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Jing's collection of breast and thyroid

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22 papers 0 to 25 followers About breast and thyroid disease
By Jing Fan I am a endocrine surgeon, majoring breast and thyroid disease.
Angera H Kuo, Ferenc A Scheeren
No abstract text is available yet for this article.
2014: Cell Cycle
Mika Miyashita, Shinji Ohno, Akemi Kataoka, Eriko Tokunaga, Norikazu Masuda, Tadahiko Shien, Kimiko Kawabata, Miyako Takahashi
BACKGROUND: Young breast cancer survivors have specific needs related to age. Clarifying the relationships between unmet information needs and quality of life (QOL) in young breast cancer survivors can contribute to constructing a support system to enhance QOL in patients. OBJECTIVE: This study aimed to identify the unmet information needs and examine the relationships between unmet information needs and QOL in young breast cancer survivors in Japan. METHODS: Participants completed an information needs questionnaire containing 26 items, the World Health Organization Quality of Life Instrument-Short Form (WHOQOL-BREF), and a demographic and medical information questionnaire...
November 2015: Cancer Nursing
Mamatha Serasanambati, Shanmuga Reddy Chilakapati, Pavan Kumar Manikonda, Jagadeeswara Reddy Kanala, Damodar Reddy Chilakapati
This study was designed to investigate the combination effects of brucine and gemcitabine, each with anticancer properties, in MCF-7 human breast cancer cells in culture. With regard to cell viability, effects of both the drugs and their combinations were inversely proportional to dose and time. For various proportional drug combinations studied, combination effects were analysed using CompuSyn software. The analyses revealed synergistic and/or additive effects regarding cell viability, anchorage-independent growth and cell migration...
2015: Natural Product Research
Yu Zong, Li Zhu, Jiayi Wu, Xiaosong Chen, Ou Huang, Xiaochun Fei, Jianrong He, Weiguo Chen, Yafen Li, Kunwei Shen
PURPOSE: Few studies has documented early relapse in luminal B/HER2-negative breast cancer. We examined prognostic factors for early relapse among these patients to improve treatment decision-making. PATIENTS AND METHODS: A total 398 patients with luminal B/HER2-negative breast cancer were included. Kaplan-Meier curves were applied to estimate disease-free survival and Cox regression to identify prognostic factors. RESULTS: Progesterone receptor (PR) negative expression was associated with higher tumor grade (p<...
2014: PloS One
Zhengjun Yang, Bin Zhang, Likun Hou, Yegong Xie, Xuchen Cao
The purpose of this study was to investigate whether pre-operative prognostic nutritional index (PNI), an indicator of nutritional and immunological status, has an impact on the long-term outcomes in triple-negative breast cancer (TNBC) patients. This retrospective study reviewed the medical records of 382 TNBC patients who had suffered from mastectomy. Pre-operative PNI was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm(3)). The receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cutoff value of PNI...
December 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Chantal Reyna, Marie C Lee, Anne Frelick, Nazanin Khakpour, Christine Laronga, John V Kiluk
BACKGROUND: Preoperative axillary ultrasound (AUS) and fine-needle aspiration (FNA) are sensitive and specific for breast cancer nodal metastases. We hypothesize that false-negative result predicts minimal axillary disease (≤2 +nodes). METHODS: A retrospective review of breast cancer patients receiving AUS identified T1/T2 tumors and positive sentinel node with axillary dissection. Chi-square analysis was performed using Fisher's exact test. RESULTS: Of 903 AUS cases, 384 had T1/T2 tumors...
October 2014: American Journal of Surgery
S J Ioannides, P L Barlow, J M Elwood, D Porter
Aromatase inhibitors (AIs) decrease the production of oestrogen, decreasing stimulation of hormone receptor-positive breast cancer. Theoretically, AIs may be less effective in obese women, due to the greater quantity of aromatase in peripheral fatty tissue. We performed a systematic review to assess the effect of obesity on AI efficacy in breast cancer treatment. The review followed PRISMA guidelines. Studies included were interventional or observational studies with comparison groups, of postmenopausal women with hormone receptor-positive breast cancer on treatment with an AI, alone or in combination with other drugs, in which body mass index or another measure of obesity was recorded...
September 2014: Breast Cancer Research and Treatment
Ashlesha Patel, Alicia Roston, Almae Uy, Erika Radeke, Arden Roston, Louis Keith, H A Zaren
PURPOSE: The purpose of this study was to assess whether incorporation of an original reproductive health assessment and algorithm into breast cancer care helps providers appropriately manage patient reproductive health goals and to follow laboratory markers for fertility and correlate these with menstruation. METHODS: This prospective observational pilot study was set in an urban, public hospital. Newly diagnosed premenopausal breast cancer patients between 18 and 49 years old were recruited for this study prior to chemotherapy initiation...
February 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
J Castle, H Shaker, K Morris, J D Tugwood, C C Kirwan
Haematogenous spread of circulating tumour cells (CTCs) is the principle mechanism for development of metastases. Research into the enumeration and characterisation of CTCs, particularly in the last decade, has allowed the introduction of semi-automated CTC assessment in the clinical setting. In breast cancer, CTC enumeration is being used as a prognostic biomarker, a predictive biomarker of treatment response and is being assessed to guide treatment in both the early and metastatic setting. CTC characterisation has the potential to direct targeted therapies, such as HER2 therapies in HER2 negative primary breast tumour patients...
October 2014: Breast: Official Journal of the European Society of Mastology
Linda K Larkey, Denise J Roe, Karen L Weihs, Roger Jahnke, Ana Maria Lopez, Carol E Rogers, Byeongsang Oh, Jose Guillen-Rodriguez
BACKGROUND: Many breast cancer survivors experience fatigue, mood, and sleep disturbances. PURPOSE: This study aims to compare a meditative movement practice, Qigong/Tai Chi Easy (QG/TCE) with sham Qigong (SQG), testing effects of meditation/breath aspects of QG/TCE on breast cancer survivors' persistent fatigue and other symptoms. METHODS: This double-blind, randomized controlled trial tested 12 weeks of QG/TCE versus SQG on fatigue, depression, and sleep among 87 postmenopausal, fatigued breast cancer survivors, stages 0-III, age 40-75...
April 2015: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Pradyumna Kumar Sahoo, Debarshi Jana, Palash Kumar Mandal, Samindranath Basak
BACKGROUND: Invasion of breast cancer cells into blood and lymphatic vessels is one of the most important steps for metastasis. In this study the prognostic relevance of lymphangiogenesis and lymphovascular invasion (LVI) in breast cancer patients was evaluated in terms of survival. MATERIALS AND METHODS: This retrospective study concerned 518 breast cancer patients who were treated at Department of Surgical Oncology, Saroj Gupta Cancer Centre and Research Institute, Kolkata-700063, West Bengal, India, a reputed cancer centre and research institute of eastern India between January 2006 and December 2007...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Jing Liu, Pei-Fang Liu, Jun-Nan Li, Chun Qing, Yu Ji, Xi-Shan Hao, Xue-Ning Zhang
BACKGROUND: A dense breast not only reduces the sensitivity of mammography but also is a moderate independent risk factor for breast cancer. The percentage of Western women with fat breast tissue is higher aged 40 years or older. To a certain extent, mammography as a first choice of screening imaging method for Western women of this group is reasonable. Hitherto, the frequency and age distribution of mammographic breast density patterns among Chinese women had not been characterized. The purpose of this study was to investigate the frequency and age distribution of mammographic breast density patterns among a group of Chinese screening women and breast cancer patients in order to provide useful information for age-specific guidelines for breast cancer screening in Chinese women...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Katrin Sak
Flavonoids are ubiquitous in nature. They are also in food, providing an essential link between diet and prevention of chronic diseases including cancer. Anticancer effects of these polyphenols depend on several factors: Their chemical structure and concentration, and also on the type of cancer. Malignant cells from different tissues reveal somewhat different sensitivity toward flavonoids and, therefore, the preferences of the most common dietary flavonoids to various human cancer types are analyzed in this review...
July 2014: Pharmacognosy Reviews
Adam M Brufsky
Human epidermal growth factor receptor-2 (HER2) is overexpressed in up to 30% of breast cancers; HER2 overexpression is indicative of poor prognosis. Trastuzumab, an anti-HER2 monoclonal antibody, has led to improved outcomes in patients with HER2-positive breast cancer, including improved overall survival in adjuvant and first-line settings. However, a large proportion of patients with breast cancer have intrinsic resistance to HER2-targeted therapies, and nearly all become resistant to therapy after initial response...
2014: Breast Cancer: Basic and Clinical Research
Mauro Finicelli, Giovanni Benedetti, Tiziana Squillaro, Barbara Pistilli, Andrea Marcellusi, Paola Mariani, Alfredo Santinelli, Luciano Latini, Umberto Galderisi, Antonio Giordano
The events leading to breast cancer (BC) progression or recurrence are not completely understood and new prognostic markers aiming at identifying high risk-patients and to develop suitable therapy are highly demanded. Experimental evidences found in cancer cells a deregulated expression of some genes involved in governance of stem cell properties and demonstrated a relationship between stemness genes overexpression and poorly differentiated BC subtypes. In the present study 140 primary invasive BC specimens were collected...
October 30, 2014: Oncotarget
Nobuaki Matsubara, Hirofumi Mukai, Mariko Masumoto, Masaoki Sasaki, Yoichi Naito, Satoshi Fujii, Noriaki Wada
The research question of this investigation is whether the reduction rate of Ki-67 after neoadjuvant chemotherapy (NAC) could indicate a survival in patients with non-pCR. A total of 455 patients had received NAC, and subsequent surgery was analyzed retrospectively. Patients with non-pCR were divided into three subgroups according to Ki-67 change: High-reduction (the absolute value of Ki-67 was reduced by >80 % compared with that prior to NAC), Low-reduction (the absolute value of Ki-67 was reduced by 0-80 % compared with that prior to NAC), and Increase group (the absolute value of Ki-67 was increased compared with that prior to NAC)...
August 2014: Breast Cancer Research and Treatment
Miao Liu, Shu Wang, Lu Pan, Deqi Yang, Fei Xie, Peng Liu, Jiajia Guo, Jiaqing Zhang, Bo Zhou
BACKGROUND: Our goal is to validate the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram and Stanford Online Calculator (SOC) for predicting non-sentinel lymph node (NSLN) metastasis in Chinese patients, and develop a new model for better prediction of NSLN metastasis. METHODS: The MSKCC nomogram and SOC were used to calculate the probability of NSLN metastasis in 120 breast cancer patients. Univariate and multivariate analyses were performed to evaluate the relationship between NSLN metastasis and clinicopathologic factors, using the medical records of the first 80 breast cancer patients...
2014: PloS One
Matahi Moarii, Alice Pinheiro, Brigitte Sigal-Zafrani, Alain Fourquet, Martial Caly, Nicolas Servant, Véronique Stoven, Jean-Philippe Vert, Fabien Reyal
INTRODUCTION: Epigenetic modifications such as aberrant DNA methylation has long been associated with tumorogenesis. Little is known, however, about how these modifications appear in cancer progression. Comparing the methylome of breast carcinomas and locoregional evolutions could shed light on this process. METHODS: The methylome profiles of 48 primary breast carcinomas (PT) and their matched axillary metastases (PT/AM pairs, 20 cases), local recurrences (PT/LR pairs, 17 cases) or contralateral breast carcinomas (PT/CL pairs, 11 cases) were analyzed...
2014: PloS One
Jennifer Sandson Frank, David E Vance, Angela Jukkala, Karen M Meneses
Breast cancer survivors (BCSs) commonly report deficits in attention and memory, cognitive functions crucial for daily optimal functioning. Perceived deficits are reported before, during, and after adjuvant therapy and affect quality of life throughout survivorship. Deficits of attention and memory are particularly disruptive for BCSs working or attending school who report that subtle impairment diminishes their confidence and their performance at all levels of occupation. Chemotherapy and endocrine therapy contribute to attention and memory deficits, but research findings have not fully established the extent or timing of that influence...
October 2014: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Pat Whitworth, Lisette Stork-Sloots, Femke A de Snoo, Paul Richards, Michael Rotkis, Jennifer Beatty, Angela Mislowsky, James V Pellicane, Bichlien Nguyen, Laura Lee, Charles Nash, Mark Gittleman, Stephanie Akbari, Peter D Beitsch
PURPOSE: The purpose of the NBRST study is to compare a multigene classifier to conventional immunohistochemistry (IHC)/fluorescence in situ hybridization (FISH) subtyping to predict chemosensitivity as defined by pathological complete response (pCR) or endocrine sensitivity as defined by partial response. METHODS: The study includes women with histologically proven breast cancer, who will receive neoadjuvant chemotherapy (NCT) or neoadjuvant endocrine therapy. BluePrint in combination with MammaPrint classifies patients into four molecular subgroups: Luminal A, Luminal B, HER2, and Basal...
October 2014: Annals of Surgical Oncology
2014-08-10 11:15:24
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