Timothy J Henrich, Emily Hanhauser, Francisco M Marty, Michael N Sirignano, Sheila Keating, Tzong-Hae Lee, Yvonne P Robles, Benjamin T Davis, Jonathan Z Li, Andrea Heisey, Alison L Hill, Michael P Busch, Philippe Armand, Robert J Soiffer, Marcus Altfeld, Daniel R Kuritzkes
BACKGROUND: It is unknown whether the reduction in HIV-1 reservoirs seen after allogeneic hematopoietic stem cell transplantation (HSCT) with susceptible donor cells is sufficient to achieve sustained HIV-1 remission. OBJECTIVE: To characterize HIV-1 reservoirs in blood and tissues and perform analytic antiretroviral treatment interruptions to determine the potential for allogeneic HSCT to lead to sustained, antiretroviral-free HIV-1 remission. DESIGN: Case report with characterization of HIV-1 reservoirs and immunity before and after antiretroviral interruption...
September 2, 2014: Annals of Internal Medicine