collection
https://read.qxmd.com/read/26577775/lithium-in-the-kidney-friend-and-foe
#21
REVIEW
Mohammad Alsady, Ruben Baumgarten, Peter M T Deen, Theun de Groot
Trace amounts of lithium are essential for our physical and mental health, and administration of lithium has improved the quality of life of millions of patients with bipolar disorder for >60 years. However, in a substantial number of patients with bipolar disorder, long-term lithium therapy comes at the cost of severe renal side effects, including nephrogenic diabetes insipidus and rarely, ESRD. Although the mechanisms underlying the lithium-induced renal pathologies are becoming clearer, several recent animal studies revealed that short-term administration of lower amounts of lithium prevents different forms of experimental AKI...
June 2016: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/26361800/cell-cycle-arrest-biomarkers-the-light-at-the-end-of-the-acute-kidney-injury-tunnel
#22
COMMENT
Claudio Ronco
No abstract text is available yet for this article.
January 2016: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/25589612/gut-bacteria-products-prevent-aki-induced-by-ischemia-reperfusion
#23
JOURNAL ARTICLE
Vinicius Andrade-Oliveira, Mariane T Amano, Matheus Correa-Costa, Angela Castoldi, Raphael J F Felizardo, Danilo C de Almeida, Enio J Bassi, Pedro M Moraes-Vieira, Meire I Hiyane, Andrea C D Rodas, Jean P S Peron, Cristhiane F Aguiar, Marlene A Reis, Willian R Ribeiro, Claudete J Valduga, Rui Curi, Marco Aurelio Ramirez Vinolo, Caroline M Ferreira, Niels Olsen Saraiva Câmara
Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal microbiota and have anti-inflammatory and histone deacetylase-inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis...
August 2015: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/25359104/unnecessary-renal-replacement-therapy-for-acute-kidney-injury-is-harmful-for-renal-recovery
#24
EDITORIAL
Edward G Clark, Sean M Bagshaw
The use of renal replacement therapy (RRT) for severe acute kidney injury (AKI) is frequently necessary in the face of life-threatening complications; however, there is wide practice variation with respect to triggers for RRT initiation. Recent evidence suggests that RRT may be independently associated with impaired recovery following AKI. There are plausible mechanistic reasons why RRT may be harmful and this concept is supported by ancillary evidence in the form of studies that have assessed the impact of different modalities of RRT for AKI as well as some of the literature pertaining to initiation of chronic hemodialysis in end-stage kidney disease patients (ESKD)...
January 2015: Seminars in Dialysis
https://read.qxmd.com/read/25317932/the-definition-of-acute-kidney-injury-and-its-use-in-practice
#25
REVIEW
Mark E Thomas, Caroline Blaine, Anne Dawnay, Mark A J Devonald, Saoussen Ftouh, Chris Laing, Susan Latchem, Andrew Lewington, David V Milford, Marlies Ostermann
Acute kidney injury (AKI) is a common syndrome that is independently associated with increased mortality. A standardized definition is important to facilitate clinical care and research. The definition of AKI has evolved rapidly since 2004, with the introduction of the Risk, Injury, Failure, Loss, and End-stage renal disease (RIFLE), AKI Network (AKIN), and Kidney Disease Improving Global Outcomes (KDIGO) classifications. RIFLE was modified for pediatric use (pRIFLE). They were developed using both evidence and consensus...
January 2015: Kidney International
https://read.qxmd.com/read/25168507/hemodiafiltration-and-reduction-of-inflammation-in-dialysis-patients
#26
LETTER
Lorenzo A Calò
No abstract text is available yet for this article.
September 2014: Kidney International
https://read.qxmd.com/read/25229340/the-growth-of-acute-kidney-injury-a-rising-tide-or-just-closer-attention-to-detail
#27
JOURNAL ARTICLE
Edward D Siew, Andrew Davenport
Acute kidney injury (AKI), previously termed acute renal failure, is associated with increased mortality, prolonged hospital stay, and accelerated chronic kidney disease (CKD). Over the past 2 decades, dramatic rises in the incidences of AKI have been reported, particularly within the United States. The question arises as to whether these changes reflect actual increases in disease incidence, or are potentially explained by the introduction of consensus definitions that rely on small standardized changes in serum creatinine, changes in coding and reimbursement, or increasingly available and more liberal use of dialysis...
January 2015: Kidney International
https://read.qxmd.com/read/25213433/acid-base-disturbances-in-intensive-care-patients-etiology-pathophysiology-and-treatment
#28
REVIEW
Mohammed Al-Jaghbeer, John A Kellum
Acid-base disturbances are very common in critically ill and injured patients as well as contribute significantly to morbidity and mortality. An understanding of the pathophysiology of these disorders is vital to their proper management. This review will discuss the etiology, pathophysiology and treatment of acid-base disturbances in intensive care patients--with particular attention to evidence from recent studies examining the effects of fluid resuscitation on acid-base and its consequences.
July 2015: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/25185078/clinical-characteristics-causes-and-outcomes-of-acute-interstitial-nephritis-in-the-elderly
#29
JOURNAL ARTICLE
Angela K Muriithi, Nelson Leung, Anthony M Valeri, Lynn D Cornell, Sanjeev Sethi, Mary E Fidler, Samih H Nasr
Acute interstitial nephritis (AIN) is an important cause of acute kidney injury (AKI), and its prevalence in the elderly may be increasing. It is largely unknown whether AIN in the elderly is similar to that in younger adults; therefore, we investigated the causes and characteristics of AIN in 45 elderly patients (65 years and older) and in 88 younger adults (18-64 years old). Compared with younger patients, the elderly had significantly more drug-induced AIN (87 vs. 64%), proton pump inhibitor-induced AIN (18 vs...
February 2015: Kidney International
https://read.qxmd.com/read/23833316/use-of-peritoneal-dialysis-in-aki-a-systematic-review
#30
REVIEW
Chang Yin Chionh, Sachin S Soni, Fredric O Finkelstein, Claudio Ronco, Dinna N Cruz
BACKGROUND AND OBJECTIVES: The role of peritoneal dialysis in the management of AKI is not well defined, although it remains frequently used, especially in low-resource settings. A systematic review was performed to describe outcomes in AKI treated with peritoneal dialysis and compare peritoneal dialysis with extracorporeal blood purification, such as continuous or intermittent hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: MEDLINE, CINAHL, and Central Register of Controlled Trials were searched in July of 2012...
October 2013: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/21430640/the-severity-of-acute-kidney-injury-predicts-progression-to-chronic-kidney-disease
#31
JOURNAL ARTICLE
Lakhmir S Chawla, Richard L Amdur, Susan Amodeo, Paul L Kimmel, Carlos E Palant
Acute kidney injury (AKI) is associated with progression to advanced chronic kidney disease (CKD). We tested whether patients who survive AKI and are at higher risk for CKD progression can be identified during their hospital admission, thus providing opportunities to intervene. This was assessed in patients in the Department of Veterans Affairs Healthcare System hospitalized with a primary diagnosis indicating AKI (ICD9 codes 584.xx). In the exploratory phase, three multivariate prediction models for progression to stage 4 CKD were developed...
June 2011: Kidney International
https://read.qxmd.com/read/25047428/fluid-resuscitation-in-sepsis-a-systematic-review-and-network-meta-analysis
#32
REVIEW
Bram Rochwerg, Waleed Alhazzani, Anees Sindi, Diane Heels-Ansdell, Lehana Thabane, Alison Fox-Robichaud, Lawrence Mbuagbaw, Wojciech Szczeklik, Fayez Alshamsi, Sultan Altayyar, Wang-Chun Ip, Guowei Li, Michael Wang, Anna Wludarczyk, Qi Zhou, Gordon H Guyatt, Deborah J Cook, Roman Jaeschke, Djillali Annane
BACKGROUND: Fluid resuscitation is the cornerstone of sepsis treatment. However, whether balanced or unbalanced crystalloids or natural or synthetic colloids confer a survival advantage is unclear. PURPOSE: To examine the effect of different resuscitative fluids on mortality in patients with sepsis. DATA SOURCES: MEDLINE, EMBASE, ACP Journal Club, CINAHL, HealthSTAR, the Allied and Complementary Medicine Database, and the Cochrane Central Register of Controlled Trials through March 2014...
September 2, 2014: Annals of Internal Medicine
https://read.qxmd.com/read/24066745/resuscitation-fluids
#33
REVIEW
John A Myburgh, Michael G Mythen
New England Journal of Medicine, Volume 369, Issue 13, Page 1243-1251, September 2013.
September 26, 2013: New England Journal of Medicine
https://read.qxmd.com/read/24953892/bile-acid-nephropathy-in-a-bodybuilder-abusing-an-anabolic-androgenic-steroid
#34
JOURNAL ARTICLE
Randy L Luciano, Ekaterina Castano, Gilbert Moeckel, Mark A Perazella
Bile acid nephropathy, also known as cholemic nephrosis or nephropathy, is an entity that can be seen in patients with severe cholestatic liver disease. It typically is associated with acute kidney injury (AKI) with various forms of hepatic disease. Most often, patients with severe obstructive jaundice develop this lesion, which is thought to occur due to direct bile acid injury to tubular cells, as well as obstructing bile acid casts. Patients with end-stage liver disease also can develop AKI, in which case a more heterogeneous lesion occurs that includes hepatorenal syndrome and acute tubular injury/necrosis...
September 2014: American Journal of Kidney Diseases
https://read.qxmd.com/read/24988558/acute-kidney-injury-and-chronic-kidney-disease-as-interconnected-syndromes
#35
REVIEW
Lakhmir S Chawla, Paul W Eggers, Robert A Star, Paul L Kimmel
No abstract text is available yet for this article.
July 3, 2014: New England Journal of Medicine
https://read.qxmd.com/read/24928698/acute-kidney-injury-associated-with-high-nephrotoxic-medication-exposure-leads-to-chronic-kidney-disease-after-6-months
#36
JOURNAL ARTICLE
Shina Menon, Eric S Kirkendall, Hovi Nguyen, Stuart L Goldstein
OBJECTIVE: To assess the development of chronic kidney disease (CKD) after high nephrotoxic medication exposure-associated acute kidney injury (NTMx-AKI) in hospitalized children. STUDY DESIGN: We performed a retrospective cohort study of children exposed to an aminoglycoside for ≥3 days or ≥3 nephrotoxic medications simultaneously for the development of CKD at 6 months. Follow-up data >6 months after acute kidney injury (AKI) were retrieved from electronic health records...
September 2014: Journal of Pediatrics
https://read.qxmd.com/read/24886787/kidney-function-after-off-pump-or-on-pump-coronary-artery-bypass-graft-surgery-a-randomized-clinical-trial
#37
RANDOMIZED CONTROLLED TRIAL
Amit X Garg, P J Devereaux, Salim Yusuf, Meaghan S Cuerden, Chirag R Parikh, Steven G Coca, Michael Walsh, Richard Novick, Richard J Cook, Anil R Jain, Xiangbin Pan, Nicolas Noiseux, Karel Vik, Noedir A Stolf, Andrew Ritchie, Roberto R Favaloro, Sirish Parvathaneni, Richard P Whitlock, Yongning Ou, Mitzi Lawrence, Andre Lamy
IMPORTANCE: Most acute kidney injury observed in the hospital is defined by sudden mild or moderate increases in the serum creatinine concentration, which may persist for several days. Such acute kidney injury is associated with lower long-term kidney function. However, it has not been demonstrated that an intervention that reduces the risk of such acute kidney injury better preserves long-term kidney function. OBJECTIVES: To characterize the risk of acute kidney injury with an intervention in a randomized clinical trial and to determine if there is a difference between the 2 treatment groups in kidney function 1 year later...
June 4, 2014: JAMA
https://read.qxmd.com/read/24855282/developing-risk-prediction-models-for-kidney-injury-and-assessing-incremental-value-for-novel-biomarkers
#38
REVIEW
Kathleen F Kerr, Allison Meisner, Heather Thiessen-Philbrook, Steven G Coca, Chirag R Parikh
The field of nephrology is actively involved in developing biomarkers and improving models for predicting patients' risks of AKI and CKD and their outcomes. However, some important aspects of evaluating biomarkers and risk models are not widely appreciated, and statistical methods are still evolving. This review describes some of the most important statistical concepts for this area of research and identifies common pitfalls. Particular attention is paid to metrics proposed within the last 5 years for quantifying the incremental predictive value of a new biomarker...
August 7, 2014: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/24744281/acute-kidney-injury-in-latin-america-a-view-on-renal-replacement-therapy-resources
#39
MULTICENTER STUDY
Raúl Lombardi, Guillermo Rosa-Diez, Alejandro Ferreiro, Gustavo Greloni, Luis Yu, Mauricio Younes-Ibrahim, Emmanuel A Burdmann
BACKGROUND: Acute kidney injury (AKI) has increasingly been recognized as an important public health issue due to its rising frequency, its associations with early and late adverse outcomes and its economic burden. METHODS: Given the importance of determining the available resources to address this serious issue, the AKI Committee of SLANH conducted a survey to obtain information about infrastructure, human resources and equipment devoted to the treatment of AKI in Latin America RESULTS: A total of 246 units from 14 countries participated in the survey, the majority of them pertaining to nephrology divisions in teaching hospitals...
July 2014: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/24744280/a-real-time-electronic-alert-to-improve-detection-of-acute-kidney-injury-in-a-large-teaching-hospital
#40
JOURNAL ARTICLE
Christine J Porter, Irene Juurlink, Linda H Bisset, Riaz Bavakunji, Rajnikant L Mehta, Mark A J Devonald
BACKGROUND: Acute kidney injury (AKI) is a common and serious problem in hospitalized patients. Early detection is critical for optimal management but in practice is currently inadequate. To improve outcomes in AKI, development of early detection tools is essential. METHODS: We developed an automated real-time electronic alert system employing algorithms which combined internationally recognized criteria for AKI [Risk, Injury, Failure, Loss, End-stage kidney disease (RIFLE) and Acute Kidney Injury Network (AKIN)]...
October 2014: Nephrology, Dialysis, Transplantation
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