Hamid Nasri, Mohammad Reza Ardalan
No abstract text is available yet for this article.
2013: Journal of Renal Injury Prevention
Muhammed Mubarak, Hamid Nasri
No abstract text is available yet for this article.
2013: Journal of Renal Injury Prevention
Pavan Malleshappa
No abstract text is available yet for this article.
2013: Journal of Renal Injury Prevention
Muhammed Mubarak, Hamid Nasri
Immunoglobulin M (IgM) is the largest antibody molecule and is deposited in the glomeruli in a wide variety of both primary and secondary glomerulopathies. The data on its pathogenic role are conflicting till date. A recent study provides evidence for the involvement of natural antibody IgM in fixing and activating complement and causing glomerular injury, proteinuria, and glomerulosclerosis in an animal model. This finding is important in understanding the pathogenesis of the related disorder of IgM nephropathy...
2014: Journal of Renal Injury Prevention
Davide Rolla, Novella Conti, Francesca Ansaldo, Laura Panaro, Tiziano Lusenti
INTRODUCTION: We report a case of a patient with acute renal failure in Lyme disease-associated focal proliferative mesangial nephropathy. Lyme disease is a vector-borne disease caused by Borrelia burgdorferi, transmitted by the bite of an infected ixodes tick. Post-infectious glomerulonephritis (GN)secondary to Borrelia burgdorferi infection in man could be fatal, as it is in canine Lyme borreliosis. CASE: A 61-year old man with chronic ethanolic hepatitis was admitted to a provincial hospital, complaining of nausea, diarrhoea and loss of his sense of taste...
2014: Journal of Renal Injury Prevention
Nisha Bansal, Amanda Hyre Anderson, Wei Yang, Robert H Christenson, Christopher R deFilippi, Rajat Deo, Daniel L Dries, Alan S Go, Jiang He, John W Kusek, James P Lash, Dominic Raj, Sylvia Rosas, Myles Wolf, Xiaoming Zhang, Michael G Shlipak, Harold I Feldman
High-sensitivity troponin T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) strongly predict heart failure (HF) in the general population. However, the interpretation of levels of these biomarkers as predictors of HF is uncertain among patients with CKD. Here, we investigated whether hsTnT and NT-proBNP are associated with incident HF among patients with CKD. In a prospective cohort analysis, we studied 3483 people with CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study recruited from June of 2003 to August of 2008 who were free of HF at baseline...
April 2015: Journal of the American Society of Nephrology: JASN
Jara Caro, Elena Gutiérrez-Solís, Jorge Rojas-Rivera, Irene Agraz, Natalia Ramos, Cristina Rabasco, Mario Espinosa, Alfonso Valera, Mónica Martín, Miguel Ángel Frutos, Lara Perea, Gema Fernández Juárez, Javier Ocaña, David Arroyo, Marian Goicoechea, Laura Fernández, Aniana Oliet, Yolanda Hernández, Ana Romera, Alfons Segarra, Manuel Praga
BACKGROUND: Although tacrolimus is recommended by KDIGO Clinical Practice Guideline for Glomerulonephritis for the treatment of idiopathic membranous nephropathy (MN), little is known about factors that influence response and relapse of the disease after tacrolimus therapy. METHODS: Multicentre study that collected 122 MN patients with nephrotic syndrome and stable renal function treated with tacrolimus. Duration of treatment was 17.6 ± 7.2 months, including a full-dose and a tapering period...
March 2015: Nephrology, Dialysis, Transplantation
Mariangela Peruzzi, Leonardo De Luca, Henrik S Thomsen, Enrico Romagnoli, Fabrizio D'Ascenzo, Massimo Mancone, Gennaro Sardella, Luigi Lucisano, Antonio Abbate, Giacomo Frati, Giuseppe Biondi-Zoccai
Contrast-induced nephropathy is a common complication of iodinated contrast administration. Statins may reduce the risk of contrast-induced nephropathy, but data remain inconclusive. We summarized the evidence based on statins for the prevention of contrast-induced nephropathy with a network meta-analysis. Randomized trials focusing on statins were searched and pooled with random-effect odds ratios. A total of 14 trials (6,160 patients) were included, focusing on atorvastatin (high/low dose), rosuvastatin (high dose), simvastatin (high/low dose), and placebo or no statin therapy before contrast administration...
2014: BioMed Research International
Hicham I Cheikh Hassan, Frank Brennan, Gemma Collett, Elizabeth A Josland, Mark A Brown
CONTEXT: Pruritus and restless legs syndrome (RLS) frequently affect patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), impacting the quality of life. Gabapentin (1-aminomethyl cyclohexane acetic acid) alleviates these symptoms in hemodialysis (HD) patients, but data are lacking for patients on the conservative pathway. OBJECTIVES: To determine the safety and effectiveness of gabapentin for pruritus or RLS in conservatively managed patients (n = 34) with CKD and ESKD...
April 2015: Journal of Pain and Symptom Management
Margaret Ryan, Kyle Ware, Zahida Qamri, Anjali Satoskar, Haifeng Wu, Gyongyi Nadasdy, Brad Rovin, Lee Hebert, Tibor Nadasdy, Sergey V Brodsky
BACKGROUND: Excessive anticoagulation with warfarin can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients, especially in those with chronic kidney disease (CKD). This condition was described as warfarin-related nephropathy (WRN). Recent evidence suggests that WRN-like syndromes are not confined to anticoagulation with warfarin, but may be seen with other anticoagulants, such as dabigatran. The aim of this study was to investigate dabigatran effects on kidney function in an animal model of CKD and possible pathogenic mechanisms of AKI...
December 2014: Nephrology, Dialysis, Transplantation
Ronald R Reichel
BACKGROUND: Acute kidney injury (AKI) is frequently encountered in the nephrology practice. Serum creatinine, with its many shortcomings, is still the main biomarker used to detect AKI. METHODS: This review focuses on recent advances in definition, diagnosis, risk factors, and molecular mechanisms of AKI. In addition, specific AKI syndromes such as contrast-induced AKI, hepatorenal syndrome, and acute decompensated heart failure are discussed. The connection between AKI and subsequent chronic kidney disease and recent developments in renal replacement therapy are also covered...
2014: Ochsner Journal
L Nicholas Cossey, Nidia Messias, Erick Messias, Patrick D Walker, Fred G Silva
In patients with diabetic nephropathy (DN), the spectrum of immunoglobulin A (IgA)-dominant/codominant glomerular deposition (IgAGD) has not been addressed in the literature. The aim of our study is to detail the clinicopathological and outcome findings in patients with DN and IgAGD. Our database was retrospectively searched over a 10-year period for patients with DN and IgAGD. A total of 132 patients were included in the study, 55 with outcome data. All cases were reviewed by light microscopy, immunofluorescence, and electron microscopy...
November 2014: Human Pathology
Wolfgang C Winkelmayer
No abstract text is available yet for this article.
September 16, 2014: Annals of Internal Medicine
Vasilios Papademetriou, Laura Lovato, Michael Doumas, Eric Nylen, Amy Mottl, Robert M Cohen, William B Applegate, Zubin Puntakee, Jean Francois Yale, William C Cushman
Results of the main Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial indicate that intensive glucose lowering increases cardiovascular and all-cause mortality. As the contribution of mild-to-moderate chronic kidney disease (CKD) to these risks is not known, we assessed the impact on cardiovascular outcomes in this population. Renal function data were available on 10,136 patients of the original ACCORD cohort. Of those, 6,506 were free of CKD at baseline and 3,636 met the criteria for CKD. Participants were randomly assigned to a treatment strategy of either intensive or standard glycemic goal...
March 2015: Kidney International
Börje Haraldsson
No abstract text is available yet for this article.
December 19, 2013: New England Journal of Medicine
Claudio Bazzi, Virginia Rizza, Giulia Olivieri, Daniela Casellato, Giuseppe D'Amico
BACKGROUND: Proteinuria, the hallmark of glomerular diseases, is an independent predictor of end-stage renal disease (ESRD) progression. Proteinuria is a mixture of proteins of different molecular weight (MW) dependent on alterations of glomerular filtration barrier (GFB) and reabsorption impairment by proximal tubular epithelial cells (PTECs). We aimed to evaluate the excretion of different-MW proteins according to the tubulo-interstitial damage marker N-acetyl-β-D-glucosaminidase (NAG) in glomerulonephritides (GNs)...
October 2015: Journal of Nephrology
M C Preciado-Puga, J M Malacara, M E Fajardo-Araujo, K Wröbel, K Wröbel, C Kornhauser-Araujo, M E Garay-Sevilla
Hyperglycemia induces tissue damage and complications by mechanisms that produce advanced glycation end-products (AGEs) and inflammation.To investigate the factors associated with the progression of complications in Type 2 diabetes patients.We recruited 157 patients (110 women and 47 men) with diabetes for more than 5 years who were non-smokers and did not have current infections or chronic diseases. Patients were grouped according to neuropathy, nephropathy, and retinopathy status: without (I), slight or moderate (II), and severe complications (III)...
September 2014: Experimental and Clinical Endocrinology & Diabetes
Yoshinosuke Shimamura, Takahiro Tsushima, Norihito Moniwa, Koichi Hasegawa, Yayoi Ogawa, Hideki Takizawa
INTRODUCTION: Tubulointerstitial nephritis and uveitis syndrome is a disorder characterized by a combination of acute tubulointerstitial nephritis and uveitis. Immunoglobulin A nephropathy is defined by the presence of immunoglobulin A deposits in glomerular mesangial areas. In this report, we describe a rare case of tubulointerstitial nephritis and uveitis syndrome complicated by immunoglobulin A nephropathy and Graves' disease, which was successfully treated with corticosteroids. To the best of our knowledge, this is the first time such a case has been documented since tubulointerstitial nephritis and uveitis syndrome was first described...
2014: Journal of Medical Case Reports
Guang-dong Sun, Wen-peng Cui, Qiao-yan Guo, Li-ning Miao
Diabetic nephropathy (DN) belongs to debilitating microvascular complications of diabetes and is the leading cause of end-stage renal diseases worldwide. Furthermore, outcomes from the DCCT/EDIC study showed that DN often persists and progresses despite intensive glucose control in many diabetes patients, possibly as a result of prior episode of hyperglycemia, which is called "metabolic memory." The underlying mechanisms responsible for the development and progression of DN remain poorly understood...
2014: Journal of Diabetes Research
Sai-Jun Zhou, Lian Bai, Lin Lv, Rui Chen, Chun-Jun Li, Xiang-Yang Liu, De-Min Yu, Pei Yu
Accumulating evidence has implicated that liraglutide, one of the human glucagon‑like peptide‑1 (GLP‑1) analogues, elicits protective effects on diabetic nephropathy; however, the mechanism has yet to be fully elucidated. The present study aimed to assess the effect and underlying mechanisms of liraglutide in diabetic nephropathy. Wistar rats with streptozotocin‑induced diabetes mellitus were subcutaneously injected with liraglutide or phosphate buffer for 12 weeks at a dose of 0.3 mg/kg/12 h. The biochemical parameters were determined, renal histological examination was performed by hematoxylin and eosin and periodic acid Schiff base staining, and the mRNA levels of nuclear factor κB (NF‑κB) and endothelial nitric oxide synthase (eNOS) were assessed by quantitative polymerase chain reaction...
November 2014: Molecular Medicine Reports
2014-09-15 01:40:20
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