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RANDOMIZED CONTROLLED TRIAL
Yasuo Ikeda, Kazuyuki Shimada, Tamio Teramoto, Shinichiro Uchiyama, Tsutomu Yamazaki, Shinichi Oikawa, Masahiro Sugawara, Katsuyuki Ando, Mitsuru Murata, Kenji Yokoyama, Naoki Ishizuka
IMPORTANCE: Prevention of atherosclerotic cardiovascular diseases is an important public health priority in Japan due to an aging population. OBJECTIVE: To determine whether daily, low-dose aspirin reduces the incidence of cardiovascular events in older Japanese patients with multiple atherosclerotic risk factors. DESIGN, SETTING, AND PARTICIPANTS: The Japanese Primary Prevention Project (JPPP) was a multicenter, open-label, randomized, parallel-group trial...
December 17, 2014: JAMA
#2
JOURNAL ARTICLE
Theodore G Ganiats, Jennifer A Kempster
No abstract text is available yet for this article.
July 2014: Journal of the American Board of Family Medicine: JABFM
#3
REVIEW
Aaron J Calderon, James S Newman, Neil H Winawer
No abstract text is available yet for this article.
July 15, 2014: Annals of Internal Medicine
#4
RANDOMIZED CONTROLLED TRIAL
John W Eikelboom, Stuart J Connolly, Martina Brueckmann, Christopher B Granger, Arie P Kappetein, Michael J Mack, Jon Blatchford, Kevin Devenny, Jeffrey Friedman, Kelly Guiver, Ruth Harper, Yasser Khder, Maximilian T Lobmeyer, Hugo Maas, Jens-Uwe Voigt, Maarten L Simoons, Frans Van de Werf
BACKGROUND: Dabigatran is an oral direct thrombin inhibitor that has been shown to be an effective alternative to warfarin in patients with atrial fibrillation. We evaluated the use of dabigatran in patients with mechanical heart valves. METHODS: In this phase 2 dose-validation study, we studied two populations of patients: those who had undergone aortic- or mitral-valve replacement within the past 7 days and those who had undergone such replacement at least 3 months earlier...
September 26, 2013: New England Journal of Medicine
#5
JOURNAL ARTICLE
Emmanuel Stamatakis, Richard Weiler
Despite a large volume of evidence supporting its cardioprotective properties and its other numerous established health benefits, physical activity is not a serious prescription option for the primary prevention of cardiovascular disease. On the other hand, health services increasingly focus on pharmacological prevention without considering properly the long-term consequences of medication. Ethical and feasibility considerations suggest that evidence on the protective value of physical activity may need to be evaluated using criteria different from those applying to pharmacological trials...
February 2010: Heart
#6
COMMENT
Kevin M King, Bruce D Adams
No abstract text is available yet for this article.
June 17, 2014: Annals of Internal Medicine
#7
MULTICENTER STUDY
Marjolein M N Leeuwenburgh, Hein B A C Stockmann, Wim H Bouma, Alexander P J Houdijk, Matthijs F Verhagen, Bart Vrouenraets, Lodewijk P J Cobben, Patrick M M Bossuyt, Jaap Stoker, Marja A Boermeester
OBJECTIVES: The objective was to identify a set of clinical features that can rule out appendicitis in patients with suspected acute appendicitis and nondiagnostic ultrasound (US) results, allowing safe discharge and next-day reevaluation without initial computed tomography (CT) or magnetic resonance imaging (MRI). METHODS: Data on clinical and US evaluation, including a number of prespecified variables potentially associated with acute appendicitis, were prospectively collected in two diagnostic accuracy studies of imaging...
May 2014: Academic Emergency Medicine
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