collection
https://read.qxmd.com/read/25042553/bone-mineral-density-and-association-of-osteoarthritis-with-fracture-risk
#21
JOURNAL ARTICLE
M Y Chan, J R Center, J A Eisman, T V Nguyen
OBJECTIVE: High body mass index (BMI) is associated with increased risk of osteoarthritis (OA) and reduced risk of fragility fracture. However, the relationship between fragility fracture and OA remained unclear. This study sought to investigate the effect of bone mineral density (BMD) in the OA-fracture relationship. METHODS: Data from 2412 women and 1452 men aged >45 years in the Dubbo Osteoporosis Epidemiology Study (DOES) were analyzed. Individuals have been followed for up to 22 years (median: 7...
September 2014: Osteoarthritis and Cartilage
https://read.qxmd.com/read/25349112/osteoporosis-conference-2014
#22
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
November 2014: Osteoporosis International
https://read.qxmd.com/read/25341476/anabolic-and-antiresorptive-therapy-for-osteoporosis-combination-and-sequential-approaches
#23
REVIEW
Felicia Cosman
In the recent Bone Key Reports review, it was noted that combinations of anabolic and antiresorptive agents have potential to improve bone density and bone strength more than either agent as monotherapy. Small clinical trials have been performed evaluating combinations of PTH1-34 (TPTD) or PTH1-84 (PTH) with a variety of antiresorptives including hormone/estrogen therapy, raloxifene, alendronate, risedronate, ibandronate, zoledronic acid, and denosumab. Most of the studies evaluate dual-energy X-ray absorptiometry outcomes, and a few trials report volumetric mineral density (BMD) by quantitative computed tomography, followed by finite element modeling to calculate bone strength...
December 2014: Current Osteoporosis Reports
https://read.qxmd.com/read/25236876/single-and-combined-effect-of-high-frequency-loading-and-bisphosphonate-treatment-on-the-bone-micro-architecture-of-ovariectomized-rats
#24
JOURNAL ARTICLE
K Hatori, G V Camargos, M Chatterjee, F Faot, K Sasaki, J Duyck, K Vandamme
UNLABELLED: Mechanical loading at high frequency affects bone. Whether this also applies to osteoporotic bone, combined or not with bisphosphonate therapy, was investigated in this animal study through imaging. An anabolic effect of high-frequency loading on osteoporotic bone, however non-synergistic with bisphosphonates, was found, thereby revealing its potential for treatment of osteoporosis. INTRODUCTION: In an effort to elucidate the effect of high-frequency (HF) loading on bone and to optimize its potential for treatment osteoporosis, this study aimed to investigate the effect of HF loading via whole body vibration (WBV), alone or in association with bisphosphonate treatment (alendronate--ALN), on the micro-architecture of ovariectomy (OVX)-induced compromised bone...
January 2015: Osteoporosis International
https://read.qxmd.com/read/25236877/persistence-at-12-months-with-denosumab-in-postmenopausal-women-with-osteoporosis-interim-results-from-a-prospective-observational-study
#25
MULTICENTER STUDY
S L Silverman, E Siris, D L Kendler, D Belazi, J P Brown, D T Gold, E M Lewiecki, A Papaioannou, C Simonelli, I Ferreira, A Balasubramanian, P Dakin, P Ho, S Siddhanti, B Stolshek, C Recknor
UNLABELLED: To determine persistence with subcutaneous denosumab every 6 months in women being treated for osteoporosis, we conducted a single-arm prospective, observational study in the United States and Canada. Among 935 patients enrolled, 12-month persistence was 82%, with 66 patients (7%) reporting serious adverse events and 19 patients (2%) reporting fractures. INTRODUCTION: Increased persistence with osteoporosis therapy is associated with reduced fracture risk...
January 2015: Osteoporosis International
https://read.qxmd.com/read/25242261/8th-pieter-van-keep-memorial-lecture-estrogen-and-bone-have-we-completed-a-full-circle
#26
T J de Villiers
Estrogen therapy was considered first-line therapy for the prevention and treatment of postmenopausal osteoporosis in 1984. Evidence from a large, randomized clinical trial in 2002 proved the efficacy of estrogen in the prevention of all types of osteoporosis-related fractures. Ironically, estrogen was relegated to second-line therapy, based on perceived safety concerns. The historical background to these decisions is presented. It is argued that this decision is not a reasonable reflection of the available evidence, especially in comparison to other available drugs...
December 2014: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/25243055/pathogenesis-of-osteoporosis
#27
JOURNAL ARTICLE
Sundeep Khosla
As for most multifactorial disorders, the pathogenesis of osteoporosis is complex, and a different set of mechanisms may be operative in any given individual. However, there are certain common causes of bone loss and increased fracture risk with aging in most people. These include genetic factors contributing to the acquisition of peak bone mass, illnesses affecting skeletal growth and development, sex steroid deficiency following the menopause in women and with aging in men, and intrinsic, age-related changes in bone metabolism...
April 2010: Translational Endocrinology & Metabolism
https://read.qxmd.com/read/25247154/factors-and-mechanisms-involved-in-the-coupling-from-bone-resorption-to-formation-how-osteoclasts-talk-to-osteoblasts
#28
REVIEW
Kyoji Ikeda, Sunao Takeshita
Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone disease such as osteoporosis ensues. Among multiple phases of the complex remodeling process, we focus in this review on factors and mechanisms that are involved in the coupling of bone formation to preceding resorption.
August 2014: Journal of Bone Metabolism
https://read.qxmd.com/read/25247156/high-dietary-sodium-intake-assessed-by-24-hour-urine-specimen-increase-urinary-calcium-excretion-and-bone-resorption-marker
#29
JOURNAL ARTICLE
Sun Mi Park, Jaehwan Jee, Ji Young Joung, Yoon Young Cho, Seo Young Sohn, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Moon Kyu Lee, Yong-Ki Min
BACKGROUND: The average dietary sodium intake of Koreans is 2.6 times higher than the World Health Organization's recommended amount. The effect of a diet high in sodium on the skeletal system, especially osteoporosis, has not previously been examined in Korean postmenopausal women with low bone mass. We assessed the daily sodium intake, and determined the impact of sodium intake on urinary calcium excretion and bone resorption marker. METHODS: A retrospective review of medical records was performed for 86 postmenopausal subjects who were initially diagnosed with osteopenia or osteoporosis at the health promotion center...
August 2014: Journal of Bone Metabolism
https://read.qxmd.com/read/25247158/efficacy-of-dual-energy-x-ray-absorptiometry-for-evaluation-of-biomechanical-properties-bone-mineral-density-and-actual-bone-strength
#30
JOURNAL ARTICLE
Sung Hwa Seo, Joomi Lee, Il Hyung Park
INTRODUCTION: Bone mineral density (BMD) is an important index in diagnosis of osteoporosis and other metabolic bone diseases, prediction of fractures, and monitoring treatment. This study was to find a more feasible technique for prediction of osteoporotic fracture between dual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) and to reveal the actual change of bone strength when BMD was changed. METHODS: Ten of these 20 specimens were used as the demineralized group and the other 10 as the control...
August 2014: Journal of Bone Metabolism
https://read.qxmd.com/read/25247344/drugs-for-postmenopausal-osteoporosis
#31
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 29, 2014: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/25252858/a-knowledge-translation-tool-improved-osteoporosis-disease-management-in-primary-care-an-interrupted-time-series-analysis
#32
JOURNAL ARTICLE
Monika Kastner, Anna M Sawka, Jemila Hamid, Maggie Chen, Kevin Thorpe, Mark Chignell, Joycelyne Ewusie, Christine Marquez, David Newton, Sharon E Straus
BACKGROUND: Osteoporosis affects over 200 million people worldwide at a high cost to healthcare systems, yet gaps in management still exist. In response, we developed a multi-component osteoporosis knowledge translation (Op-KT) tool involving a patient-initiated risk assessment questionnaire (RAQ), which generates individualized best practice recommendations for physicians and customized education for patients at the point of care. The objective of this study was to evaluate the effectiveness of the Op-KT tool for appropriate disease management by physicians...
2014: Implementation Science: IS
https://read.qxmd.com/read/25257584/a-cell-based-model-of-bone-remodeling-for-identifying-activity-of-icarrin-in-the-treatment-of-osteoporosis
#33
JOURNAL ARTICLE
Yan-Qiu Liu, Xiao-Fei Han, Tiegang Liu, Meng-Chun Cheng, Hong-Bin Xiao
The activity of icarrin (a flavonoid from Herba epimedii) was investigated in the regulation of bone remodeling, a process coupled by osteoblast-mediated bone forming and osteoclast-mediated bone resorption. By directly co-culturing mouse bone marrow stromal cells and mouse preosteoclastic RAW264.7, and transwell co-culturing rat ovarian follicular granulosa cells (FGC), a 30 % increase in alkaline phosphatase (ALP) activity and 25 % increase in estradiol level occurred. Compared with the antiresorptive drug, alendronate, and an anabolic drug, PTH1-34, icarrin possessed all of the positive effects on the co-culture by increasing ALP activity, estradiol production and decreasing tartrate-resistant acid phosphatase activity...
January 2015: Biotechnology Letters
https://read.qxmd.com/read/25259718/progressive-increases-in-bone-mass-and-bone-strength-in-an-ovariectomized-rat-model-of-osteoporosis-after-26-weeks-of-treatment-with-a-sclerostin-antibody
#34
JOURNAL ARTICLE
Xiaodong Li, Qing-Tian Niu, Kelly S Warmington, Franklin J Asuncion, Denise Dwyer, Mario Grisanti, Chun-Ya Han, Marina Stolina, Michael J Eschenberg, Paul J Kostenuik, William S Simonet, Michael S Ominsky, Hua Zhu Ke
The effects of up to 26 weeks of sclerostin antibody (Scl-Ab) treatment were investigated in ovariectomized (OVX) rats. Two months after surgery, 6-month-old osteopenic OVX rats were treated with vehicle or Scl-Ab (25 mg/kg, sc, one time per week) for 6, 12, or 26 weeks. In vivo dual-energy x-ray absorptiometry analysis demonstrated that the bone mineral density of lumbar vertebrae and femur-tibia increased progressively through 26 weeks of Scl-Ab treatment along with progressive increases in trabecular and cortical bone mass and bone strength at multiple sites...
December 2014: Endocrinology
https://read.qxmd.com/read/25263230/hip-fracture-after-first-ever-stroke-a-population-based-study
#35
JOURNAL ARTICLE
H-L Lin, H-C Lin, Y-F Tseng, H-H Liao, J A Worly, C-Y Pan, C-Y Hsu
OBJECTIVES: The aim of this study is to estimate the risk of hip fracture after first-ever stroke, using a nationwide population-base data set and a retrospective cohort design. MATERIALS AND METHODS: The cohort study involved 18,413 patients surviving a first-ever stroke during the 12-year period from 1997 to 2008. Another 18,413 control subjects were randomly selected with adjustment for age, gender and enrolled year. Stroke type, duration between stroke and hip fracture, six comorbidities and five categories of medication prior to hip fracture were investigated...
March 2015: Acta Neurologica Scandinavica
https://read.qxmd.com/read/25264411/a-literature-review-and-case-series-of-accelerating-fracture-healing-in-postmenopausal-osteoporotic-working-women
#36
REVIEW
Srinivas K Rao, Anitha P Rao
Majority of fractures do not cause significant long-term morbidity and mortality. A 10% of these fractures result in impaired fracture healing, drastically affecting quality of life in affected patients. Satisfactory healing of these osteoporotic fractures are critically important to functional recovery, morbidity, and quality of life. Some therapies for osteoporosis may affect the processes associated with bone repair. For example, bisphosphonates in experimental models are associated with increased callus size and mineralization, reduced callus remodeling, and improved mechanical strength...
September 2014: Journal of Orthopaedics
https://read.qxmd.com/read/25264795/finite-element-analysis-of-the-effect-of-basic-hip-movements-on-the-mechanical-stimulus-within-a-proximal-femur
#37
JOURNAL ARTICLE
Francisco Javier Tovar-López, Víctor Manuel Domínguez-Hernández, María Del Pilar Diez-García, Víctor Manuel Araujo-Monsalvo
Osteoporosis is a serious and multifactorial disease. The number of people affected with osteoporosis is increasing due to the lengthening of life expectancy. Currently, unlike the genetic, nutritional and hormonal factors that have been the focus of most studies of osteoporosis, mechanical stimuli that potentially can produce an increase in bone strength have not been well studied. Studies suggest that the relationship between the health of the bone and mechanical stimuli occurs through bone adaptive remodeling, which is activated by means of the shear stress transmitted by the interstitial fluid flow...
July 2014: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/25266266/association-between-bone-mineral-density-and-lumbar-disc-degeneration
#38
JOURNAL ARTICLE
Sami Salo, Ville Leinonen, Toni Rikkonen, Pauli Vainio, Jarkko Marttila, Risto Honkanen, Marjo Tuppurainen, Heikki Kröger, Joonas Sirola
OBJECTIVES: Higher vertebral bone mineral density (BMD) has been found to be related with lumbar disc degeneration (LDD), while relationship between femoral neck BMD and LDD remains controversial. The aim of our research was to study the relationship between LDD and BMD of the lumbar spine and femoral neck. STUDY DESIGN: The study population consisted of 168 postmenopausal women (aged 63.3-75.0 years, mean 68.6 years) from the prospective OSTPRE and OSTPRE-FPS study cohorts...
December 2014: Maturitas
https://read.qxmd.com/read/25266485/timing-of-the-initiation-of-bisphosphonates-after-surgery-for-fracture-healing-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#39
REVIEW
Y-T Li, H-F Cai, Z-L Zhang
SUMMARY: We performed a systematic review and meta-analysis of randomized clinical trials. Early administration of bisphosphonates (BPs) after surgery did not appear to delay fracture healing time either radiologically or clinically. Furthermore, the anti-resorptive efficacy of BPs given immediately after surgical repair should positively affect the rate of subsequent fractures. INTRODUCTION: Bisphosphonates (BPs) are widely used in the prophylaxis and treatment of osteoporosis...
February 2015: Osteoporosis International
https://read.qxmd.com/read/25269857/contributions-of-fat-mass-and-fat-distribution-to-hip-bone-strength-in-healthy-postmenopausal-chinese-women
#40
JOURNAL ARTICLE
Hong Da Shao, Guan Wu Li, Yong Liu, Yu You Qiu, Jian Hua Yao, Guang Yu Tang
The fat and bone connection is complicated, and the effect of adipose tissue on hip bone strength remains unclear. The aim of this study was to clarify the relative contribution of body fat accumulation and fat distribution to the determination of proximal femur strength in healthy postmenopausal Chinese women. This cross-sectional study enrolled 528 healthy postmenopausal women without medication history or known diseases. Total lean mass (LM), appendicular LM (ALM), percentage of lean mass (PLM), total fat mass (FM), appendicular FM (AFM), percentage of body fat (PBF), android and gynoid fat amount, android-to-gynoid fat ratio (AOI), bone mineral density (BMD), and proximal femur geometry were measured by dual energy X-ray absorptiometry...
September 2015: Journal of Bone and Mineral Metabolism
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