collection
https://read.qxmd.com/read/36972961/subanaesthetic-single-dose-ketamine-as-an-adjunct-to-opioid-analgesics-for-acute-pain-management-in-the-emergency-department-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Stine Fjendbo Galili, Lone Nikolajsen, Nicholas Papadomanolakis-Pakis
OBJECTIVE: To evaluate the effectiveness of a subanaesthetic single-dose ketamine (SDK) as an adjunct to opioids for acute pain in emergency department (ED) settings. DESIGN: Systematic review and meta-analysis. METHODS: A systematic search was performed in MEDLINE, Embase, Scopus and Web of Science through March 2022. Randomised controlled trials (RCTs) that investigated SDK as an adjunct to opioids in adult patients for any painful condition in ED settings were selected...
March 27, 2023: BMJ Open
https://read.qxmd.com/read/36849784/a-prospective-observational-study-of-the-efficacy-of-ketamine-for-rescue-analgesia-in-the-postanesthesia-recovery-unit
#2
JOURNAL ARTICLE
Carole-Anne Potvin, James Green, Bo Pan, Yazid N Al Hamarneh, Derek Dillane
BACKGROUND: Early severe postoperative pain is frequently resistant to management with opioid analgesia alone. Perioperative low-dose ketamine as an analgesia adjunct has been studied extensively. Its efficacy as a rescue analgesic in the postanesthesia care unit (PACU) has not been determined. The objective of this study was to evaluate the analgesic efficacy of low-dose bolus ketamine for opioid-resistant pain in the PACU by measuring its effect on numerical rating scale (NRS) pain scores and opioid requirement...
May 2023: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/23663314/ketamine-in-pain-management
#3
REVIEW
Jan Persson
For ketamine's fiftieth birthday, a narrative review of this unique drug in pain management is presented. Its history is traced from its conception, and its heritage, as a phencyclidine offspring, delineated. The earliest roots of the conceptions concerning the mechanisms of action are sought, and then followed in preclinical as well as clinical research. The major proposed mechanisms in the literature are commented on and evaluated. The growth of the clinical evidence for perioperative pain, acute pain, and chronic pain is followed from early attempts to systematic reviews...
June 2013: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/19189986/ketamine-has-no-effect-on-bispectral-index-during-stable-propofol-remifentanil-anaesthesia
#4
RANDOMIZED CONTROLLED TRIAL
D Faraoni, J-C Salengros, E Engelman, B Ickx, L Barvais
BACKGROUND: Ketamine 0.15-1 mg kg(-1) decreases postoperative morphine consumption, but 0.5 mg kg(-1) is associated with an increase in the bispectral index (BIS) values that can lead to an overdose of hypnotic agents. The purpose of our investigation was to study the effect of ketamine 0.2 mg kg(-1) administered over a 5 min period on the BIS during stable target-controlled infusion (TCI) propofol-remifentanil general anaesthesia. METHODS: Thirty ASA I or II patients undergoing abdominal laparoscopic surgery were included in this double-blind, randomized study...
March 2009: British Journal of Anaesthesia
https://read.qxmd.com/read/17389691/predictive-performance-of-the-domino-hijazi-and-clements-models-during-low-dose-target-controlled-ketamine-infusions-in-healthy-volunteers
#5
COMPARATIVE STUDY
A R Absalom, M Lee, D K Menon, S R Sharar, T De Smet, J Halliday, M Ogden, P Corlett, G D Honey, P C Fletcher
BACKGROUND: Healthy volunteers received low-dose target-controlled infusions (TCI) of ketamine controlled by the Domino model while cognitive function tests and functional neuroimaging were performed. The aim of the current study was to assess the predictive performance of the Domino model during these studies, and compare it with that of three other ketamine models. METHODS: Fifty-eight volunteers received ketamine administered by a TCI device on one or more occasions at target concentrations of either 50, 100, or 200 ng ml-1...
May 2007: British Journal of Anaesthesia
https://read.qxmd.com/read/23480625/the-emerging-use-of-ketamine-for-anesthesia-and-sedation-in-traumatic-brain-injuries
#6
REVIEW
Lee C Chang, Sally R Raty, Jaime Ortiz, Neil S Bailard, Sanjay J Mathew
Traditionally, the use of ketamine for patients with traumatic brain injuries is contraindicated due to the concern of increasing intracranial pressure (ICP). These concerns, however, originated from early studies and case reports that were inadequately controlled and designed. Recently, the concern of using ketamine in these patients has been challenged by a number of published studies demonstrating that the use of ketamine was safe in these patients. This article reviews the current literature in regards to using ketamine in patients with traumatic brain injuries in different clinical settings associated with anesthesia, as well as reviews the potential mechanisms underlying the neuroprotective effects of ketamine...
June 2013: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/25064742/the-effect-of-ketamine-on-intracranial-and-cerebral-perfusion-pressure-and-health-outcomes-a-systematic-review
#7
REVIEW
Lindsay Cohen, Valerie Athaide, Maeve E Wickham, Mary M Doyle-Waters, Nicholas G W Rose, Corinne M Hohl
STUDY OBJECTIVE: We synthesize the available evidence on the effect of ketamine on intracranial and cerebral perfusion pressures, neurologic outcomes, ICU length of stay, and mortality. METHODS: We developed a systematic search strategy and applied it to 6 electronic reference databases. We completed a gray literature search and searched medical journals as well as the bibliographies of relevant articles. We included randomized and nonrandomized prospective studies that compared the effect of ketamine with another intravenous sedative in intubated patients and reported at least 1 outcome of interest...
January 2015: Annals of Emergency Medicine
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