Dora Buonfrate, Joaquin Salas-Coronas, José Muñoz, Begoña Trevino Maruri, Paola Rodari, Francesco Castelli, Lorenzo Zammarchi, Leila Bianchi, Federico Gobbi, Teresa Cabezas-Fernández, Ana Requena-Mendez, Gauri Godbole, Ronaldo Silva, Marilena Romero, Peter L Chiodini, Zeno Bisoffi
BACKGROUND: Strongyloides stercoralis infection is a neglected condition that places people who are immunocompromised at risk of hyperinfection and death. Ivermectin is the drug of choice for the treatment of S stercoralis infection, but there is no definitive evidence on the optimal dose. This trial aimed to assess whether multiple doses of ivermectin were superior to a single dose for the treatment of non-disseminated strongyloidiasis. METHODS: Our study was designed as a multicentre, open-label, phase 3, randomised controlled superiority trial...
November 2019: Lancet Infectious Diseases