their relatives or for rare histologic subtypes. OBJECTIVE: To estimate absolute and relative risks of TC in relatives of TC patients by age at diagnosis in patients and their relatives and histological subtypes. DESIGN, SETTING, AND PARTICIPANTS: In a joint population-based cohort study, 97 402 first-degree relatives of 21 254 TC patients who were diagnosed between 1955 and 2010 in five European countries were followed for cancer incidence...
August 2015: European Urology
D Paoli, F Giannandrea, M Gallo, R Turci, M S Cattaruzza, F Lombardo, A Lenzi, L Gandini
PURPOSE: We carried out a case-control study to investigate the possible role of occupational and environmental exposure to endocrine disruptors in the onset of testicular cancer (TC). METHODS: We evaluated 125 TC patients and 103 controls. Seminal fluid examination and organochlorine analysis were performed in all subjects. Cases and controls were also interviewed using a structured questionnaire to collect demographic information, residence, andrological medical history and dietary information...
July 2015: Journal of Endocrinological Investigation
A Srivastava, N Kreiger
In North America and most Western European countries, testicular cancer is often cited as the most common cancer among young and middle-aged men, and yet few studies have examined the relation between modifiable factors and testicular cancer risk. Data collected between 1995 and 1996 in Ontario, Canada, as part of the Enhanced Cancer Surveillance Study were used to examine the relation between the frequency of recreational, and intensity of occupational, physical activity at various life periods, including cumulative and averaged lifetime activity and risk of testicular cancer...
January 1, 2000: American Journal of Epidemiology
2016-02-06 14:28:20
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"