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https://read.qxmd.com/read/32052831/a-randomized-controlled-trial-of-ceftriaxone-and-doxycycline-with-or-without-metronidazole-for-the-treatment-of-acute-pelvic-inflammatory-disease
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RANDOMIZED CONTROLLED TRIAL
Harold C Wiesenfeld, Leslie A Meyn, Toni Darville, Ingrid S Macio, Sharon L Hillier
BACKGROUND: Anaerobic organisms are important pathogens in acute pelvic inflammatory disease (PID). The currently recommended PID regimen of a single dose of ceftriaxone and doxycycline for 14 days has limited anaerobic activity. The need for broader anaerobic coverage is unknown and concerns have been raised about metronidazole tolerability. METHODS: We conducted a randomized, double-blind, placebo-controlled trial comparing ceftriaxone 250 mg intramuscular single dose and doxycycline for 14 days, with or without 14 days of metronidazole in women with acute PID...
April 8, 2021: Clinical Infectious Diseases
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