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Collections Shrewsbury and Telford Hospita...

Shrewsbury and Telford Hospital NHS Trust staff publications

https://read.qxmd.com/read/35296643/antibody-decay-t-cell-immunity-and-breakthrough-infections-following-two-sars-cov-2-vaccine-doses-in-inflammatory-bowel-disease-patients-treated-with-infliximab-and-vedolizumab
#21
JOURNAL ARTICLE
Simeng Lin, Nicholas A Kennedy, Aamir Saifuddin, Diana Muñoz Sandoval, Catherine J Reynolds, Rocio Castro Seoane, Sherine H Kottoor, Franziska P Pieper, Kai-Min Lin, David K Butler, Neil Chanchlani, Rachel Nice, Desmond Chee, Claire Bewshea, Malik Janjua, Timothy J McDonald, Shaji Sebastian, James L Alexander, Laura Constable, James C Lee, Charles D Murray, Ailsa L Hart, Peter M Irving, Gareth-Rhys Jones, Klaartje B Kok, Christopher A Lamb, Charlie W Lees, Daniel M Altmann, Rosemary J Boyton, James R Goodhand, Nick Powell, Tariq Ahmad
Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccine-induced immune responses and breakthrough infections in patients with inflammatory bowel disease, who are treated either with the anti-TNF antibody, infliximab, or with vedolizumab targeting a gut-specific anti-integrin that does not impair systemic immunity. Geometric mean [SD] anti-S RBD antibody concentrations are lower and half-lives shorter in patients treated with infliximab than vedolizumab, following two doses of BNT162b2 (566...
March 16, 2022: Nature Communications
https://read.qxmd.com/read/35787029/exploring-pregnant-women-s-experiences-of-stopping-smoking-with-an-incentive-scheme-with-enhanced-support-a-qualitative-study
#22
JOURNAL ARTICLE
Fiona C McCormack, Rachel C Hopley, Elizabeth H Boath, Sian L Parry, Suzie M Roscoe, Antony Stewart, Victoria A Birch
AIM: This study aims to understand pregnant women's experiences of smoking cessation with an incentive scheme in a deprived UK city. This is important because smoking cessation with pregnant women is one of the most crucial public health initiatives to promote, and is particularly challenging in deprived areas. While financial incentive schemes are controversial, there is a need to better understand pregnant women's experiences. The scheme combined quasi-financial incentives (shopping vouchers) for validated quits (carbon monoxide (CO) validated at < 10 ppm), enhanced support from smoking cessation advisors, the opportunity to identify a 'Significant Other Supporter' and nicotine replacement therapy...
July 5, 2022: Perspectives in Public Health
https://read.qxmd.com/read/34848515/outcomes-after-perioperative-sars-cov-2-infection-in-patients-with-proximal-femoral-fractures-an-international-cohort-study
#23
JOURNAL ARTICLE
(no author information available yet)
OBJECTIVES: Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis. SETTING: Prospective, international, multicentre, observational cohort study...
November 30, 2021: BMJ Open
https://read.qxmd.com/read/35774694/surgical-fixation-of-three-and-four-part-proximal-humeral-fractures-using-the-proximal-humeral-interlocking-system-plate
#24
JOURNAL ARTICLE
Ahmed Y Saber, Umar N Said, Abdelmonem H Abdelmonem, Hassan Elsayed, Mohamed Taha, Walid Hussein, Khalid Al-Hashimi, Omar El-Omar, Mohamed Elbeshbeshy
Introduction The management of proximal humeral fractures ranges greatly from conservative management to surgical treatment. For those fractures requiring surgical treatment, internal fixation is the primary method. The aim of internal fixation is to achieve rigid fracture fixation until union occurs, return of shoulder range of motion, and minimise intra-and postoperative complications. The aim of this study was to evaluate the results of the Proximal Humeral Interlocking System Plate (PHILOS) used for the treatment of three-and four-part proximal humeral fractures...
May 2022: Curēus
https://read.qxmd.com/read/35724686/worth-the-paper-it-s-written-on-a-cross-sectional-study-of-medical-certificate-of-stillbirth-accuracy-in-the-uk
#25
JOURNAL ARTICLE
Michael P Rimmer, Ian Henderson, William Parry-Smith, Olivia Raglan, Jennifer Tamblyn, Alexander E P Heazell, Lucy E Higgins
BACKGROUND: The Medical Certificate of Stillbirth (MCS) records data about a baby's death after 24 weeks of gestation but before birth. Major errors that could alter interpretation of the MCS were widespread in two UK-based regional studies. METHODS: A multicentre evaluation was conducted, examining MCS issued 1 January 2018 to 31 December 2018 in 76 UK obstetric units. A systematic case-note review of stillbirths was conducted by Obstetric and Gynaecology trainees, generating individual 'ideal MCSs' and comparing these to the actual MCS issued...
June 20, 2022: International Journal of Epidemiology
https://read.qxmd.com/read/35698674/holt-oram-syndrome-an-incidental-diagnosis
#26
Mehak Gupta, Ayodeji Dosu, Jayesh Makan
Holt-Oram syndrome is a rare autosomal dominant disorder which occurs because of mutations in the TBX5 genes. Most notable manifestations include musculoskeletal deformities, predominantly affecting the upper limbs, and congenital heart defects. Presentation could be multifaceted leading to delay in diagnosis. We describe an interesting incidental diagnosis of Holt-Oram syndrome in a young female adult who accompanied her son to the clinic. He had undergone closure of both atrial septal defect (ASD) and patent ductus arteriosus (PDA) in his infancy...
May 2022: Curēus
https://read.qxmd.com/read/35671327/radiotherapy-to-the-prostate-for-men-with-metastatic-prostate-cancer-in-the-uk-and-switzerland-long-term-results-from-the-stampede-randomised-controlled-trial
#27
RANDOMIZED CONTROLLED TRIAL
Chris C Parker, Nicholas D James, Christopher D Brawley, Noel W Clarke, Adnan Ali, Claire L Amos, Gerhardt Attard, Simon Chowdhury, Adrian Cook, William Cross, David P Dearnaley, Hassan Douis, Duncan C Gilbert, Clare Gilson, Silke Gillessen, Alex Hoyle, Rob J Jones, Ruth E Langley, Zafar I Malik, Malcolm D Mason, David Matheson, Robin Millman, Mary Rauchenberger, Hannah Rush, J Martin Russell, Hannah Sweeney, Amit Bahl, Alison Birtle, Lisa Capaldi, Omar Din, Daniel Ford, Joanna Gale, Ann Henry, Peter Hoskin, Mohammed Kagzi, Anna Lydon, Joe M O'Sullivan, Sangeeta A Paisey, Omi Parikh, Delia Pudney, Vijay Ramani, Peter Robson, Narayanan Nair Srihari, Jacob Tanguay, Mahesh K B Parmar, Matthew R Sydes
BACKGROUND: STAMPEDE has previously reported that radiotherapy (RT) to the prostate improved overall survival (OS) for patients with newly diagnosed prostate cancer with low metastatic burden, but not those with high-burden disease. In this final analysis, we report long-term findings on the primary outcome measure of OS and on the secondary outcome measures of symptomatic local events, RT toxicity events, and quality of life (QoL). METHODS AND FINDINGS: Patients were randomised at secondary care sites in the United Kingdom and Switzerland between January 2013 and September 2016, with 1:1 stratified allocation: 1,029 to standard of care (SOC) and 1,032 to SOC+RT...
June 2022: PLoS Medicine
https://read.qxmd.com/read/34237774/mapping-the-human-genetic-architecture-of-covid-19
#28
MULTICENTER STUDY
(no author information available yet)
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2 , host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity...
December 2021: Nature
https://read.qxmd.com/read/35278112/learning-curves-in-minimally-invasive-pancreatic-surgery-a-systematic-review
#29
JOURNAL ARTICLE
Gayle Fung, Menazir Sha, Basir Kunduzi, Farid Froghi, Saad Rehman, Saied Froghi
BACKGROUND: The learning curve of new surgical procedures has implications for the education, evaluation and subsequent adoption. There is currently no standardised surgical training for those willing to make their first attempts at minimally invasive pancreatic surgery. This study aims to ascertain the learning curve in minimally invasive pancreatic surgery. METHODS: A systematic search of PubMed, Embase and Web of Science was performed up to March 2021. Studies investigating the number of cases needed to achieve author-declared competency in minimally invasive pancreatic surgery were included...
March 12, 2022: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/35287957/the-global-level-of-harm-among-surgical-professionals-during-the-covid-19-pandemic-a-multinational-cross-sectional-cohort-study
#30
JOURNAL ARTICLE
Mohamed Abouelazayem, Yirupaiahgari K S Viswanath, Ali Haider Bangash, Johnn Henry Herrera Kok, Chandra Cheruvu, Chetan Parmar, Semra Demirli Atici, Wah Yang, Michail Galanis, Francesco Di Maggio, Arda Isik, Samik Kumar Bandyopadhyay
BACKGROUND: Health care workers, including surgical professionals, experienced psychological burnout and physical harm during the coronavirus 2019 pandemic. This global survey investigated the coronavirus 2019 pandemic impact on psychological and physical health. METHODS: We conducted a global cross-sectional survey between February 18, 2021 and March 13, 2021. The primary outcome was to assess the psychological burnout, fulfillment, and self-reported physical level of harm...
March 11, 2022: Surgery
https://read.qxmd.com/read/35279270/observation-versus-screening-spinal-mri-and-pre-emptive-treatment-for-spinal-cord-compression-in-patients-with-castration-resistant-prostate-cancer-and-spinal-metastases-in-the-uk-prompts-an-open-label-randomised-controlled-phase-3-trial
#31
JOURNAL ARTICLE
David Dearnaley, Victoria Hinder, Adham Hijab, Gail Horan, Narayanan Srihari, Philip Rich, J Graeme Houston, Ann M Henry, Stephanie Gibbs, Ram Venkitaraman, Clare Cruickshank, Shama Hassan, Alec Miners, Malcolm Mason, Ian Pedley, Heather Payne, Susannah Brock, Robert Wade, Angus Robinson, Omar Din, Kathryn Lees, John Graham, Jane Worlding, Julia Murray, Chris Parker, Clare Griffin, Aslam Sohaib, Emma Hall
BACKGROUND: Early diagnosis of malignant spinal cord compression (SCC) is crucial because pretreatment neurological status is the major determinant of outcome. In metastatic castration-resistant prostate cancer, SCC is a clinically significant cause of disease-related morbidity and mortality. We investigated whether screening for SCC with spinal MRI, and pre-emptive treatment if radiological SCC (rSCC) was detected, reduced the incidence of clinical SCC (cSCC) in asymptomatic patients with metastatic castration-resistant prostate cancer and spinal metastasis...
March 10, 2022: Lancet Oncology
https://read.qxmd.com/read/35291633/a-systematic-review-of-long-distance-triathlon-musculoskeletal-injuries
#32
JOURNAL ARTICLE
John-Henry Rhind, Debashis Dass, Andrew Barnett, Michael Carmont
The distribution of injuries affecting long-distance triathletes is yet to be fully understood. A systematic review was performed of the clinical literature to determine the epidemiology of musculoskeletal injuries affecting long-distance triathletes. Searched databases in Feb 2020 were PubMed, Medline, EMBASE, EMCARE, and CINHAL databases. Published observational research articles related to the incidence or prevalence of musculoskeletal injuries in long-distance triathletes (competing at "Ironman" full distance or greater), written in the English language and not restricted by age or gender or date were eligible...
January 2022: Journal of Human Kinetics
https://read.qxmd.com/read/35318203/severe-hyponatraemia-in-two-patients-with-breast-cancer-caused-by-low-dose-cyclophosphamide-and-precipitated-by-aprepitant
#33
JOURNAL ARTICLE
Shefali Parikh, Laura Pettit, Huzeifa AbdelGadir
Two postmenopausal women with breast cancer developed acute confusion and seizures, less than 24 hours after the first cycle of neoadjuvant chemotherapy with fluorouracil, epirubicin and low-dose cyclophosphamide. They were found to have severe, life-threatening hyponatraemia with sodium levels of 113 and 115 mEq/L, respectively. Both women made a full recovery within 24 hours of admission with slow correction of sodium levels. Following investigational workup, the most likely diagnosis was cyclophosphamide-associated syndrome of inappropriate antidiuretic hormone secretion (SIADH)...
March 22, 2022: BMJ Case Reports
https://read.qxmd.com/read/35314774/the-changing-landscape-for-the-management-of-patients-with-neovascular-amd-brolucizumab-in-clinical-practice
#34
REVIEW
Ian Pearce, Winfried Amoaku, Clare Bailey, Louise Downey, Richard Gale, Faruque Ghanchi, Robin Hamilton, Sajjad Mahmood, Geeta Menon, Jenny Nosek, James Talks, Yit Yang
Untreated neovascular age-related macular degeneration (nAMD) can lead to severe and permanent visual impairment. The chronic nature of the disease can have a significant impact on patients' quality of life and an economic and time burden on medical retina (MR) services, with the care need outweighing the growth of resources that clinical services can access. The introduction of a new treatment into clinical services can be challenging, especially for services that are already under capacity constraints. Guidance for practical implementation is therefore helpful...
March 21, 2022: Eye
https://read.qxmd.com/read/34889978/common-low-frequency-rare-and-ultra-rare-coding-variants-contribute-to-covid-19-severity
#35
JOURNAL ARTICLE
Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro, Sergio Daga, Francesca Fava, Elisa Benetti, Sara Amitrano, Mirella Bruttini, Maria Palmieri, Susanna Croci, Mirjam Lista, Giada Beligni, Floriana Valentino, Ilaria Meloni, Marco Tanfoni, Francesca Minnai, Francesca Colombo, Enrico Cabri, Maddalena Fratelli, Chiara Gabbi, Stefania Mantovani, Elisa Frullanti, Marco Gori, Francis P Crawley, Guillaume Butler-Laporte, Brent Richards, Hugo Zeberg, Miklos Lipcsey, Michael Hultström, Kerstin U Ludwig, Eva C Schulte, Erola Pairo-Castineira, John Kenneth Baillie, Axel Schmidt, Robert Frithiof, Francesca Mari, Alessandra Renieri, Simone Furini
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity...
December 10, 2021: Human Genetics
https://read.qxmd.com/read/35360942/the-british-orthopaedic-surgery-surveillance-study-slipped-capital-femoral-epiphysis-the-epidemiology-and-two-year-outcomes-from-a-prospective-cohort-in-great-britain
#36
JOURNAL ARTICLE
Daniel C Perry, Barbara Arch, Duncan Appelbe, Priya Francis, Joanna Craven, Fergal P Monsell, Paula Williamson, Marian Knight
AIMS: The aim of this study was to inform the epidemiology and treatment of slipped capital femoral epiphysis (SCFE). METHODS: This was an anonymized comprehensive cohort study, with a nested consented cohort, following the the Idea, Development, Exploration, Assessment, Long-term study (IDEAL) framework. A total of 143 of 144 hospitals treating SCFE in Great Britain participated over an 18-month period. Patients were cross-checked against national administrative data and potential missing patients were identified...
April 2022: Bone & Joint Journal
https://read.qxmd.com/read/35576299/establishment-of-virtual-fracture-clinic-in-princess-royal-hospital-telford-experience-and-recommendations-during-the-first-9-months
#37
JOURNAL ARTICLE
Tahir Khaleeq, Patrick Lancaster, Keji Fakoya, Martin Black, Julie Littlehales, Pedro Ferreira, Usman Ahmed
BACKGROUND: Virtual fracture clinics (VFC) have been shown to be a safe and cost-effective way of managing outpatient referrals to the orthopaedic department. During the coronavirus pandemic there has been a push to reduce unnecessary patient contact whilst maintaining patient safety. METHODS: A protocol was developed by the clinical team in collaboration with Advanced Physiotherapy Practitioners (APP) on how to manage common musculoskeletal presentations to A&E prior to COVID as part of routine service development...
April 2022: Journal of Ayub Medical College, Abbottabad: JAMC
https://read.qxmd.com/read/35396938/endoscopically-assisted-reconstruction-of-chronic-achilles-tendon-ruptures-and-re-ruptures-using-a-semitendinosus-autograft-is-a-viable-alternative-to-pre-existing-techniques
#38
JOURNAL ARTICLE
Niklas Nilsson, Baldvin Gunnarsson, Michael R Carmont, Annelie Brorsson, Jón Karlsson, Katarina Nilsson Helander
PURPOSE: Achilles tendon ruptures are termed chronic after a delay in treatment for more than 4 weeks. The literature advocates surgical treatment with reconstruction to regain ankle push-off strength. The preferred technique is, however, still unknown and is often individualized. This study aims to present the technique and clinical outcome of an endoscopically assisted free semitendinosus reconstruction of chronic Achilles tendon rupture and Achilles tendon re-ruptures with delayed representation...
April 9, 2022: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/35419245/patient-outcomes-related-to-in-hospital-delays-in-appendicectomy-for-appendicitis-a-retrospective-study
#39
JOURNAL ARTICLE
Oliver Claydon, Billy Down, Sidharth Kumar
Background and objective In many hospitals, the availability of operating theatres and access to senior surgical and anaesthetic support diminish during night hours. Therefore, urgent surgery is sometimes postponed until the following morning rather than performed overnight, if it is judged to be safe. In this study, we aimed to determine if a delay in laparoscopic appendicectomy in cases of acute appendicitis of over 12 hours, analogous to an overnight delay, correlated with worse patient outcomes. Our primary outcome was delayed discharge from the hospital...
March 2022: Curēus
https://read.qxmd.com/read/35411939/abiraterone-acetate-plus-prednisolone-for-metastatic-patients-starting-hormone-therapy-5-year-follow-up-results-from-the-stampede-randomised-trial-nct00268476
#40
RANDOMIZED CONTROLLED TRIAL
Nicholas D James, Noel W Clarke, Adrian Cook, Adnan Ali, Alex P Hoyle, Gerhardt Attard, Christopher D Brawley, Simon Chowdhury, William R Cross, David P Dearnaley, Johann S de Bono, Carlos Diaz-Montana, Duncan Gilbert, Silke Gillessen, Clare Gilson, Rob J Jones, Ruth E Langley, Zafar I Malik, David J Matheson, Robin Millman, Chris C Parker, Cheryl Pugh, Hannah Rush, J Martin Russell, Dominik R Berthold, Michelle L Buckner, Malcolm D Mason, Alastair W S Ritchie, Alison J Birtle, Susannah J Brock, Prantik Das, Dan Ford, Joanna Gale, Warren Grant, Emma K Gray, Peter Hoskin, Mohammad M Khan, Caroline Manetta, Neil J McPhail, Joe M O'Sullivan, Omi Parikh, Carla Perna, Carmel J Pezaro, Andrew S Protheroe, Angus J Robinson, Sarah M Rudman, Denise J Sheehan, Narayanan N Srihari, Isabel Syndikus, Jacob S Tanguay, Carys W Thomas, Salil Vengalil, John Wagstaff, James P Wylie, Mahesh K B Parmar, Matthew R Sydes
Abiraterone acetate plus prednisolone (AAP) previously demonstrated improved survival in STAMPEDE, a multiarm, multistage platform trial in men starting long-term hormone therapy for prostate cancer. This long-term analysis in metastatic patients was planned for 3 years after the first results. Standard-of-care (SOC) was androgen deprivation therapy. The comparison randomised patients 1:1 to SOC-alone with or without daily abiraterone acetate 1000 mg + prednisolone 5 mg (SOC + AAP), continued until disease progression...
August 1, 2022: International Journal of Cancer. Journal International du Cancer
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