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Inflammatory Bowel Disease Pregnancy

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16 papers 100 to 500 followers
By Chad Klauser Maternal Fetal Medicine physician in NYC
Aoibhlinn O'Toole, Ogochukwu Nwanne, Tracy Tomlinson
BACKGROUND: Inflammatory bowel disease may place women at greater risk of adverse pregnancy outcomes. AIM: To examine the association between inflammatory bowel disease and adverse pregnancy outcomes: preterm birth, small for gestational age (SGA) birth weight, congenital anomalies, and stillbirth. METHODS: We searched PubMed, EMBASE, the Cochrane Database of Systematic Reviews, and for studies published from January 1980 through February 2014 and reference lists of relevant studies...
September 2015: Digestive Diseases and Sciences
Heather A Boyd, Saima Basit, Maria C Harpsøe, Jan Wohlfahrt, Tine Jess
BACKGROUND AND OBJECTIVES: Existing data on pregnancy complications in inflammatory bowel disease (IBD) are inconsistent. To address these inconsistencies, we investigated potential associations between IBD, IBD-related medication use during pregnancy, and pregnancy loss, pre-eclampsia, preterm delivery, Apgar score, and congenital abnormalities. METHODS: We conducted a cohort study in >85,000 Danish National Birth Cohort women who were pregnant in the period 1996-2002 and had information on IBD, IBD-related medication use (systemic or local corticosteroids, 5-aminosalicylates), pregnancy outcomes and potential confounders...
2015: PloS One
Yukiko Kubota-Sjogren, Kate Harding, Peter Irving, Catherine Nelson-Piercy
No abstract text is available yet for this article.
November 2014: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Nabeel Khan, Hamna Asim, Gary R Lichtenstein
Introduction: The highest incidence of inflammatory bowel disease (IBD) is seen between the second and fourth decades of life, which is the most fertile age for women. Increased disease activity has been shown to effect female fertility and pregnancy outcomes, stressing the need for drugs that can safely induce and maintain clinical remission without harming either the mother or fetus. Areas covered: Anti-TNF-α agents have been shown to be effective in both inducing and maintaining remission among IBD patients...
October 30, 2014: Expert Opinion on Drug Safety
S Mozaffari, A H Abdolghaffari, S Nikfar, M Abdollahi
Several studies have indicated the harmful effect of flare-up periods in pregnant women with inflammatory bowel disease (IBD) on their newborns. Therefore, an effective and safe medical treatment during pregnancy is of great concern in IBD patients. The aim of this study was to perform a meta-analysis on the outcomes of thiopurines use and a systematic review of antitumor necrosis factor (anti-TNF) drugs used during pregnancy in women with IBD. The results of cohorts evaluating the safety of anti-TNF drugs during pregnancy up to July 2013 were collected and analyzed...
May 2015: Human & Experimental Toxicology
Ashwin N Ananthakrishnan, Alice Cheng, Andrew Cagan, Tianxi Cai, Vivian S Gainer, Stanley Y Shaw, Susanne Churchill, Elizabeth W Karlson, Shawn N Murphy, Isaac Kohane, Katherine P Liao
INTRODUCTION: Inflammatory bowel diseases [IBD; Crohn's disease (CD), ulcerative colitis] often affect women in their reproductive years. Few studies have analyzed the impact of mode of childbirth on long-term IBD outcomes. METHODS: We used a multi-institutional IBD cohort to identify all women in the reproductive age-group with a diagnosis of IBD prior to pregnancy. We identified the occurrence of a new diagnosis code for perianal complications, IBD-related hospitalization and surgery, and initiation of medical therapy after either a vaginal delivery or caesarean section (CS)...
February 2015: Digestive Diseases and Sciences
H Schulze, P Esters, A Dignass
BACKGROUND: Inflammatory bowel diseases (IBD) commonly affect young patients in the reproductive phase of their lives. The chronic and relapsing nature of IBD and the potential need for medical or surgical interventions raise concerns about family planning issues. AIM: To review the current knowledge on IBD management in pregnant and nursing IBD patients. METHODS: A PubMed literature search was performed using the search terms 'reproduction' and 'inflammatory bowel disease' and using the headers and main subjects of each section of this article as search terms...
November 2014: Alimentary Pharmacology & Therapeutics
Didia Bismara Cury, Alan C Moss
Inflammatory bowel disease affects a substantial number of women in their reproductive years. Pregnancy presents a number of challenges for clinicians and patients; the health of the baby needs to be balanced with the need to maintain remission in the mother. Historically, treatments for Crohn's disease (CD) were often discontinued during the pregnancy, or nursing period, due to concerns about teratogenicity. Fortunately, observational data has reported the relative safety of many agents used to treat CD, including 5-aminosalicylic acid, thiopurines, and tumor necrosis factor...
July 21, 2014: World Journal of Gastroenterology: WJG
Y Kubota-Sjogren
BACKGROUND: Inflammatory Bowel Disease (IBD) are chronic conditions commonly presenting in the reproductive years with up to 620000 people affected in the UK. Numerous specialist studies and reviews looking at IBD and fertility, IBD medications during pregnancy and breastfeeding, pregnancy outcome in IBD patients exist, but there is no summarising review for clinicians or patients, thus women may not receive consistent advice. OBJECTIVE: Design and present a management algorithm for clinicians and information leaflet for women with IBD consistent with current literature and available guidelines...
June 2014: Archives of Disease in Childhood. Fetal and Neonatal Edition
D Getahun, M J Fassett, G F Longstreth, C Koebnick, A M Langer-Gould, D Strickland, S J Jacobsen
OBJECTIVE: To examine whether inflammatory bowel disease (IBD) is associated with ischemic/inflammatory conditions during pregnancy. STUDY DESIGN: A retrospective cohort study using the 2000 to 2012 Kaiser Permanente Southern California maternally-linked medical records (n=395 781). The two major subtypes of IBD, ulcerative colitis and Crohn's diseases were studied. Adjusted odds ratios (ORs) were used to quantify the associations. RESULT: A pregnancy complicated by IBD was associated with increased incidence of small-for-gestational age birth (OR=1...
June 2014: Journal of Perinatology: Official Journal of the California Perinatal Association
Arul Thomas, Nilesh Lodhia
Primary care physicians care for patients with inflammatory bowel disease (IBD) who are receiving advanced therapies that include immunomodulator drugs (eg, azathioprine and methotrexate) and biologic therapy. These agents have significantly improved remission rates and the quality of life for patients suffering from IBD. However, patients taking these drugs need special care and counseling with regard to adverse effects, infection risk, cancer risk, and pregnancy. Newer treatment paradigms incorporate earlier use of biologic therapy, often in combination with immunomodulator drugs, to alter the natural course of the disease...
May 2014: Journal of the American Board of Family Medicine: JABFM
Stefano Palomba, Giuliana Sereni, Angela Falbo, Marina Beltrami, Silvia Lombardini, Maria Chiara Boni, Giovanni Fornaciari, Romano Sassatelli, Giovanni Battista La Sala
To evaluate the effects of inflammatory bowel diseases (IBDs) on human reproduction, we reviewed the current literature using a systematic search for published studies (articles and/or abstracts) without limits for English language. We searched on Medline (through PubMed), the Institute for Scientific Information, the Web of Science and the websites for the registration of controlled trials ( Bibliographies of retrieved articles, books, expert opinion review articles and reviewed bibliographies from subject experts were manually searched...
June 21, 2014: World Journal of Gastroenterology: WJG
Neeraj Narula, Raed Al-Dabbagh, Amit Dhillon, Bruce E Sands, John K Marshall
BACKGROUND: The use of TNFα antagonists is well described for inflammatory bowel disease (IBD), but their safety profile during pregnancy is yet to be fully elucidated. A systematic review and meta-analysis were performed to identify studies that explored the safety of anti-TNFα therapy during pregnancy in patients with IBD. METHODS: A systematic literature search was conducted to identify studies that investigated the pregnancy outcomes among women with IBD on anti-TNFα therapy...
October 2014: Inflammatory Bowel Diseases
Quinton Hatch, Bradley J Champagne, Justin A Maykel, Bradley R Davis, Eric K Johnson, Joshua I Bleier, Todd D Francone, Scott R Steele
BACKGROUND: The impact of pregnancy on the course of Crohn disease is largely unknown. Retrospective surveys have suggested a variable effect, but there are limited population-based clinical data. We hypothesized pregnant women with Crohn disease will have similar rates of surgical disease as a nonpregnant Crohn disease cohort. MATERIAL AND METHODS: International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify female Crohn patients from all patients admitted using the Nationwide Inpatient Sample (1998-2009)...
July 2014: Journal of Surgical Research
C Seifarth, J P Ritz, U Pohlen, A J Kroesen, B Siegmund, B Frericks, H J Buhr
BACKGROUND: Severe courses of Crohn's disease (CD) during pregnancy are rare. However, if occurring, the risk of miscarriage and low birth weight is increased. At present, only limited data is available on the treatment of CD during pregnancy. In particular, there are no standard guidelines for surgical therapy. Nevertheless, surgery is often unavoidable if complications during the course of the disease arise. PURPOSE: This study provides a critical overview of conventional and interventional treatment options for CD complications during pregnancy and analyses the surgical experience gained thus far...
June 2014: International Journal of Colorectal Disease
Gabriella Bröms, Fredrik Granath, Marie Linder, Olof Stephansson, Maria Elmberg, Helle Kieler
BACKGROUND: Ulcerative colitis (UC) and Crohn's disease (CD) have been associated with increased risks of adverse birth outcomes. Disease activity and drug exposure may contribute to the association. METHODS: A cohort from the Swedish health registers including 470,110 singleton births in Sweden from July 2006 to December 2010; 1833 to women with UC and 1220 to women with CD. Birth outcomes for women with UC and CD were compared with outcomes among those without disease...
June 2014: Inflammatory Bowel Diseases
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