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9 papers 25 to 100 followers
By Joe Weatherly FM/Hospitalist-CoFounder of QuestioningMedicine and PCRAP contributor.
Päivi H Rauma, Julie A Pasco, Michael Berk, Amanda L Stuart, Heli Koivumaa-Honkanen, Risto J Honkanen, Jason M Hodge, Lana J Williams
OBJECTIVE: Osteoporosis and depression are major public health problems worldwide. Studies have reported an association between antidepressant use, mainly selective serotonin reuptake inhibitors (SSRIs), and bone mineral density (BMD), but the issue remains unclear. METHODS: This study examined data collected from 849 Australian men (aged 24-98 years) participating in the Geelong Osteoporosis Study (GOS). Bone quality was determined using quantitative ultrasound (QUS) and included the following parameters: Broadband Ultrasound Attenuation (BUA), Speed of Sound (SOS) and Stiffness Index (SI)...
May 2015: Australian and New Zealand Journal of Psychiatry
James M Bolton, Laura E Targownik, Stella Leung, Jitender Sareen, William D Leslie
BACKGROUND: Independent reports suggest that various psychotropic medications and psychiatric disorders are associated with changes in bone mineral density (BMD). The objective of this study was to clarify the independent effects of a range of mental illnesses and psychotropic medications on BMD among postmenopausal women. METHODS: Women 50 years or older with baseline BMD measured by dual-energy x-ray absorptiometry were identified in a database containing all clinical dual-energy x-ray absorptiometry test results for the Province of Manitoba, Canada...
February 2011: Journal of Clinical Psychopharmacology
Daniel H Solomon, Stephen S Johnston, Natalie N Boytsov, Donna McMorrow, Joseph M Lane, Kelly D Krohn
Hip fractures are common, morbid, costly, and associated with subsequent fractures. Historically, postfracture osteoporosis medication use rates have been poor, but have not been recently examined in a large-scale study. We conducted a retrospective, observational cohort study based on U.S. administrative insurance claims data for beneficiaries with commercial or Medicare supplemental health insurance. Eligible participants were hospitalized for hip fracture between January 1, 2002, and December 31, 2011, and aged 50 years or older at admission...
September 2014: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
M C Chapuy, M E Arlot, F Duboeuf, J Brun, B Crouzet, S Arnaud, P D Delmas, P J Meunier
BACKGROUND: Hypovitaminosis D and a low calcium intake contribute to increased parathyroid function in elderly persons. Calcium and vitamin D supplements reduce this secondary hyperparathyroidism, but whether such supplements reduce the risk of hip fractures among elderly people is not known. METHODS: We studied the effects of supplementation with vitamin D3 (cholecalciferol) and calcium on the frequency of hip fractures and other nonvertebral fractures, identified radiologically, in 3270 healthy ambulatory women (mean [+/- SD] age, 84 +/- 6 years)...
December 3, 1992: New England Journal of Medicine
Brian McNabb, Eric Vittinghoff, Richard Eastell, Ann V Schwartz, Douglas C Bauer, Kristine Ensrud, Elizabeth Barrett-Connor, Dennis M Black
CONTEXT: Women stopping alendronate are commonly monitored with serial bone mineral density (BMD) measurements, yet no information exists on how frequently or for whom these measurements should be performed. OBJECTIVE: The objective of the study was to develop a tool to guide post-alendronate BMD monitoring. DESIGN: A predictive model was constructed to estimate the time until a given percentage of women's BMD T-scores drop below a given threshold that indicates a management change (such as retreatment) would be considered...
November 2014: Journal of Clinical Endocrinology and Metabolism
Jaap W Mandema, Jenny Zheng, Cesar Libanati, Juan Jose Perez Ruixo
OBJECTIVE: Our objective was to compare the time course of bone mineral density (BMD) changes at the lumbar spine (LS) and total hip (TH) in postmenopausal women during treatment with denosumab, bisphosphonates, selective estrogen receptor modulators, PTH, or calcitonin. DATA SOURCES AND STUDY SELECTION: Data were extracted from 142 randomized controlled trials for prevention or treatment of postmenopausal osteoporosis representing over 113,000 women. DATA EXTRACTION AND DATA SYNTHESIS: The percent change from baseline in BMD was analyzed using a nonlinear least-squares random-effects meta-regression analysis...
October 2014: Journal of Clinical Endocrinology and Metabolism
Vaishali B Popat, Karim A Calis, Sophia N Kalantaridou, Vien H Vanderhoof, Deloris Koziol, James F Troendle, James C Reynolds, Lawrence M Nelson
CONTEXT: Women with primary ovarian insufficiency have significantly lower serum estradiol and T levels compared with regularly menstruating women. They also have significantly reduced bone mineral density (BMD). OBJECTIVE: The objective of the study was to evaluate the efficacy of hormone replacement in maintaining BMD in these young women. DESIGN AND SETTING: This was a randomized, double-blind, single-center, placebo-controlled clinical trial at the National Institutes of Health clinical center (Bethesda, Maryland)...
September 2014: Journal of Clinical Endocrinology and Metabolism
N E Morden, W L Schpero, R Zaha, T D Sequist, C H Colla
UNLABELLED: We evaluated the prevalence and geographic variation of short-interval (repeated in under 2 years) dual-energy X-ray absorptiometry tests (DXAs) among Medicare beneficiaries. Short-interval DXA use varied across regions (coefficient of variation = 0.64), and unlike other DXAs, rates decreased with payment cuts. INTRODUCTION: The American College of Rheumatology, through the Choosing Wisely initiative, identified measuring bone density more often than every 2 years as care "physicians and patients should question...
September 2014: Osteoporosis International
Sarah D Berry, Elizabeth J Samelson, Michael J Pencina, Robert R McLean, L Adrienne Cupples, Kerry E Broe, Douglas P Kiel
IMPORTANCE: Screening for osteoporosis with bone mineral density (BMD) is recommended for older adults. It is unclear whether repeating a BMD screening test improves fracture risk assessment. OBJECTIVES: To determine whether changes in BMD after 4 years provide additional information on fracture risk beyond baseline BMD and to quantify the change in fracture risk classification after a second BMD measure. DESIGN, SETTING, AND PARTICIPANTS: Population-based cohort study involving 310 men and 492 women from the Framingham Osteoporosis Study with 2 measures of femoral neck BMD taken from 1987 through 1999...
September 25, 2013: JAMA: the Journal of the American Medical Association
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