Frank Bridoux, Nelson Leung, Colin A Hutchison, Guy Touchard, Sanjeev Sethi, Jean-Paul Fermand, Maria M Picken, Guillermo A Herrera, Efstathios Kastritis, Giampaolo Merlini, Murielle Roussel, Fernando C Fervenza, Angela Dispenzieri, Robert A Kyle, Samih H Nasr
Monoclonal gammopathy of renal significance (MGRS) regroups all renal disorders caused by a monoclonal immunoglobulin (MIg) secreted by a nonmalignant B-cell clone. By definition, patients with MGRS do not meet the criteria for overt multiple myeloma/B-cell proliferation, and the hematologic disorder is generally consistent with monoclonal gammopathy of undetermined significance (MGUS). However, MGRS is associated with high morbidity due to the severity of renal and sometimes systemic lesions induced by the MIg...
April 2015: Kidney International